Research Group Fabritz


Name:
Prof. Dr. Larissa Fabritz
Department/Center/Institute: University Heart and Vascular Center Hamburg (UHZ),
University Center of Cardiovascular Science (UCCS)
Email: l.fabritz@uke.de
Phone: +49 (0) 40 7410 - 57980

Professor Fabritz and colleagues at UHZ also see patients with inheritable cardiac conditions like channelopathies and arrhythmogenic cardiomyopathies (e.g. ARVC) in the inherited cardiac conditions clinic of UHZ.

Please contact herz-gefaessambulanz@uke.de /call +49 (0) 40 7410 - 52961 for an appointment in ICC clinic.

Research Focus and Main research questions

Translational Research in Inherited Cardiac Conditions with a Focus on Arrhythmias and Cardiomyopathies.

Research Projects

  • Molecular mechanisms of atrial fibrillation and atrial thrombosis
  • Sodium channel dysfunction and its role in atrial and ventricular arrhythmias
  • Desmosomal proteins
  • Effects of ageing and exercise on arrhythmia and cardiomyopathy
  • Translation of preclinical research into clinical trials
  • Circulating biomolecules to guide diagnosis and therapy of cardiomyopathies and arrhythmias
  • Statistical modelling, big data and machine learning techniques for cardiovascular research
  • Mobile and wearable tools for atrial fibrillation screening, therapy adherence and patient engagement and improvement of personalised prevention and management of care in patients with atrial fibrillation

  • Methods
  • Methods

    Methods:

    • Translation of preclinical research into clinical trials
    • Screening for atrial fibrillation including wearables
    • Development of mobile apps for adherent therapy and patient engagement
    • Identification and characterization of biomarkers for cardiomyopathy and arrhythmia
    • Big data and machine learning techniques for cardiovascular data
    • Experimental echocardiography and ECG
    • Experimental electrophysiology including optical mapping
    • Molecular and cell biology (qPCR, Western Blot, ELISA)
    • Histology, immunohistochemistry, immunofluorescence microscopy
    • Atrial and ventricular cardiomyocyte isolation
    • Measurement and analysis of intracellular calcium dynamics

  • Recent Funding:

    2022-2024 NIHR Award “a pilot study to assess the safety, effectiveness and practical utility of remote patient monitoring to guide the timing of valve intervention in patients with asymptomatic severe aortic stenosis” (APRAISE-AS)
    2021-2026 EU Horizon - MAESTRIA: Machine Learning Artificial Intelligence Early Detection Stoke Atrial Fibrillation
    2020-2024 EU Horizon 2020 - Digital, risk-based screening for atrial fibrillation in the european community (AFFECT-EU)
    2020-2021 SMART in OAC
    2019-2024 BHF research Excellence Accelerator
    2019-2022 Project grant BHF, to Brand UCL
    2019-2024 Center for Doctoral Training (CDT) in topological design
    2017-2020 FS/17/7/32651 Brain, Fabritz, Marshall. Non-clinical Studentship. Developing new, fluorescence-based techniques to study sympathetic nerve function within blood vessels and the heart
    2015-2019 European Union Horizon. Characterizing atrial fibrillation by translating its causes into health modifiers in the ealderly (CATCH ME)
    2013-2018 BHF. Understanding the function of Pitx2 in the adult left atrium

Publications

For the full list of publications, please visit PubMed and/or "Forschungsportal" (see link below)

Zurück
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
Vor

Improving antiarrhythmic therapy for patients with atrial fibrillation using common genetic variants
Lemoine M, Fabritz L
HEART. 2025;111(4):145-146.

Comparison of cardiac troponin assays reveals assay-specific sensitivities in a clinical model of very acute myocardial injury
Obergassel J, Lemoine M, Sommerfeld L, Rieß J, Al-Aqili S, Jäckle S, Rottner L, Rillig A, Metzner A, Sörensen N, Fabritz L, Renné T, Twerenbold R, Blankenberg S, Zeller T, Kirchhof P, Neumann J
EUR HEART J-ACUTE CA. 2025 [Epub ahead of print].

Short-term benefit of early rhythm control for atrial fibrillation: the EAST-AFNET 4 trial
Obergassel J, Suling A, Borof K, Camm A, Crijns H, Eckardt L, Fabritz L, Goette A, Jensen M, Lemoine M, Magnussen C, Metzner A, Rillig A, Schotten U, Schnabel R, Thomalla G, Vardas P, Wakili R, Willems S, Zapf A, Kirchhof P, Schrage B
EUR HEART J. 2025 [Epub ahead of print].

Structural Progression in Patients with Definite and Non-Definite Arrhythmogenic Right Ventricular Cardiomyopathy and Risk of Major Adverse Cardiac Events
Aljehani A, Baig S, Kew T, Kalla M, Sommerfeld L, Murukutla V, Fabritz L, Steeds R
BIOMEDICINES. 2024;12(2):.

Prognostic Value of Strain by Speckle Tracking Echocardiography in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy
Aljehani A, Win K, Baig S, Kalla M, Ensam B, Fabritz L, Steeds R
J CARDIOVASC DEV DIS. 2024;11(12):.

Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study
Chua W, Khashaba A, Canagarajah H, Nielsen J, di Biase L, Haeusler K, Hindricks G, Mont L, Piccini J, Schnabel R, Schotten U, Wienhues-Thelen U, Zeller T, Fabritz L, Kirchhof P
EUROPACE. 2024;26(2):.

Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study
Fabritz L, Al-Taie C, Borof K, Breithardt G, Camm A, Crijns H, Roth Cardoso V, Chua W, van Elferen S, Eckardt L, Gkoutos G, Goette A, Guasch E, Hatem S, Metzner A, Mont L, Murukutla V, Obergassel J, Rillig A, Sinner M, Schnabel R, Schotten U, Sommerfeld L, Wienhues-Thelen U, Zapf A, Zeller T, Kirchhof P
EUR HEART J. 2024;45(47):5002-5019.

Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study
Fabritz L, Chua W, Cardoso V, Al-Taie C, Borof K, Suling A, Krause L, Kany S, Magnussen C, Wegscheider K, Breithardt G, Crijns H, Camm A, Gkoutos G, Ellinor P, Goette A, Schotten U, Wienhues-Thelen U, Zeller T, Schnabel R, Zapf A, Kirchhof P
CARDIOVASC RES. 2024;120(8):855-868.

Endurance Training Provokes Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Heterozygous Desmoglein-2 Mutants: Alleviation by Preload Reduction
Fabritz L, Fortmueller L, Gehmlich K, Kant S, Kemper M, Kucerova D, Syeda F, Faber C, Leube R, Kirchhof P, Krusche C
BIOMEDICINES. 2024;12(5):.

Atrial fibrillation in the young: consider heritable conditions like short QT syndrome
Fabritz L, Lemoine M
CARDIOVASC RES. 2024;120(5):437-439.

Multimodal characterization of dilated cardiomyopathy: Geno- And Phenotyping of PrImary Cardiomyopathy (GrAPHIC)
Keil L, Berisha F, Ritter S, Skibowski J, Subramanian H, Nikolaev V, Kubisch C, Woitschach R, Fabritz L, Twerenbold R, Blankenberg S, Weidemann S, Zeller T, Kirchhof P, Reichart D, Magnussen C
ESC HEART FAIL. 2024;11(1):541-549.

Pilot study to evaluate the use of remote patient monitoring to guide the timing of valve intervention in patients with severe asymptomatic aortic stenosis (APRAISE-AS): study protocol for a randomised controlled trial delivered in two tertiary cardiac centres in the UK
Khan N, Steeds R, Kyte D, Fabritz L, Collis P, Chua W, Stubbs C, Mehta S, Sun Y, Nulty M, Kirkham K, Cotton J
BMJ OPEN. 2024;14(6):e086587.

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Linz D, Andrade J, Arbelo E, Boriani G, Breithardt G, Camm A, Caso V, Nielsen J, De Melis M, De Potter T, Dichtl W, Diederichsen S, Dobrev D, Doll N, Duncker D, Dworatzek E, Eckardt L, Eisert C, Fabritz L, Farkowski M, Filgueiras-Rama D, Goette A, Guasch E, Hack G, Hatem S, Haeusler K, Healey J, Heidbuechel H, Hijazi Z, Hofmeister L, Hove-Madsen L, Huebner T, Kääb S, Kotecha D, Malaczynska-Rajpold K, Merino J, Metzner A, Mont L, Ng G, Oeff M, Parwani A, Puererfellner H, Ravens U, Rienstra M, Sanders P, Scherr D, Schnabel R, Schotten U, Sohns C, Steinbeck G, Steven D, Toennis T, Tzeis S, van Gelder I, van Leerdam R, Vernooy K, Wadhwa M, Wakili R, Willems S, Witt H, Zeemering S, Kirchhof P
EUROPACE. 2024;26(4):.

Overexpression of VEGFα as a biomarker of endothelial dysfunction in aortic tissue of α-GAL-Tg/KO mice and its upregulation in the serum of patients with Fabry’s disease
Lund N, Wieboldt H, Fischer L, Muschol N, Braun F, Huber T, Sorriento D, Iaccarino G, Muellerleile K, Tahir E, Adam G, Kirchhof P, Fabritz L, Patten M
FRONT CARDIOVASC MED. 2024;11(11):1355033.

Publisher Correction: High resolution optical mapping of cardiac electrophysiology in pre-clinical models
O'Shea C, Winter J, Kabir S, O'Reilly M, Wells S, Baines O, Sommerfeld L, Correia J, Lei M, Kirchhof P, Holmes A, Fabritz L, Rajpoot K, Pavlovic D
SCI DATA. 2024;11(1):93.

PITX2 deficiency leads to atrial mitochondrial dysfunction
Reyat J, Sommerfeld L, O'Reilly M, Roth Cardoso V, Thiemann E, Khan A, O'Shea C, Harder S, Müller C, Barlow J, Stapley R, Chua W, Kabir S, Grech O, Hummel O, Hübner N, Kääb S, Mont L, Hatem S, Winters J, Zeemering S, Morgan N, Rayes J, Gehmlich K, Stoll M, Brand T, Schweizer M, Piasecki A, Schotten U, Gkoutos G, Lorenz K, Cuello F, Kirchhof P, Fabritz L
CARDIOVASC RES. 2024;120(15):1907-1923.

Safety and efficacy of long-term Sodium Channel Blocker therapy for Early Rhythm Control: The EAST-AFNET 4 trial
Rillig A, Eckardt L, Borof K, Camm A, Crijns H, Goette A, Breithardt G, Lemoine M, Metzner A, Rottner L, Schotten U, Vettorazzi E, Wegscheider K, Zapf A, Heidbuchel H, Willems S, Fabritz L, Schnabel R, Magnussen C, Kirchhof P
EUROPACE. 2024;26(6):.

Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5
Rinné S, Kiper A, Jacob R, Ortiz-Bonnin B, Schindler R, Fischer S, Komadowski M, deMartino E, Schäfer M, Cornelius T, Fabritz L, Helker C, Brand T, Decher N
ISCIENCE. 2024;27(5):109696.

Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse
Sommerfeld L, Holmes A, Yu T, O'Shea C, Kavanagh D, Pike J, Wright T, Syeda F, Aljehani A, Kew T, Cardoso V, Kabir S, Hepburn C, Menon P, Broadway-Stringer S, O'Reilly M, Witten A, Fortmueller L, Lutz S, Kulle A, Gkoutos G, Pavlovic D, Arlt W, Lavery G, Steeds R, Gehmlich K, Stoll M, Kirchhof P, Fabritz L
J PHYSIOL-LONDON. 2024;602(18):4409-4436.

Characterisation of patients referred to a tertiary-level inherited cardiac condition clinic with suspected arrhythmogenic right ventricular cardiomyopathy (ARVC).
Aljehani A, Kew T, Baig S, Cox H, Sommerfeld L, Ensam B, Kalla M, Steeds R, Fabritz L
BMC CARDIOVASC DISOR. 2023;23(1):14.

An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions
Chua W, Cardoso V, Guasch E, Sinner M, Al-Taie C, Brady P, Casadei B, Crijns H, Dudink E, Hatem S, Kääb S, Kastner P, Mont L, Nehaj F, Purmah Y, Reyat J, Schotten U, Sommerfeld L, Zeemering S, Ziegler A, Gkoutos G, Kirchhof P, Fabritz L
SCI REP-UK. 2023;13(1):16743.

Early rhythm-control therapy for atrial fibrillation in patients with a history of stroke: a subgroup analysis of the EAST-AFNET 4 trial
Jensen M, Suling A, Metzner A, Schnabel R, Borof K, Goette A, Haeusler K, Zapf A, Wegscheider K, Fabritz L, Diener H, Thomalla G, Kirchhof P
LANCET NEUROL. 2023;22(1):45-54.

Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial
Kany S, Al-Taie C, Roselli C, Pirruccello J, Borof K, Reinbold C, Suling A, Krause L, Reissmann B, Schnabel R, Zeller T, Zapf A, Wegscheider K, Fabritz L, Ellinor P, Kirchhof P
CARDIOVASC RES. 2023;119(9):1799-1810.

Pulmonary Vein Isolation by Pulsed-field Ablation Induces Less Neurocardiac Damage Than Cryoballoon Ablation
Lemoine M, Mencke C, Nies M, Obergassel J, Scherschel K, Wieboldt H, Schleberger R, My I, Rottner L, Moser J, Kany S, Wenzel J, Moser F, Dinshaw L, Münkler P, Reissmann B, Ouyang F, Meyer C, Blankenberg S, Zeller T, Fabritz L, Rillig A, Metzner A, Kirchhof P
CIRC-ARRHYTHMIA ELEC. 2023;16(4):e011598.

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide
O’Reilly M, Sommerfeld L, O’Shea C, Broadway-Stringer S, Andaleeb S, Reyat J, Kabir S, Stastny D, Malinova A, Delbue D, Fortmueller L, Gehmlich K, Pavlovic D, Skryabin B, Holmes A, Kirchhof P, Fabritz L
EUROPACE. 2023;25(3):1152-1161.

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference
Schnabel R, Marinelli E, Arbelo E, Boriani G, Boveda S, Buckley C, Camm A, Casadei B, Chua W, Dagres N, de Melis M, Desteghe L, Diederichsen S, Duncker D, Eckardt L, Eisert C, Engler D, Fabritz L, Freedman B, Gillet L, Goette A, Guasch E, Svendsen J, Hatem S, Haeusler K, Healey J, Heidbuchel H, Hindricks G, Hobbs F, Hübner T, Kotecha D, Krekler M, Leclercq C, Lewalter T, Lin H, Linz D, Lip G, Løchen M, Lucassen W, Malaczynska-Rajpold K, Massberg S, Merino J, Meyer R, Mont L, Myers M, Neubeck L, Niiranen T, Oeff M, Oldgren J, Potpara T, Psaroudakis G, Pürerfellner H, Ravens U, Rienstra M, Rivard L, Scherr D, Schotten U, Shah D, Sinner M, Smolnik R, Steinbeck G, Steven D, Svennberg E, Thomas D, True Hills M, van Gelder I, Vardar B, Palà E, Wakili R, Wegscheider K, Wieloch M, Willems S, Witt H, Ziegler A, Daniel Zink M, Kirchhof P
EUROPACE. 2023;25(1):6-27.

Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium
Winters J, Isaacs A, Zeemering S, Kawczynski M, Maesen B, Maessen J, Bidar E, Boukens B, Hermans B, van Hunnik A, Casadei B, Fabritz L, Chua W, Sommerfeld L, Guasch E, Mont L, Batlle M, Hatem S, Kirchhof P, Wakili R, Sinner M, Stoll M, Goette A, Verheule S, Schotten U
J AM HEART ASSOC. 2023;12(22):e031220.

Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death
Brady P, Chua W, Nehaj F, Connolly D, Khashaba A, Purmah Y, Ul-Qamar M, Thomas M, Varma C, Schnabel R, Zeller T, Fabritz L, Kirchhof P
J AM HEART ASSOC. 2022;11(4):.

Smartphone and wearable detected atrial arrhythmias in Older Adults: Results of a fully digital European Case finding study
Fabritz L, Connolly D, Czarnecki E, Dudek D, Guasch E, Haase D, Huebner T, Zlahoda-Huzior A, Jolly K, Kirchhof P, Obergassel J, Schotten U, Vettorazzi E, Winkelmann S, Zapf A, Schnabel R
European heart journal. Digital health. 2022;3(4):610-625.

Remote Design of a Smartphone and Wearable Detected Atrial Arrhythmia in Older Adults Case Finding Study: Smart in OAC - AFNET 9
Fabritz L, Connolly D, Czarnecki E, Dudek D, Zlahoda-Huzior A, Guasch E, Haase D, Huebner T, Jolly K, Kirchhof P, Schotten U, Zapf A, Schnabel R
FRONT CARDIOVASC MED. 2022;9:.

Artificial intelligence for early atrial fibrillation detection
Fabritz L, Obergassel J
LANCET. 2022;400(10359):1173-1175.

Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank
Kany S, Cardoso V, Bravo L, Williams J, Schnabel R, Fabritz L, Gkoutos G, Kirchhof P
HEART. 2022;108(23):1873-1880.

LMNA Mutation in a Family with a Strong History of Sudden Cardiac Death
Keil L, Berisha F, Knappe D, Kubisch C, Shoukier M, Kirchhof P, Fabritz L, Hellenbroich Y, Woitschach R, Magnussen C
GENES-BASEL. 2022;13(2):.

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
Kotanidis C, Xie C, Alexander D, Rodrigues J, Burnham K, Mentzer A, O'Connor D, Knight J, Siddique M, Lockstone H, Thomas S, Kotronias R, Oikonomou E, Badi I, Lyasheva M, Shirodaria C, Lumley S, Constantinides B, Sanderson N, Rodger G, Chau K, Lodge A, Tsakok M, Gleeson F, Adlam D, Rao P, Indrajeet D, Deshpande A, Bajaj A, Hudson B, Srivastava V, Farid S, Krasopoulos G, Sayeed R, Ho L, Neubauer S, Newby D, Channon K, Deanfield J, Antoniades C
LANCET DIGIT HEALTH. 2022;4(10):e705-e716.

Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels
O' Brien S, Holmes A, Johnson D, Kabir S, O' Shea C, O' Reilly M, Avezzu A, Reyat J, Hall A, Apicella C, Ellinor P, Niederer S, Tucker N, Fabritz L, Kirchhof P, Pavlovic D
J MOL CELL CARDIOL. 2022;166:23-35.

High resolution optical mapping of cardiac electrophysiology in pre-clinical models
O'Shea C, Winter J, Kabir S, O'Reilly M, Wells S, Baines O, Sommerfeld L, Correia J, Lei M, Kirchhof P, Holmes A, Fabritz L, Rajpoot K, Pavlovic D
SCI DATA. 2022;9(1):.

Trends in the pharmacological management of atrial fibrillation in UK general practice 2008-2018
Phillips K, Subramanian A, Thomas G, Khan N, Chandan J, Brady P, Marshall T, Nirantharakumar K, Fabritz L, Adderley N
HEART. 2022;108(7):517-522.

Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Ripplinger C, Glukhov A, Kay M, Boukens B, Chiamvimonvat N, Delisle B, Fabritz L, Hund T, Knollmann B, Li N, Murray K, Poelzing S, Quinn T, Remme C, Rentschler S, Rose R, Posnack N
AM J PHYSIOL-HEART C. 2022;323(6):H1137-H1166.

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart
van der Velden J, Asselbergs F, Bakkers J, Batkai S, Bertrand L, Bezzina C, Bot I, Brundel B, Carrier L, Chamuleau S, Ciccarelli M, Dawson D, Davidson S, Dendorfer A, Duncker D, Eschenhagen T, Fabritz L, Falcão-Pires I, Ferdinandy P, Giacca M, Girao H, Gollmann-Tepeköylü C, Gyongyosi M, Guzik T, Hamdani N, Heymans S, Hilfiker A, Hilfiker-Kleiner D, Hoekstra A, Hulot J, Kuster D, van Laake L, Lecour S, Leiner T, Linke W, Lumens J, Lutgens E, Madonna R, Maegdefessel L, Mayr M, van der Meer P, Passier R, Perbellini F, Perrino C, Pesce M, Priori S, Remme C, Rosenhahn B, Schotten U, Schulz R, Sipido K, Sluijter J, van Steenbeek F, Steffens S, Terracciano C, Tocchetti C, Vlasman P, Yeung K, Zacchigna S, Zwaagman D, Thum T
CARDIOVASC RES. 2022;118(15):3016-3051.

Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis, inflammation, and endothelial dysfunction
Zeemering S, Isaacs A, Winters J, Maesen B, Bidar E, Dimopoulou C, Guasch E, Batlle M, Haase D, Hatem S, Kara M, Kääb S, Mont L, Sinner M, Wakili R, Maessen J, Crijns H, Fabritz L, Kirchhof P, Stoll M, Schotten U
HEART RHYTHM. 2022;19(12):2115-2124.

Mobile Apps to Improve Medication Adherence in Cardiovascular Disease: Systematic Review and Meta-analysis
Al-Arkee S, Mason J, Lane D, Fabritz L, Chua W, Haque M, Jalal Z
J MED INTERNET RES. 2021;23(5):.

Resting cardiac sympathetic firing frequencies suppress terminal norepinephrine transporter uptake
Cao L, Marshall J, Fabritz L, Brain K
AUTON NEUROSCI-BASIC. 2021;232:.

Heart failure in patients with atrial fibrillation: why it matters now more than ever
Chua W, Fabritz L
HEART. 2021;107(16):1278-1279.

Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study
Chua W, Law J, Cardoso V, Purmah Y, Neculau G, Jawad-Ul-Qamar M, Russell K, Turner A, Tull S, Nehaj F, Brady P, Kastner P, Ziegler A, Gkoutos G, Pavlovic D, Ferro C, Kirchhof P, Fabritz L
PLOS MED. 2021;18(2):.

Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference
Fabritz L, Crijns H, Guasch E, Goette A, Häusler K, Kotecha D, Lewalter T, Meyer C, Potpara T, Rienstra M, Schnabel R, Willems S, Breithardt G, Camm A, Chan A, Chua W, de Melis M, Dimopoulou C, Dobrev D, Easter C, Eckardt L, Haase D, Hatem S, Healey J, Heijman J, Hohnloser S, Huebner T, Ilyas B, Isaacs A, Kutschka I, Leclercq C, Lip G, Marinelli E, Merino J, Mont L, Nabauer M, Oldgren J, Pürerfellner H, Ravens U, Savelieva I, Sinner M, Sitch A, Smolnik R, Steffel J, Stein K, Stoll M, Svennberg E, Thomas D, Van Gelder I, Vardar B, Wakili R, Wieloch M, Zeemering S, Ziegler P, Heidbuchel H, Hindricks G, Schotten U, Kirchhof P
EUROPACE. 2021;23(3):329-344.

Taking the heavy load off arrhythmogenic right ventricular cardiomyopathy
Fabritz L, Patten M, Kirchhof P
HEART RHYTHM. 2021;18(7):1192-1193.

Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone
Holmes A, Saxena P, Kabir S, O'Shea C, Kuhlmann S, Gupta S, Fobian D, Apicella C, O'Reilly M, Syeda F, Reyat J, Smith G, Workman A, Pavlovic D, Fabritz L, Kirchhof P
HEART RHYTHM. 2021;18(7):1212-1220.

Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation
Künzel S, Hoffmann M, Weber S, Künzel K, Kämmerer S, Günscht M, Klapproth E, Rausch J, Sadek M, Kolanowski T, Meyer-Roxlau S, Piorkowski C, Tugtekin S, Rose-John S, Yin X, Mayr M, Kuhlmann J, Wimberger P, Grützmann K, Herzog N, Küpper J, O'Reilly M, Kabir S, Sommerfeld L, Guan K, Wielockx B, Fabritz L, Nattel S, Ravens U, Dobrev D, Wagner M, El-Armouche A
CIRC RES. 2021;129(8):804-820.

Effects of genetic background, sex, and age on murine atrial electrophysiology
Obergassel J, O'Reilly M, Sommerfeld L, Kabir S, O'Shea C, Syeda F, Eckardt L, Kirchhof P, Fabritz L
EUROPACE. 2021;23(6):958-969.

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research
Odening K, Gomez A, Dobrev D, Fabritz L, Heinzel F, Mangoni M, Molina C, Sacconi L, Smith G, Stengl M, Thomas D, Zaza A, Remme C, Heijman J
EUROPACE. 2021;23(11):1795-1814.

Coronary microvascular dysfunction is associated with degree of anaemia in end-stage renal disease
Radhakrishnan A, Pickup L, Price A, Law J, McGee K, Fabritz L, Senior R, Steeds R, Ferro C, Townend J
BMC CARDIOVASC DISOR. 2021;21(1):.

Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control
Rathjens F, Blenkle A, Iyer L, Renger A, Syeda F, Noack C, Jungmann A, Dewenter M, Toischer K, El-Armouche A, Müller O, Fabritz L, Zimmermann W, Zelarayan L, Zafeiriou M
CARDIOVASC RES. 2021;117(8):1908-1922.

Mobile health for walking on the tightrope of optimal physical activity to reduce the risk of atrial fibrillation
Schnabel R, Fabritz L, Kirchhof P
EUR HEART J. 2021;42(25):2484-2486.

Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release
Simon J, Vrellaku B, Monterisi S, Chu S, Rawlings N, Lomas O, Marchal G, Waithe D, Syeda F, Gajendragadkar P, Jayaram R, Sayeed R, Channon K, Fabritz L, Swietach P, Zaccolo M, Eaton P, Casadei B
CIRCULATION. 2021;143(5):449-465.

Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA-R)
Sinning C, Zengin E, Diller G, Onorati F, Castel M, Petit T, Chen Y, Lo Rito M, Chiarello C, Guillemain R, Coniat K, Magnussen C, Knappe D, Becher P, Schrage B, Smits J, Metzner A, Knosalla C, Schoenrath F, Miera O, Cho M, Weimann J, Goßling A, Terzi A, Amodeo A, Alfieri S, Angeli E, Ragni L, Napoleone C, Gerosa G, Pradegan N, Rodrigus I, Dumfarth J, de Pauw M, François K, Van Caenegem O, Ancion A, Van Cleemput J, Miličić D, Moza A, Schenker P, Thul J, Steinmetz M, Warnecke G, Ius F, Freyt S, Avsar M, Sandhaus T, Haneya A, Eifert S, Saeed D, Borger M, Welp H, Ablonczy L, Schmack B, Ruhparwar A, Naito S, Hua X, Fluschnik N, Nies M, Keil L, Senftinger J, Ismaili D, Kany S, Csengeri D, Cardillo M, Oliveti A, Faggian G, Dorent R, Jasseron C, Blanco A, Márquez J, López-Vilella R, García-Álvarez A, López M, Rocafort A, Fernández Ó, Prieto-Arevalo R, Zatarain-Nicolás E, Blanchart K, Boignard A, Battistella P, Guendouz S, Houyel L, Para M, Flecher E, Gay A, Épailly É, Dambrin C, Lam K, Ka-Lai C, Cho Y, Choi J, Kim J, Coats L, Crossland D, Mumford L, Hakmi S, Sivathasan C, Fabritz L, Schubert S, Gummert J, Hübler M, Jacksch P, Zuckermann A, Laufer G, Baumgartner H, Giamberti A, Reichenspurner H, Kirchhof P
ESC HEART FAIL. 2021;8(6):5542-5550.

Medical Therapy in Arrhythmogenic Right Ventricular Cardiomyopathy
Sommerfeld L, Aljehani A, Kalla M, Fabritz L
2021. Current Concepts in Arrhythmogenic Cardiomyopathy, Second Edition. Brunckhorst C, Duru F, Saguner A (Hrsg.). 2. Aufl. Minneapolis, United States: Cardiotext Publishing, 127-134.

Detection of unknown atrial fibrillation by prolonged ECG monitoring in an all-comer patient cohort and association with clinical and Holter variables
Jawad-Ul-Qamar M, Chua W, Purmah Y, Nawaz M, Varma C, Davis R, Maher A, Fabritz L, Kirchhof P
OPEN HEART. 2020;7(1):.

Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5
Kloosterman M, Chua W, Fabritz L, Al-Khalidi H, Schotten U, Nielsen J, Piccini J, Di Biase L, Häusler K, Todd D, Mont L, Van Gelder I, Kirchhof P
EUROPACE. 2020;22(7):1026-1035.

Temporal irregularity quantification and mapping of optical action potentials using wave morphology similarity
O'Shea C, Winter J, Holmes A, Johnson D, Correia J, Kirchhof P, Fabritz L, Rajpoot K, Pavlovic D
PROG BIOPHYS MOL BIO. 2020;157:84-93.

Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes?
Peeters F, Dudink E, Weijs B, Fabritz L, Chua W, Kietselaer B, Wildberger J, Meex S, Kirchhof P, Crijns H, Schurgers L
FRONT CELL DEV BIOL. 2020;8:.

Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation
Reyat J, Chua W, Cardoso V, Witten A, Kastner P, Kabir S, Sinner M, Wesselink R, Holmes A, Pavlovic D, Stoll M, Kääb S, Gkoutos G, de Groot J, Kirchhof P, Fabritz L
JCI INSIGHT. 2020;5(16):.

Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation
van Ouwerkerk A, Hall A, Kadow Z, Lazarevic S, Reyat J, Tucker N, Nadadur R, Bosada F, Bianchi V, Ellinor P, Fabritz L, Martin J, de Laat W, Kirchhof P, Moskowitz I, Christoffels V
CIRC RES. 2020;127(1):34-50.

JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling
Winters J, von Braunmuhl M, Zeemering S, Gilbers M, Brink T, Scaf B, Guasch E, Mont L, Batlle M, Sinner M, Hatem S, Mansour M, Fabritz L, Sommerfeld L, Kirchhof P, Isaacs A, Stoll M, Schotten U, Verheule S
SCI REP-UK. 2020;10(1):.

Letzte Aktualisierung aus dem FIS: 23.07.2025 - 00:33 Uhr

Director

Assistance

Foto Gabi Wettengel

Gabi Wettengel

Project Assistance

g.wettengel@uke.de

+49 (0) 40 7410 - 50640

Research

Prof. Dr. Dr. Marc Hirt

Prof. Dr. Dr. Marc Hirt

Assistant Professor of Pharmacology

m.hirt@uke.de

Foto Dr. Vaishnavi Ameya Murukutla

Dr. Vaishnavi Ameya Murukutla

Project Management

v.murukutla@uke.de

+49 (0) 40 7410 - 50313

Hartwig Wieboldt

Hartwig Wieboldt

Research Lab Technician

h.wieboldt@uke.de

+49 (0) 40 7410 - 50959

Christoph Al-Taie

Data Scientist, PhD student

c.al-taie@uke.de

Foto Julius Ridder

Julius Ridder

PhD student

j.ridder@uke.de

Dr. Muhammed Sönmez

Dr. Muhammed Sönmez

Postdoc

m.soenmez@uke.de

Foto Ellen Thiemann

Ellen Thiemann

PhD student

e.thiemann@uke.de

Foto Silke van Elferen

Silke van Elferen

PhD student

S.van-Elferen@uke.de

Dr. Lisa Fortmüller

Veterinarian

l.fortmueller@uke.de

Foto Kyra Lachmann

Kyra Lachmann

MD student

Kyra.Lachmann.ext@uke.de

Foto Sandro Jäckle

Sandro Jäckle

MD student

s.jaeckele.ext@uke.de

Lukas von Hacht

Lukas von Hacht

MD student

L.von-Hacht@uke.de

Team Abroad

Dr. Laura Bravo

l.bravo@bham.ac.uk

Alumni

Dr. Winnie Chua

Dr. Deborah Delbue

Dr. Paulina Sander

  • Adresse Anfahrt
    How to reach us

    University Medical Center Hamburg-Eppendorf
    University Center of Cardiovascular Science (UCCS)
    Campus Forschung I, Building N27, 3rd floor
    Martinistr. 52
    20246 Hamburg / Germany