What is the nature of interactions between host cell and specific emerging virus, and how do they contribute to pathogenesis?
There is a critical need for a detailed insight into the interactions between emerging viruses and the host cell environment. Leveraging the availability of excellent animal models, including humanized animal models, as well as biosafety laboratory (BSL) 4 facilities at the
Bernhard Nocht Institute for Tropical Medicine (BNITM)
and the
Friedrich-Loeffler-Institut (FLI)
and human organoid investigation systems, will allow for the study of virus-host interactions in complex in situ settings, building on and going beyond the molecular and cellular levels in simplified in vitro settings. The establishment of suitable animal models will be essential for risk assessment of severe zoonotic diseases and to provide stringent and high-quality models for antiviral and vaccine testing. In addition, the access to clinical samples will allow us to rapidly relate the in vitro and animal observations to human disease.
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