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Day 1: 26th, September 2025 (9:00 am - 9:00 pm)
Opening
Welcome
Prof. Carsten Bokemeyer & Dr. Malte Kriegs & Prof. Robert McCullumsmith
09.00 - 09.30
Introductory Lecture I: The interplay between protein phosphorylation and protein ubiquitylation
Prof. Dr. Sir Philip Cohen, University of Dundee (UK)
09:30 - 10:15
Introductory Lecture II: Mechanisms in kinase regulation
Prof. Tilman Brummer, Freiburg (GER)
10:15 - 11:00
Coffee break | 11:00 - 12:00
Session I - Basic and experimental research
Key note lecture I: Kinomics in basic and experimental research
Prof. Dr. Christopher D. Willey, The University of Alabama (USA)
11:15 - 12:00
Proffered paper (selected abstracts)
PP1: Kinomics, a promising portal to deep understanding of cardiovascular disease and new druggable targets for intervention
Emiel P.C. van der Vorst, Univ. Aachen (GER)
12:00 - 12:15
PP2: Unlocking cellular language: a new lens on signal transduction pathways
Nadia Tavakoli, Univ. Bristol (UK)
12:15 - 12:30
PP3: Differential impact of Hepatitis Delta Virus replication and expression of viral antigens on the cellular kinome profile
Eberahrd Hildt; Paul-Ehrlich-Institut, Langen (GER); Univ. Potsdam (GER)
12:30 - 12:45
PP4: Distinct protein kinase activity across age and sex in murine organs
Colin Osterloh, Univ. Lübeck (GER)
12:45 - 13:00
PP5: Roles of GSK-3a and GSK-3b in T cell-mediated tumour rejection
Alison Taylor, Univ. Leeds (UK)
13:00 - 13:15
Lunch break | 13:15 - 14:15
Session II - Kinase inhibitors
Key note lecture II: Kinase inhibitors
Prof. Dr. Christian Peifer, University of Kiel (GER)
14:15 - 15:00
Proffered paper (selected abstracts)
PP6: Specicif inhibition of Src family kinases to radiosensitize head and neck tumors
Malte Kriegs, UKE Hamburg (GER)
15:00 - 15:15
PP7: Allosteric inhibition of Anaplastic Lymphoma Kinase (ALK) by single-domain antibodies
Nan Zhang, Univ. Leeds (UK)
15:15 - 15:30
PP8: Regulation of anti-tumor immunity by GSK-3; a potential target for immunotheapy
Jessica Murby, Univ. Leeds (UK)
15:30 - 15:45
PP9: CellEKT: a chemical proteomics platform to profile cellular kinase engagement
Joel Rüegger, Univ. Leiden
15:45 - 16:00
Coffee break | 16:00 - 16:15
Session III - Kinomics in precision medicine
Key note lecture III: Kinases in precision Medicine
Key note lecture: Prof. Nikolas von Bubnoff, Univ. Clinical Center Schleswig-Holstein (GER)
16:15 - 17:00
Special Talk I: Kinome profiling in precision oncology: A case report
Maximilian Christopeit, UKE Hamburg (GER)
17:00 - 17:15
Proffered paper (selected abstracts)
PP10: Targeting ERBB3 and AKT to overcome adaptive resistance in EML4-ALK-driven nonsmall cell lung cancer
Josephina Sampson, Univ. Leeds (UK)
17:15 - 17:30
PP11: Illuminating Kinome-specific Mechanisms that Control Metastasis-associated Networks in Human Melanoma Cells: PamGene-mediated Discovery of Novel “Undruggable” Kinases
Dimitrios Stravopodis, National and Kapodistrian University of Athens (GR)
17:30 - 17:45
PP12: Profiling the kinome in progressive multiple sclerosis
Kelly Hares, Univ. Bristol (UK)
17:45 - 18:00
Poster Session with Beer, Wine and Snacks | 18:00 - 21:00
Day 2: 27th, September 2025 (9:00 am - 18:15 pm; afterwards: Social Evening)
Good morning | 09:00 - 09:10 - Information and organisation
Out of the box
Out of the box 1: Phosphoproteomics in kinome research
Florian Bayer (LS Proteomik), Technical Univ. Munich (GER)
09:10 - 09:40
Out of the box 2: The Ba/F3 system in kinase research
Dr. Corinna Albers-Leischner, UKE Hamburg (GER)
09:40 - 10:10
Out of the box 3: Discovery Research – Screening Port Hamburg
Dr. Sheraz Gul, Fraunhofer-ITMP, Hamburg (GER)
10:10 - 10:40
Out of the box 4: DIANA kinase Panel: A high-troughput platfom for broad kinome inhibtor profiling
Alena Uvizl, DIANA Biotechnologies (CR)
10:40 - 11:00
Coffee Break | 11:00 - 11:15
Session IV - Brain
Key note lecture IV: Bioinformatic tools for studying Kinome data
Prof. Dr. Robert McCullumsmith, Univ. Toledo (USA)
11:15 - 12:00
Proffered paper (selected abstracts)
PP13: Perturbation of Cell-subtype specific Active Kinome Networks in Schizophrenia
Ali Imami, Univ. Toledo (USA)
12:00 - 12:15
PP14: Voluntary Exercise Reprograms Brain Protein Kinase Signaling and Endocannabinoid Networks: Emerging Individual and Sex Differences
LiLian Yuan, Des Moines Univ. (USA)
12:15 - 12:30
PP15: A Secretory Kinase Conducting Tumour–Immune Crosstalk in Glioblastoma
Febe Ferro, Univ. Dundee (UK)
12:30 - 12:45
PP16: Functional Kinase Clusters Reflect Medulloblastoma Molecular Subtypes and HighlightPotential Therapeutic Targets
Jenna Wandtke, UKE Hamburg (GER)
12:45 - 13:00
Lunch break | 13:00 - 14:00
Session V - Therapy response prediction
Key note lecture V: Kinome profiling for disease diagnosis and therapy response prediction.
Dr. Astrid Weiß, University of Gießen (GER)
14:10 - 14:55
Proffered paper (selected abstracts)
Special Talk II: New predictive mehtods on the horizon?!
Prof. John Groten, PamGene (NL)
14:55 - 15:15
PP17: Tyrosine kinase activity plays a crucial role in leukemia-supportive macrophages.
Viktoria Kohlhas, Univ. Cologn (GER)
15:15 - 15:30
PP18: Integrative Clinical and Population-Based Study of Kinome Profiling in Acute Leukemias: Toward Personalized Targeted Therapies
Eliza Głodkowska-Mrówka, Institute of Hematology and Transfusion Medicine Warschau (POL)
15:30 - 15:45
PP19: Kinome Array Profiling of Peripheral Blood Mononuclear Cells Uncovers Interindividual Variability in Kinase Activity Among Healthy Subjects
Hunter Eby, Univ. Toledo (USA)
15:45 - 16:00
Coffee break
Session VI - Kinases and environment
Key note lecture VI: Kinases and environment (preclinical models & microbiome)
Prof. Dr. Gwenny Fuhler, Erasmus Medical Center Rotterdam (NL)
16:15 - 17:00
Proffered paper (selected abstracts)
PP20: Kinome activity changes in models for muscle disease in a culture dish?
Elisabeth Ehler, King's College London (UK)
17:00 - 17:15
PP21: Analysis of the Plasticity of Circulating Tumor Cells Reveals Differentially Regulated Kinases During the Suspension-to-Adherent Transition
Manfred Jücker, UKE Hamburg (GER)
17:15 - 17:30
PP22: Exploring the post-Traumatic Brain Injury Serine/Threonine Kinome and its Implications in Electrophysiological Alterations in Mouse Cortex
Celine Gallagher, Univ. Mainz (GER)
17:30 - 17:45
PP23: Leishmania Casein Kinase 1.2: A Dual-Function Kinase at the Host–Pathogen Interface
Najma Rachidi, Institute Pasteur, Paris (FRA)
17:45 - 18:00
