UKE - UCCS - Research Group Lang

Research Group Lang

Risk stratification of congenital heart disease

Innovative devices and materials for patients with congenital heart disease

Name: PD Dr. Nora Lang
Department/Center/Institute: University Heart and Vascular Center Hamburg (UHZ),
Pediatric Cardiology
Email: n.lang@uke.de
Phone: +49 (0) 40 7410 - 53718

Research Focus and Main research questions

Our Research Group focuses on two different areas.
First, we aim to optimize risk stratification of congenital heart disease by integrating protein- and microRNA-based biomarkers with different imaging modalities and clinical outcome variables.
Specifically, we focus on risk stratification of patients with Tetralogy of Fallot and Univentricular Circulation.

Secondly, we aim to develop novel, innovative devices and materials for patients with congenital heart disease. Specifically, we aim to personalize pulmonary flow restrictors (PFR) for patients with single ventricle physiology. These next generation devices are supposed to match individual hemodynamic requirements and explore the potential for self-adapting concepts that adapt dynamically to the changing physiology and hemodynamics of the patient. In addition, we are interested in evaluation of biodegradable patch materials and tissue adhesives for novel therapeutic approaches.

Research Projects

Risk stratification of patients with fontan circulation by protein- and miRNA-based biomarkers in combination with cardiac imaging and clinical outcome variables (Paul Lampel)
Risk stratification of patients with tetralogy of Fallot by integrating protein- and miRNA-based biomarkers in combination with cardiac imaging and clinical outcome variables (Palle Jürgensen)
Personalization of Pulmonary Flow Restrictors for Patients with Single Ventricle Physiology

Methods
Publications
Recent Funding

Methods
- Cardiac Imaging
- Biomarker analysis
- Benchtop testing
- Computational Modeling
- Large Animal Models

Publications

Lang N, Staffa SJ, Zurakowski D, Sperotto F, Shea M, Baird CW, Emani S, Del Nido PJ, Marx GR. Clinical and 2D/3D-Echo Cardiography Determinants of Mitral Valve Reoperation in Children With Congenital Mitral Valve Disease. JACC Adv. 2024 17;3(8):101081.
Sperotto F*, Lang N*, Nathan M, Kaza A, Hoganson DM, Valencia E, Odegard K, Allan CK, da Cruz EM, Del Nido PJ, Emani SM, Baird C, Maschietto N. Transcatheter Palliation With Pulmonary Artery Flow Restrictors in Neonates With Congenital Heart Disease: Feasibility, Outcomes, and Comparison With a Historical Hybrid Stage 1 Cohort. Circ Cardiovasc Interv. 2023 Dec; 16(12):e013383. *Both authors contributed equally to the manuscript.
Kizilski SB, Recco DP, Sperotto F, Lang N, Hammer PE, Baird CW, Maschietto N, Hoganson DM. Transcatheter Pulmonary Artery Banding in High-Risk NeonatesTranscatheter Pulmonary Artery Banding in High-Risk Neonates: In-Vitro Study Provoked by Initial Clinical Experience. Cardiovasc Eng Technol. 2023 Oct;14(5):640-654.
Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Casar Berazaluce AM, Bueno A, Lang N, Pereira MJ, Feins E, Wasserman S, O'Cearbhaill ED, Vasilyev NV, Mooney DJ, Karp JM, Del Nido PJ, Walsh CJ. A light-reflecting balloon catheter for atraumatic tissue defect repair. Sci Transl Med. 2015 Sep 23;7(306):306ra149. doi: 10.1126/scitranslmed.aaa2406
Lang N, Merkel E, Fuchs F, Schumann D, Klemm D, Kramer F, Mayer-Wagner S, Schroeder C, Freudenthal F, Netz H, Kozlik-Feldmann R, Sigler M. Bacterial nanocellulose as a new patch material for closure of ventricular septal defects in a pig model. Eur J Cardiothorac Surg. 2015 Jun;47(6):1013-21.
Lang N*, Pereira MJ*, Lee Y, Friehs I, Vasilyev NV, Feins EN, Ablasser K, O’Cearbhaill E, Xu C, Fabozzo A, Padera R, Wasserman S, Freudenthal F, Ferreira LS , Langer RS, Jeffrey M. Karp*, Pedro J. del Nido*. *Both authors contributed equally to the manuscript. A biocompatible, hydrophobic, light-activated adhesive for minimally invasive repair of cardiovascular defects. Sci Transl Med. 2014 Jan 8;6(218):218ra6.

Recent Funding

2013-2023 Deutsche Herzstiftung: “Verschluss von kardiovaskulären Defekten mit einem biokompatiblen lichtaktivierbaren Gewebekleber“
2015-2021 Tissium: Förderung der Projekte mit dem biokompatiblen und lichtaktivierbaren Gewebekleber von Tissium
2017 Promotionsprogramm „Translationale Medizin“ der Technischen Universität München:
Förderung des Projekts „Verschluss vom offenen Foramen ovale und Vorhofseptumdefekten mit Gewebeklebern“