Intestinal epithelia and myeloid immune cells shape colitis severity and colorectal carcinogenesis via High-mobility group box protein 1
Foelsch K, Pelczar P, Zierz E, Kondratowicz S, Qi M, Müller C, Alawi M, Huebener S, Clauditz T, Gagliani N, Huber S, Huebener P
J CROHNS COLITIS. 2024 [Epub ahead of print].

IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction
Shiri A, Zhang T, Bedke T, Zazara D, Zhao L, Lücke J, Sabihi M, Fazio A, Zhang S, Tauriello D, Batlle E, Steglich B, Kempski J, Agalioti T, Nawrocki M, Xu Y, Riecken K, Liebold I, Brockmann L, Konczalla L, Bosurgi L, Mercanoglu B, Seeger P, Küsters N, Lykoudis P, Heumann A, Arck P, Fehse B, Busch P, Grotelüschen R, Mann O, Izbicki J, Hackert T, Flavell R, Gagliani N, Giannou A, Huber S
J HEPATOL. 2024;80(4):634-644.

Diet and immune response: how today's plate shapes tomorrow's health
Siracusa F, Tintelnot J, Cortesi F, Gagliani N
TRENDS IMMUNOL. 2024;45(1):4-10.

A protective effect of inflammatory bowel disease on the severity of sclerosing cholangitis
Stumme F, Steffens N, Steglich B, Mathies F, Nawrocki M, Sabihi M, Soukou-Wargalla S, Göke E, Kempski J, Fründt T, Weidemann S, Schramm C, Gagliani N, Huber S, Bedke T
FRONT IMMUNOL. 2024;15:1307297.

Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection
Torcellan T, Friedrich C, Doucet-Ladevèze R, Ossner T, Solé V, Riedmann S, Ugur M, Imdahl F, Rosshart S, Arnold S, Gomez de Agüero M, Gagliani N, Flavell R, Backes S, Kastenmüller W, Gasteiger G
IMMUNITY. 2024;57(1):124-140.e7.

Purinergic enzymes on extracellular vesicles: immune modulation on the go
Winzer R, Nguyen D, Schoppmeier F, Cortesi F, Gagliani N, Tolosa E
FRONT IMMUNOL. 2024;15:1362996.

TH17 cell immune adaptation
Agalioti T, Cortesi F, Gagliani N
CURR OPIN IMMUNOL. 2023;83:102333.

Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
Bertram T, Reimers D, Lory N, Schmidt C, Schmid J, C Heinig L, Bradtke P, Rattay G, Zielinski S, Hellmig M, Bartsch P, Rohde H, Nuñez S, Rosemblatt M, Bono M, Gagliani N, Sandrock I, Panzer U, Krebs C, Meyer-Schwesinger C, Prinz I, Mittrücker H
P NATL ACAD SCI USA. 2023;120(1):e2210490120.

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
Giannou A, Kempski J, Shiri A, Lücke J, Zhang T, Zhao L, Zazara D, Cortesi F, Riecken K, Amezcua Vesely M, Low J, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens K, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, Sabihi M, Huber F, Reeh M, Grass J, Wahib R, Seese H, Stüben B, Fard-Aghaie M, Duprée A, Scognamiglio P, Plitzko G, Meiners J, Soukou S, Wittek A, Manthey C, Maroulis I, Arck P, Perez D, Gao B, Zarogiannis S, Strowig T, Pasqualini R, Arap W, Gosálvez J, Kobold S, Prinz I, Guse A, Tachezy M, Ghadban T, Heumann A, Li J, Melling N, Mann O, Izbicki J, Pantel K, Schumacher U, Lohse A, Flavell R, Gagliani N, Huber S
IMMUNITY. 2023;56(1):125-142.e12.

IL-22BP controls the progression of liver metastasis in colorectal cancer
Giannou A, Kempski J, Zhang T, Lücke J, Shiri A, Zazara D, Belios I, Machicote A, Seeger P, Agalioti T, Tintelnot J, Sagebiel A, Tomczak M, Bauditz L, Bedke T, Kocheise L, Mercanoglu B, Fard-Aghaie M, Giorgakis E, Lykoudis P, Pikouli A, Grass J, Wahib R, Bardenhagen J, Brunswig B, Heumann A, Ghadban T, Duprée A, Tachezy M, Melling N, Arck P, Stringa P, Gentilini M, Gondolesi G, Nakano R, Thomson A, Perez D, Li J, Mann O, Izbicki J, Gagliani N, Maroulis I, Huber S
FRONT ONCOL. 2023;13:1170502.

DISCERN: deep single-cell expression reconstruction for improved cell clustering and cell subtype and state detection
Hausmann F, Ergen C, Khatri R, Marouf M, Hänzelmann S, Gagliani N, Huber S, Machart P, Bonn S
GENOME BIOL. 2023;24(1):212.

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens
Kylies D, Zimmermann M, Haas F, Schwerk M, Kuehl M, Brehler M, Czogalla J, Hernandez L, Konczalla L, Okabayashi Y, Menzel J, Edenhofer I, Mezher S, Aypek H, Dumoulin B, Wu H, Hofmann S, Kretz O, Wanner N, Tomas N, Krasemann S, Glatzel M, Kuppe C, Kramann R, Banjanin B, Schneider R, Urbschat C, Arck P, Gagliani N, van Zandvoort M, Wiech T, Grahammer F, Sáez P, Wong M, Bonn S, Huber T, Puelles V
NAT NANOTECHNOL. 2023;18(4):336-342.

Intestinal IL-1β Plays a Role in Protecting against SARS-CoV-2 Infection
Lücke J, Heinrich F, Malsy J, Meins N, Schnell J, Böttcher M, Nawrocki M, Zhang T, Bertram F, Sabihi M, Kempski J, Blankenburg T, Duprée A, Reeh M, Wolter S, Mann O, Izbicki J, Lohse A, Gagliani N, Lütgehetmann M, Bunders M, Altfeld M, Sauter G, Giannou A, Krasemann S, Ondruschka B, Huber S
J IMMUNOL. 2023;211(6):1052-1061.

Short-term dietary changes can result in mucosal and systemic immune depression
Siracusa F, Schaltenberg N, Kumar Y, Lesker T, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks B, Bönisch F, Fischer A, Scognamiglio P, Pauly M, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker H, Kretz O, Guse A, Izbicki J, Lassen K, Strowig T, Schweizer M, Villablanca E, Elinav E, Huber S, Heeren J, Gagliani N
NAT IMMUNOL. 2023;24(9):1473-1486.

Tr1 Cells Emerge and Suppress Effector Th17 Cells in Glomerulonephritis
Soukou-Wargalla S, Kilian C, Velasquez L, Machicote A, Letz P, Tran H, Domanig S, Bertram F, Stumme F, Bedke T, Giannou A, Kempski J, Sabihi M, Song N, Paust H, Borchers A, Garcia Perez L, Pelczar P, Liu B, Ergen C, Steglich B, Muscate F, Huber T, Panzer U, Gagliani N, Krebs C, Huber S
J IMMUNOL. 2023;211(11):1669-1679.

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Tintelnot J, Xu Y, Lesker T, Schönlein M, Konczalla L, Giannou A, Pelczar P, Kylies D, Puelles V, Bielecka A, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring T, Trajkovic-Arsic M, Siveke J, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu F, Güngör C, Stein A, Izbicki J, Bokemeyer C, Sinn M, Kimmelman A, Huber S, Gagliani N
NATURE. 2023;615(7950):168-174.

Fatty acid-binding protein-4 (FABP4) and matrix metalloproteinase-9 (MMP9) as predictive values for nonalcoholic steatohepatitis (NASH)
Wagner J, Kumar Y, Lautenbach A, von Kroge P, Wolter S, Mann O, Izbicki J, Gagliani N, Duprée A
LIPIDS HEALTH DIS. 2023;22(1):1.

A Gradient of Intestinal Inflammation in Primary Sclerosing Cholangitis
Wittek A, Steglich B, Casar C, Seiz O, Huber P, Ehlken H, Reher D, Wende S, Bedke T, Kempski J, Böttcher M, Bang C, Thingholm L, Krech T, Lohse A, Sauter G, Rösch T, Franke A, Schramm C, Gagliani N, Pelczar P, Huber S
INFLAMM BOWEL DIS. 2023 [Epub ahead of print];1-11.

Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH
Woestemeier A, Scognamiglio P, Zhao Y, Wagner J, Muscate F, Casar C, Siracusa F, Cortesi F, Agalioti T, Müller S, Sagebiel A, Konczalla L, Wahib R, Karstens K, Giannou A, Duprée A, Wolter S, Wong M, Mühlig A, Bielecka A, Bansal V, Zhang T, Mann O, Puelles V, Huber T, Lohse A, Izbicki J, Palm N, Bonn S, Huber S, Gagliani N
JCI INSIGHT. 2023;8(1):.

CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis
Zhang T, Wahib R, Zazara D, Lücke J, Shiri A, Kempski J, Zhao L, Agalioti T, Machicote A, Giannou O, Belios I, Jia R, Zhang S, Tintelnot J, Seese H, Grass J, Mercanoglu B, Stern L, Scognamiglio P, Fard-Aghaie M, Seeger P, Wakker J, Kemper M, Brunswig B, Duprée A, Lykoudis P, Pikouli A, Giorgakis E, Stringa P, Lausada N, Gentilini M, Gondolesi G, Bachmann K, Busch P, Grotelüschen R, Maroulis I, Arck P, Nakano R, Thomson A, Ghadban T, Tachezy M, Melling N, Achilles E, Puelles V, Nickel F, Hackert T, Mann O, Izbicki J, Li J, Gagliani N, Huber S, Giannou A
ONCOIMMUNOLOGY. 2023;12(1):2269634.

Tissue-resident memory T cells in the kidney
Asada N, Ginsberg P, Gagliani N, Mittrücker H, Panzer U
SEMIN IMMUNOPATHOL. 2022;44(6):801-811.

Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection
Bartsch P, Kilian C, Hellmig M, Paust H, Borchers A, Sivayoganathan A, Enk L, Zhao Y, Shaikh N, Büttner H, Wong M, Puelles V, Wiech T, Flavell R, Huber T, Turner J, Bonn S, Huber S, Gagliani N, Mittrücker H, Rohde H, Panzer U, Krebs C
PLOS PATHOG. 2022;18(4):e1010430.

A Critical Role of the IL-22-IL-22 Binding Protein Axis in Hepatocellular Carcinoma
Giannou A, Lücke J, Kleinschmidt D, Shiri A, Steglich B, Nawrocki M, Zhang T, Zazara D, Kempski J, Zhao L, Giannou O, Agalioti T, Brockmann L, Bertram F, Sabihi M, Böttcher M, Ewald F, Schulze K, von Felden J, Machicote A, Maroulis I, Arck P, Graß J, Mercanoglu B, Reeh M, Wolter S, Tachezy M, Seese H, Theodorakopoulou M, Lykoudis P, Heumann A, Uzunoglu F, Ghadban T, Mann O, Izbicki J, Li J, Duprée A, Melling N, Gagliani N, Huber S
CANCERS. 2022;14(24):.

The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium
Jimenez M, Clark M, Wright J, Michieletto M, Liu S, Erickson I, Dohnalova L, Uhr G, Tello-Cajiao J, Joannas L, Williams A, Gagliani N, Bewtra M, Tomov V, Thaiss C, Henao-Mejia J
J EXP MED. 2022;219(12):.

The spatial transcriptomic landscape of the healing mouse intestine following damage
Parigi S, Larsson L, Das S, Ramirez Flores R, Frede A, Tripathi K, Diaz O, Selin K, Morales R, Luo X, Monasterio G, Engblom C, Gagliani N, Saez-Rodriguez J, Lundeberg J, Villablanca E
NAT COMMUN. 2022;13(1):.

A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids
Rohde J, Fuh M, Evangelakos I, Pauly M, Schaltenberg N, Siracusa F, Gagliani N, Tödter K, Heeren J, Worthmann A
METABOLITES. 2022;12(2):.

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
Schepanski S, Chini M, Sternemann V, Urbschat C, Thiele K, Sun T, Zhao Y, Poburski M, Woestemeier A, Thieme M, Zazara D, Alawi M, Fischer N, Heeren J, Vladimirov N, Woehler A, Puelles V, Bonn S, Gagliani N, Hanganu-Opatz I, Arck P
NAT COMMUN. 2022;13(1):.

Tissue Sampling and Homogenization with NIRL Enables Spatially Resolved Cell Layer Specific Proteomic Analysis of the Murine Intestine
Voß H, Moritz M, Pelczar P, Gagliani N, Huber S, Nippert V, Schlüter H, Hahn J
INT J MOL SCI. 2022;23(11):.

CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival
Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford A, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy K, Gagliani N, Flavell R, Waisman A, Huber S
CELL REP. 2022;38(13):.

Skin-resident innate lymphoid cells converge on a pathogenic effector state
Bielecki P, Riesenfeld S, Hütter J, Torlai Triglia E, Kowalczyk M, Ricardo-Gonzalez R, Lian M, Amezcua Vesely M, Kroehling L, Xu H, Slyper M, Muus C, Ludwig L, Christian E, Tao L, Kedaigle A, Steach H, York A, Skadow M, Yaghoubi P, Dionne D, Jarret A, McGee H, Porter C, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley R, Regev A, Flavell R
NATURE. 2021;592(7852):128-132.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M, Andrä I, Andreata F, Annunziato F, Arranz E, Bacher P, Bari S, Barnaba V, Barros-Martins J, Baumjohann D, Beccaria C, Bernardo D, Boardman D, Borger J, Böttcher C, Brockmann L, Burns M, Busch D, Cameron G, Cammarata I, Cassotta A, Chang Y, Chirdo F, Christakou E, Čičin-Šain L, Cook L, Corbett A, Cornelis R, Cosmi L, Davey M, De Biasi S, De Simone G, Del Zotto G, Delacher M, Di Rosa F, Santo J, Diefenbach A, Dong J, Dörner T, Dress R, Dutertre C, Eckle S, Eede P, Evrard M, Falk C, Feuerer M, Fillatreau S, Fiz-Lopez A, Follo M, Foulds G, Fröbel J, Gagliani N, Galletti G, Gangaev A, Garbi N, Garrote J, Geginat J, Gherardin N, Gibellini L, Ginhoux F, Godfrey D, Gruarin P, Haftmann C, Hansmann L, Harpur C, Hayday A, Heine G, Hernández D, Herrmann M, Hoelsken O, Huang Q, Huber S, Huber J, Huehn J, Hundemer M, Hwang W, Iannacone M, Ivison S, Jäck H, Jani P, Keller B, Kessler N, Ketelaars S, Knop L, Knopf J, Koay H, Kobow K, Kriegsmann K, Kristyanto H, Krueger A, Kuehne J, Kunze-Schumacher H, Kvistborg P, Kwok I, Latorre D, Lenz D, Levings M, Lino A, Liotta F, Long H, Lugli E, MacDonald K, Maggi L, Maini M, Mair F, Manta C, Manz R, Mashreghi M, Mazzoni A, McCluskey J, Mei H, Melchers F, Melzer S, Mielenz D, Monin L, Moretta L, Multhoff G, Muñoz L, Muñoz-Ruiz M, Muscate F, Natalini A, Neumann K, Ng L, Niedobitek A, Niemz J, Almeida L, Notarbartolo S, Ostendorf L, Pallett L, Patel A, Percin G, Peruzzi G, Pinti M, Pockley A, Pracht K, Prinz I, Pujol-Autonell I, Pulvirenti N, Quatrini L, Quinn K, Radbruch H, Rhys H, Rodrigo M, Romagnani C, Saggau C, Sakaguchi S, Sallusto F, Sanderink L, Sandrock I, Schauer C, Scheffold A, Scherer H, Schiemann M, Schildberg F, Schober K, Schoen J, Schuh W, Schüler T, Schulz A, Schulz S, Schulze J, Simonetti S, Singh J, Sitnik K, Stark R, Starossom S, Stehle C, Szelinski F, Tan L, Tarnok A, Tornack J, Tree T, van Beek J, van de Veen W, van Gisbergen K, Vasco C, Verheyden N, von Borstel A, Ward-Hartstonge K, Warnatz K, Waskow C, Wiedemann A, Wilharm A, Wing J, Wirz O, Wittner J, Yang J, Yang J
EUR J IMMUNOL. 2021;51(12):2708-3145.

Functional heterogeneity of CD4+ T cells in liver inflammation
Muscate F, Woestemeier A, Gagliani N
SEMIN IMMUNOPATHOL. 2021;43(4):549-561.

Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide—Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice
Nawrocki M, Lory N, Bedke T, Stumme F, Diercks B, Guse A, Meier C, Gagliani N, Mittrücker H, Huber S
CELLS-BASEL. 2021;10(11):.

Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis
Poch T, Krause J, Casar C, Liwinski T, Glau L, Kaufmann M, Ahrenstorf A, Hess L, Ziegler A, Martrus G, Lunemann S, Sebode M, Li J, Schwinge D, Krebs C, Franke A, Friese M, Oldhafer K, Fischer L, Altfeld M, Lohse A, Huber S, Tolosa E, Gagliani N, Schramm C
J HEPATOL. 2021;75(2):414-423.

Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells
Roy U, de Oliveira R, Galvez E, Gronow A, Basic M, Perez L, Gagliani N, Bleich A, Huber S, Strowig T
FRONT IMMUNOL. 2021;12:671331.

Carbon Monoxide Suppresses Neointima Formation in Transplant Arteriosclerosis by Inhibiting Vascular Progenitor Cell Differentiation
Sakihama H, Lee G, Chin B, Csizmadia E, Gallo D, Qi Y, Gagliani N, Wang H, Bach F, Otterbein L
ARTERIOSCL THROM VAS. 2021;41(6):1915-1927.

IL-17 receptor c signaling controls CD4⁺T_H17 immune responses and tissue injury in immune-mediated kidney diseases
Schmidt T, Luebbe J, Kilian C, Riedel J, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell R, Gagliani N, Pelzcar P, Huber S, Huber T, Turner J, Paust H, Krebs C, Panzer U
J AM SOC NEPHROL. 2021;32(12):3081-3098.

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
Schneider E, Winzer R, Rissiek A, Ricklefs I, Meyer-Schwesinger C, Ricklefs F, Bauche A, Behrends J, Reimer R, Brenna S, Wasielewski H, Lauten M, Rissiek B, Puig B, Cortesi F, Magnus T, Fliegert R, Müller C, Gagliani N, Tolosa E
NAT COMMUN. 2021;12(1):5911.

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19
Schultheiß C, Paschold L, Willscher E, Simnica D, Wöstemeier A, Muscate F, Wass M, Eisenmann S, Dutzmann J, Keyßer G, Gagliani N, Binder M
ISCIENCE. 2021;24(11):.

Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts
Simnica D, Schultheiß C, Mohme M, Paschold L, Willscher E, Fitzek A, Püschel K, Matschke J, Ciesek S, Sedding D, Zhao Y, Gagliani N, Maringer Y, Walz J, Heide J, Schulze-Zur-Wiesch J, Binder M
CLIN TRANSL IMMUNOL. 2021;10(9):e1340.

IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression
Stein S, Henze L, Poch T, Carambia A, Krech T, Preti M, Schuran F, Reich M, Keitel V, Fiorotto R, Strazzabosco M, Fischer L, Li J, Müller L, Wagner J, Gagliani N, Herkel J, Schwinge D, Schramm C
J HEPATOL. 2021;74(4):919-930.

Efferocytosis fuels malignant pleural effusion through TIMP1
Zhao L, Giannou A, Xu Y, Shiri A, Liebold I, Steglich B, Bedke T, Zhang T, Lücke J, Scognamiglio P, Kempski J, Woestemeier A, Chen J, Agalioti T, Zazara D, Lindner D, Janning M, Hennigs J, Jagirdar R, Kotsiou O, Zarogiannis S, Kobayashi Y, Izbicki J, Ghosh S, Rothlin C, Bosurgi L, Huber S, Gagliani N
SCI ADV. 2021;7(33):.

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Zhao Y, Kilian C, Turner J, Bosurgi L, Roedl K, Bartsch P, Gnirck A, Cortesi F, Schultheiß C, Hellmig M, Enk L, Hausmann F, Borchers A, Wong M, Paust H, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur Wiesch J, Puelles V, Sperhake J, Addo M, Lohse A, Binder M, Huber S, Huber T, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs C
SCI IMMUNOL. 2021;6(56):.

NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
Babic M, Dimitropoulos C, Hammer Q, Stehle C, Heinrich F, Sarsenbayeva A, Eisele A, Durek P, Mashreghi M, Lisnic B, Van Snick J, Löhning M, Fillatreau S, Withers D, Gagliani N, Huber S, Flavell R, Polic B, Romagnani C
J EXP MED. 2020;217(8):.

Systemic interleukin 10 levels indicate advanced stages while interleukin 17A levels correlate with reduced survival in esophageal adenocarcinomas
Karstens K, Kempski J, Giannou A, Freiwald E, Reeh M, Tachezy M, Izbicki J, Lohse A, Gagliani N, Huber S, Pelczar P
PLOS ONE. 2020;15(4):e0231833.

Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival
Karstens K, Kempski J, Giannou A, Pelczar P, Steglich B, Steurer S, Freiwald E, Woestemeier A, Konczalla L, Tachezy M, Reeh M, Bockhorn M, Perez D, Mann O, Lohse A, Roesch T, Izbicki J, Gagliani N, Huber S
CANCER IMMUNOL IMMUN. 2020;69(6):1043-1056.

IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
Kempski J, Giannou A, Riecken K, Zhao L, Steglich B, Lücke J, Garcia-Perez L, Karstens K, Wöstemeier A, Nawrocki M, Pelczar P, Witkowski M, Nilsson S, Konczalla L, Shiri A, Kempska J, Wahib R, Brockmann L, Huber P, Gnirck A, Turner J, Zazara D, Arck P, Stein A, Simon R, Daubmann A, Meiners J, Perez D, Strowig T, Koni P, Kruglov A, Sauter G, Izbicki J, Guse A, Roesch T, Lohse A, Flavell R, Gagliani N, Huber S
GASTROENTEROLOGY. 2020;159(4):1417-1430.e3.

Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease
Krebs C, Reimers D, Zhao Y, Paust H, Bartsch P, Nuñez S, Rosemblatt M, Hellmig M, Kilian C, Borchers A, Enk L, Zinke M, Becker M, Schmid J, Klinge S, Wong M, Puelles V, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer M, Cohen C, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner J, Riedel J, Huber S, Gagliani N, Huber T, Wiech T, Rohde H, Bono M, Bonn S, Panzer U, Mittrücker H
SCI IMMUNOL. 2020;5(50):.

Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
Perez L, Kempski J, McGee H, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, Vesely M, Soukou S, Steglich B, Bedke T, Manthey C, Seiz O, Diercks B, Gnafakis S, Guse A, Perez D, Izbicki J, Gagliani N, Flavell R, Huber S
NAT COMMUN. 2020.

TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
Perez L, Kempski J, M McGee H, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, Vesely M, Soukou S, Steglich B, Bedke T, Manthey C, Seiz O, Diercks B, Gnafakis S, Guse A, Perez D, Izbicki J, Gagliani N, Flavell R, Huber S
NAT COMMUN. 2020;11(1):.

The induction and function of the anti-inflammatory fate of TH17 cells
Xu H, Agalioti T, Zhao J, Steglich B, Wahib R, Vesely M, Bielecki P, Bailis W, Jackson R, Perez D, Izbicki J, Licona-Limón P, Kaartinen V, Geginat J, Esplugues E, Tolosa E, Huber S, Flavell R, Gagliani N
NAT COMMUN. 2020;11(1):3334.

Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection
Amezcua Vesely M, Pallis P, Bielecki P, Low J, Zhao J, Harman C, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai P, Kaplan D, Weaver C, Kluger Y, Kowalczyk M, Iwasaki A, Pereira J, Esplugues E, Gagliani N, Flavell R
CELL. 2019;178(5):1176-1188.e15.

IL-10-producing T cells and their dual functions
Bedke T, Muscate F, Soukou S, Gagliani N, Huber S
SEMIN IMMUNOL. 2019;44:101335.

Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification
Czarnewski P, Parigi S, Sorini C, Diaz O, Das S, Gagliani N, Villablanca E
NAT COMMUN. 2019;10(1):2892.

Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza
Hartmann W, Brunn M, Stetter N, Gagliani N, Muscate F, Stanelle-Bertram S, Gabriel G, Breloer M
CELL REP. 2019;29(8):2243-2256.e4.

Human Fetal TNF-α-Cytokine-Producing CD4 Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life
Schreurs R, Baumdick M, Sagebiel A, Kaufmann M, Mokry M, Klarenbeek P, Schaltenberg N, Steinert F, van Rijn J, Drewniak A, The S, Bakx R, Derikx J, de Vries N, Corpeleijn W, Pals S, Gagliani N, Friese M, Middendorp S, Nieuwenhuis E, Reinshagen K, Geijtenbeek T, van Goudoever J, Bunders M
IMMUNITY. 2019;50(2):462-476.e8.

Dietary Habits and Intestinal Immunity: From Food Intake to CD4(+) T-H Cells
Siracusa F, Schaltenberg N, Villablanca E, Huber S, Gagliani N
FRONT IMMUNOL. 2019;9:3177.

Author Correction: Differential expression pattern of co-inhibitory molecules on CD4 T cells in uncomplicated versus complicated malaria.
Abel A, Steeg C, Aminkiah F, Addai-Mensah O, Addo M, Gagliani N, Casar C, Yar D, Owusu-Dabo E, Jacobs T, Mackroth M
SCI REP-UK. 2018;8(1):17587.

Differential expression pattern of co-inhibitory molecules on CD4(+) T cells in uncomplicated versus complicated malaria
Abel A, Steeg C, Aminkiah F, Addai-Mensah O, Addo M, Gagliani N, Casar C, Yar D, Owusu-Dabo E, Jacobs T, Mackroth M
SCI REP-UK. 2018;8(1):4789.

T17 cell plasticity: The role of dendritic cells and molecular mechanisms
Agalioti T, Villablanca E, Huber S, Gagliani N
J AUTOIMMUN. 2018;87:50-60.

Intestinal IFN-γ-producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease
Alfen J, Larghi P, Facciotti F, Gagliani N, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco C, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti M, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell R, Geginat J
J ALLERGY CLIN IMMUN. 2018;142(5):1537-1547.e8.

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells
Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson J, Antonson P, Roncarolo M, Villablanca E, Gagliani N, Huber S
NAT COMMUN. 2018;9(1):5457.

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3 Regulatory T Cells
Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber F, Roy U, Meyer T, Luetgehetmann M, von Petersdorff M, Seiz O, Herkel J, Schramm C, Flavell R, Gagliani N, Krebs C, Panzer U, Abdullah Z, Strowig T, Bedke T, Huber S
J IMMUNOL. 2018;201(12):3558-3568.

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases
Roncarolo M, Gregori S, Bacchetta R, Battaglia M, Gagliani N
IMMUNITY. 2018;49(6):1004-1019.

Commensal Bacteria-Specific CD4 T Cell Responses in Health and Disease
Sorini C, Cardoso R, Gagliani N, Villablanca E
FRONT IMMUNOL. 2018;9:2667.

Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease
Soukou S, Brockmann L, Bedke T, Gagliani N, Flavell R, Huber S
CRIT REV IMMUNOL. 2018;38(5):415-431.

Recipe for IBD: can we use food to control inflammatory bowel disease
Witkowski M, Witkowski M, Gagliani N, Huber S
SEMIN IMMUNOPATHOL. 2018;40(2):145-156.

Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice
Wolters-Eisfeld G, Mercanoglu B, Hofmann B, Wolpers T, Schnabel C, Harder S, Steffen P, Bachmann K, Steglich B, Schrader J, Gagliani N, Schlüter H, Güngör C, Izbicki J, Wagener C, Bockhorn M
EXP MOL MED. 2018;50(10):1-13.

HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer
Bogoevska V, Wolters-Eisfeld G, Hofmann B, El Gammal A, Mercanoglu B, Gebauer F, Vashist Y, Bogoevski D, Perez D, Gagliani N, Izbicki J, Bockhorn M, Güngör C
ONCOGENE. 2017;36(17):2394-2404.

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Bosurgi L, Cao Y, Cabeza-Cabrerizo M, Tucci A, Hughes L, Kong Y, Weinstein J, Licona-Limon P, Schmid E, Pelorosso F, Gagliani N, Craft J, Flavell R, Ghosh S, Rothlin C
SCIENCE. 2017;356(6342):1072-1076.

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo
Brockmann L, Gagliani N, Steglich B, Giannou A, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan Y, Esplugues E, Battaglia M, Krebs C, Flavell R, Huber S
J IMMUNOL. 2017;198(3):1130-1141.

Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis
Brockmann L, Giannou A, Gagliani N, Huber S
INT J MOL SCI. 2017;18(5):.

Basic Aspects of T Helper Cell Differentiation
Gagliani N, Huber S
Methods Mol Biol. 2017;1514:19-30.

CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity
Huber S, Gagliani N, O'Connor W, Geginat J, Caprioli F
MEDIAT INFLAMM. 2017;2017:7083153.

TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis
Kempski J, Brockmann L, Gagliani N, Huber S
FRONT IMMUNOL. 2017;8:1373.

A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury
Kleinschmidt D, Giannou A, McGee H, Kempski J, Steglich B, Huber F, Ernst T, Shiri A, Wegscheid C, Tasika E, Hübener P, Huber P, Bedke T, Steffens N, Agalioti T, Fuchs T, Noll J, Lotter H, Tiegs G, Lohse A, Axelrod J, Galun E, Flavell R, Gagliani N, Huber S
J IMMUNOL. 2017;199(12):4078-4090.

Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development
Yu H, Gagliani N, Ishigame H, Huber S, Zhu S, Esplugues E, Herold K, Wen L, Flavell R
P NATL ACAD SCI USA. 2017;114(39):10443-10448.

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus
Facciotti F, Gagliani N, Häringer B, Alfen J, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti M, Stölzel K, Romagnani C, Moroni G, Ingegnoli F, Torretta S, Pignataro L, Annoni A, Russo F, Pagani M, Abrignani S, Meroni P, Flavell R, Geginat J
J ALLERGY CLIN IMMUN. 2016;137(1):318-321.e5.

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer
Geginat J, Larghi P, Paroni M, Nizzoli G, Penatti A, Pagani M, Gagliani N, Meroni P, Abrignani S, Flavell R
CYTOKINE GROWTH F R. 2016;30:87-93.

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.

A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease
Pelczar P, Witkowski M, Perez L, Kempski J, Hammel A, Brockmann L, Kleinschmidt D, Wende S, Haueis C, Bedke T, Krasemann S, Steurer S, Booth C, Busch C, König A, Rauch U, Benten D, Izbicki J, Rösch T, Lohse A, Strowig T, Gagliani N, Flavell R, Huber S
SCIENCE. 2016;354(6310):358-362.

Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice
Fousteri G, Jofra T, Di Fonte R, Gagliani N, Morsiani C, Stabilini A, Battaglia M
DIABETOLOGIA. 2015;58(6):1319-28.

All in (IL-) 1?
Gagliani N, Battaglia M
TRANSPLANTATION. 2015;99(11):2235-6.

Intestinal Regulatory CD4+ T cells
Gagliani N, Huber S, Flavell R
2015. Mucosal Immunology. Mestecky J, Strober W, Russell M, Cheroutre H, Lambrecht B, Kelsall B (Hrsg.). 4. Aufl. Academic Press, 777-785.

Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice
Gagliani N, Jofra T, Posgai A, Atkinson M, Battaglia M
PLOS ONE. 2015;10(11):e0142318.

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Gagliani N, Vesely M, Iseppon A, Brockmann L, Xu H, Palm N, de Zoete M, Licona-Limón P, Paiva R, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire L, Cotton M, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell R
NATURE. 2015;523(7559):221-5.

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
Nowarski R, Jackson R, Gagliani N, de Zoete M, Palm N, Bailis W, Low J, Harman C, Graham M, Elinav E, Flavell R
CELL. 2015;163(6):1444-56.

MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis
Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch M, Chen X, Zhu W, Wang Y, Chen B, Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley J, Flavell R, Yao Y, Shen N
NAT COMMUN. 2015;6:7096.

Heterogeneous CD3 expression levels in differing T cell subsets correlate with the in vivo anti-CD3-mediated T cell modulation
Valle A, Barbagiovanni G, Jofra T, Stabilini A, Perol L, Baeyens A, Anand S, Cagnard N, Gagliani N, Piaggio E, Battaglia M
J IMMUNOL. 2015;194(5):2117-27.

FLUshing in the bathroom
Amezcua C, Gagliani N, Flavell R
J EXP MED. 2014;211(12):2328-9.

The Fire Within: Microbes Inflame Tumors
Gagliani N, Hu B, Huber S, Elinav E, Flavell R
CELL. 2014;157(4):776-783.

Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota
Gagliani N, Palm N, de Zoete M, Flavell R
INT IMMUNOL. 2014;26(9):495-9.

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer
Bosurgi L, Bernink J, Delgado Cuevas V, Gagliani N, Joannas L, Schmid E, Booth C, Ghosh S, Rothlin C
P NATL ACAD SCI USA. 2013;110(32):13091-6.

T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response
Carrera Silva E, Chan P, Joannas L, Errasti A, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton J, Lemke G, Ghosh S, Rothlin C
IMMUNITY. 2013;39(1):160-70.

Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen
Gagliani N, Jofra T, Valle A, Stabilini A, Morsiani C, Gregori S, Deng S, Rothstein D, Atkinson M, Kamanaka M, Flavell R, Roncarolo M, Battaglia M
AM J TRANSPLANT. 2013;13(8):1963-75.

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection
Licona-Limón P, Henao-Mejia J, Temann A, Gagliani N, Licona-Limón I, Ishigame H, Hao L, Herbert D, Flavell R
IMMUNITY. 2013;39(4):744-57.

The Intestine: where amazing things happen.
Gagliani N, Huber S, Flavell R
CELL RES. 2012;22(2):277-279.

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
Hoshi N, Schenten D, Nish S, Walther Z, Gagliani N, Flavell R, Reizis B, Shen Z, Fox J, Iwasaki A, Medzhitov R
NAT COMMUN. 2012;3:1120.

Life, death, and miracles: Th17 cells in the intestine.
Huber S, Gagliani N, Flavell R
EUR J IMMUNOL. 2012;42(9):2238-2245.

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Huber S, Gagliani N, Zenewicz L, Huber F, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W, Murphy A, Valenzuela D, Yancopoulos G, Booth C, Cho J, Ouyang W, Abraham C, Flavell R
NATURE. 2012;491(7423):259-263.

Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID
Sauer A, Brigida I, Carriglio N, Hernandez R, Scaramuzza S, Clavenna D, Sanvito F, Poliani P, Gagliani N, Carlucci F, Tabucchi A, Roncarolo M, Traggiai E, Villa A, Aiuti A
BLOOD. 2012;119(6):1428-39.

Control of TH17 cells occurs in the small intestine.
Esplugues E, Huber S, Gagliani N, Hauser A, Town T, Wan Y, O'Connor W, Rongvaux A, Nico V, Haberman A, Iwakura Y, Kuchroo V, Kolls J, Bluestone J, Herold K, Flavell R
NATURE. 2011;475(7357):514-518.

Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
Gagliani N, Gregori S, Jofra T, Valle A, Stabilini A, Rothstein D, Atkinson M, Roncarolo M, Battaglia M
PLOS ONE. 2011;6(12):e28434.

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
Huber S, Gagliani N, Esplugues E, O'Connor W, Huber F, Chaudhry A, Kamanaka M, Kobayashi Y, Booth C, Rudensky A, Roncarolo M, Battaglia M, Flavell R
IMMUNITY. 2011;34(4):554-565.

Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.
Kamanaka M, Huber S, Zenewicz L, Gagliani N, Rathinam C, O'Connor W, Wan Y, Nakae S, Iwakura Y, Hao L, Flavell R
J EXP MED. 2011;208(5):1027-1040.

Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells
Tresoldi E, Dell'Albani I, Stabilini A, Jofra T, Valle A, Gagliani N, Bondanza A, Roncarolo M, Battaglia M
HAEMATOLOGICA. 2011;96(9):1357-65.

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation
Esposito M, Ruffini F, Bellone M, Gagliani N, Battaglia M, Martino G, Furlan R
J NEUROIMMUNOL. 2010;220(1-2):52-63.

Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant
Gagliani N, Jofra T, Stabilini A, Valle A, Atkinson M, Roncarolo M, Battaglia M
DIABETES. 2010;59(2):433-9.

Autoimmune diabetic patients undergoing allogeneic islet transplantation: are we ready for a regulatory T-cell therapy?
Gagliani N, Ferraro A, Roncarolo M, Battaglia M
IMMUNOL LETT. 2009;127(1):1-7.

Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson S, Gagliani N, Gallo D, Chen J, Bach F, Otterbein L
J IMMUNOL. 2007;178(9):5921-9.

Letzte Aktualisierung aus dem FIS: 02.05.2024 - 00:33 Uhr