Research Focus Areas

Placental Galectin-Glycan Networks in Pregnancy

The placenta is one of the most fascinating and critical organs in human life. It connects mother and child, regulates metabolism, modulates the immune system, and lays the foundation for the long-term health of both.

Our research investigates how galectins and glycan-based signaling networks control placental development and function. A particular focus lies on preeclampsia — one of the most severe pregnancy complications, characterized by impaired placentation, inflammatory processes, and vascular dysfunction. We aim to identify the molecular mechanisms that distinguish healthy from pathological pregnancy outcomes, thereby opening new avenues for diagnostics and therapy.

Funded by the German Research Foundation (DFG).

Galectins and Cardiovascular Health Following Pregnancy Complications

Pregnancy complications such as preeclampsia significantly increase the long-term risk of cardiovascular diseases for both mother and child.

We study the role of galectins as a key link between placental insufficiency and later cardiovascular disease. The goal of our work is to identify biomarkers and pathophysiological mechanisms that enable early risk assessment and the development of new prevention strategies.

Funded by the German Research Foundation (DFG).

SWEETTALK: Maternal-Placental Communication in Metabolic Disorders

Gestational diabetes is one of the most common pregnancy complications and can have far-reaching consequences for the health of both mother and child.

In the SWEETTALK project, we explore how metabolic changes influence communication between mother and placenta. The focus is on glycoimmunological signaling pathways and the central regulatory role of galectins in metabolism, inflammation, and fetal development.

Funded by the Federal Ministry of Research, Technology and Space (BMFTR) as part of the “Sexual and Reproductive Health in Overweight and Obesity – SRHOO” program.