Working Group Behrendt


Name: Priv.-Doz. Dr. med. Christian-Alexander Behrendt
Clinic/Institute: Research Group GermanVasc, Department of Vascular Medicine
Email: ch.behrendt@uke.de
Phone: +49 (0) 40 7410 - 18087

Research Focus and Main research questions

The Research Group GermanVasc was founded in 2014 at the University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. We are primarily active in the field of health services research and quality improvement using registries and health insurance claims data. GermanVasc is deeply involved and embedded in several national and international collaborations comprising the VASCUNET committee of the European Society for Vascular Surgery (ESVS), the International Consortium of Vascular Registries (ICVR), as well as the Medical Device Epidemiology Network (MDEpiNet). To date, we published more than 70 original contributions using routinely collected data from insurance claims or registries on vascular interventions (e.g., on pharmacological treatment, open-surgical and endovascular interventions, medical devices, sex-related differences in care, and predictive risk modelling).

Research Projects

Between 2015 and 2021, we conducted four interdependent research projects in the field of the treatment of patients with peripheral arterial disease (principal investigator: Christian-Alexander Behrendt). These projects comprised a multicenter registry to determine everyday clinical practice in 74 German vascular centres (PSI study), a multistage real-world study using both data from registries and routinely collected claims data (CORONA study), a prospective cohort study on the complementary care of patients with symptomatic peripheral arterial disease (IDOMENEO study), and a multiprofessional consortial study on predictive risk modelling and its implications for data protection and liability (RABATT study). Common aims of these efforts were the illumination of factors associated with quality of care, as well as the development of methods to predict favorable outcomes.

  • Methods
  • Methods

    Methods:

    We use all methods of health services research comprising surveys, prospective and retrospective observational study design, complex methods on causal inference in big data, machine learning methods, risk modelling, weighting and matching, registry-based research, routinely collected data from electronic health records and administrative data.

  • Publications:
    (complete list: christianbehrendt.net )

    Rodionov RN, Peters F, Marschall U, L'Hoest H, Jarzebska N, Behrendt CA. Initiation of SGLT2 Inhibitors and the Risk of Lower Extremity Minor and Major Amputation in Patients with Type 2 Diabetes and Peripheral Arterial Disease: A Health Claims Data Analysis. Eur J Vasc Endovasc Surg. 2021;In Press. https://doi.org/10.1016/j.ejvs.2021.09.031

    Behrendt CA, Panuccio G, Kuchenbecker J, Rohlffs F, Heidemann F, Debus ES, Spanos K, Kölbel T. How Does Female Sex Affect Complex Endovascular Aortic Repair? A Single Centre Cohort Study. Eur J Vasc Endovasc Surg. 2021;In Press. https://doi.org/10.1016/j.ejvs.2021.08.034

    Acar L, Peters F, Marschall U, L'Hoest H, Twine C, Behrendt CA. Increased incidence and mortality of pulmonary embolism in patients subsequently diagnosed with COVID-19: An analysis of health insurance claims data. Eur J Vasc Endovasc Surg. 2021;In Press. https://doi.org/10.1016/j.ejvs.2021.08.027

    Behrendt CA, Sedrakyan A, Katsanos K, Nordanstig J, Kuchenbecker J, Kreutzburg T, Secemsky EA, Debus ES, Marschall U, Peters F. Sex Disparities in Long-Term Mortality after Paclitaxel Exposure in Patients with Peripheral Artery Disease: A Nationwide Claims-Based Cohort Study. J Clin Med. 2021;10:2978. https://doi.org/10.3390/jcm10132978

    Kotov A, Peters F, Debus ES, Zeller T, Heider P, Stavroulakis K, Remig J, Gussmann A, Hoffmann J, Friedrich O, Nolte T, Behrendt CA. The prospective GermanVasc cohort study. VASA. 2021;In Press. https://doi.org/10.1024/0301-1526/a000966

    Behrendt CA, Seiffert M, Gerloff C, L'Hoest H, Acar L, Thomalla G. How does SARS-CoV-2 infection affect survival among patients with cardiovascular emergencies? A cohort study from a German insurance claims database. Eur J Vasc Endovasc Surg. 2021;In Press. https://doi.org/10.1016/j.ejvs.2021.03.006

    Heidemann F, Kuchenbecker J, Peters F, Kotov A, Marschall U, L'Hoest H, Acar L, Ramkumar N, Goodney P, Debus ES, Rother U, Behrendt CA. A health insurance claims analysis on the impact of female sex on long-term outcomes after peripheral endovascular interventions for symptomatic peripheral arterial occlusive disease. J Vasc Surg. 2021;In Press. https://doi.org/10.1016/j.jvs.2021.01.066

    Behrendt CA, Kreutzburg T, Kuchenbecker J, Panuccio G, Dankhoff M, Spanos K, Kouvelos G, Debus ES, Peters F, Kölbel T. Female Sex and Outcomes after Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm: A Propensity Score Matched Cohort Analysis. J Clin Med. 2021;10:162. https://doi.org/10.3390/jcm10010162

    Peters F, Kuchenbecker J, Kreutzburg T, Marschall U, Debus ES, Behrendt CA. Long‐Term Effectiveness and Safety of Initiating Statin Therapy After Index Revascularization In Patients With Peripheral Arterial Occlusive Disease. J Am Heart Assoc. 2020;9:e018338. https://doi.org/10.1161/JAHA.120.018338

    Behrendt CA, Sigvant B, Kuchenbecker J, Grima MJ, Schermerhorn M, Thomson IA, Altreuther M, Setacci C, Svetlikov A, Laxdal EH, Goncalves FB, Secemsky EA, Debus ES, Cassar K, Beiles B, Beck AW, Mani K, Bertges D. Editor´s Choice - International Variations and Gender Disparities in the Treatment of Peripheral Arterial Occlusive Disease – A report from VASCUNET and the International Consortium of Vascular Registries. Eur J Vasc Endovasc Surg. 2020;60:873-880. https://doi.org/10.1016/j.ejvs.2020.08.027

    Kreutzburg T, Peters F, Kuchenbecker J, Marschall U, Lee R, Kriston L, Debus ES, Behrendt CA. Editor´s Choice - The GermanVasc score: A pragmatic risk score predicts five-year amputation-free survival in patients with peripheral arterial occlusive disease. Eur J Vasc Endovasc Surg. 2021;61:248-256. https://doi.org/10.1016/j.ejvs.2020.11.013

    Kotov A, Heidemann F, Kuchenbecker J, Peters F, Marschall U, Acar L, Debus ES, L'Hoest H, Behrendt CA. Sex Disparities in Long-Term Outcomes after Open Surgery for Chronic Limb-Threatening Ischaemia – A Propensity Score Matched Analysis of Health Insurance Claims. Eur J Vasc Endovasc Surg. 2021;61:423-429. https://doi.org/10.1016/j.ejvs.2020.11.006

    Seiffert M, Brunner FJ, Remmel M, Thomalla G, Marschall U, L'Hoest H, Acar L, Debus ES, Blankenberg S, Gerloff C, Behrendt CA. Temporal trends in the presentation of cardiovascular and cerebrovascular emergencies during the COVID-19 pandemic in Germany – An analysis of health insurance claims. Clin Res Cardiol. 2020;109:1540-1548. https://doi.org/10.1007/s00392-020-01723-9

    Kaschwich M, Peters F, Hischke S, Rieß HC, Gansel M, Marschall U, L'Hoest H, Heidemann F, Debus ES, Acar L, Kreutzburg T, Behrendt CA. Long-term incidence of cancer after index treatment for symptomatic peripheral arterial occlusive disease – A health insurance claims data analysis. VASA. 2020;49:493-499. https://doi.org/10.1024/0301-1526/a000901

    Peters F, Kreutzburg T, Rieß HC, Heidemann F, Marschall U, L'Hoest H, Debus ES, Sedrakyan A, Behrendt CA. Editor´s Choice - Optimal pharmacological treatment of symptomatic peripheral arterial occlusive disease and evidence of female patient disadvantage: An analysis of health insurance claims data. Eur J Vasc Endovasc Surg. 2020;60:421-429. https://doi.org/10.1016/j.ejvs.2020.05.001

    Heidemann F, Peters F, Kuchenbecker J, Kreutzburg T, Sedrakyan A, Marschall U, L'Hoest H, Debus ES, Behrendt CA. Long-term outcomes after revascularizations below the knee with paclitaxel-coated devices – a propensity score matched cohort analysis. Eur J Vasc Endovasc Surg. 2020;60:549-558. https://doi.org/10.1016/j.ejvs.2020.06.033

    Kreutzburg T, Peters F, Rieß HC, Hischke S, Marschall U, Kriston L, L´Hoest H, Sedrakyan A, Debus ES, Behrendt CA. Editor´s Choice - Comorbidity Patterns among Patients with Peripheral Arterial Occlusive Disease in Germany – A Trend Analysis of Health Insurance Claims Data. Eur J Vasc Endovasc Surg. 2020;59:59-66. https://doi.org/10.1016/j.ejvs.2019.08.006

    Behrendt CA, Debus ES, Schwaneberg T, Rieß HC, Dankhoff M, Makaloski V, Sedrakyan A, Kölbel T. Predictors of Bleeding or Anaemia requiring Transfusions in Complex Endovascular Aortic Repair and its Impact on Outcomes in Health Insurance Claims. J Vasc Surg. 2020;71:382-389. https://doi.org/10.1016/j.jvs.2019.02.059

    Heidemann F, Kölbel T, Kuchenbecker J, Schwaneberg T, Debus ES, Larena-Avellaneda A, Dankhoff M, Behrendt CA. Incidence, Predictors, and Outcomes of Spinal Cord Ischemia in Elective Complex Endovascular Aortic Repair – An Analysis of Health Insurance Claims. J Vasc Surg. 2020;72:837-848. https://doi.org/10.1016/j.jvs.2019.10.095

    Hischke S, Rieß HC, Bublitz MK, Kriston L, Schwaneberg T, Härter M, Bertges D, Debus ES, Behrendt CA. Quality Indicators in Peripheral Arterial Occlusive Disease Treatment: A Systematic Review. Eur J Vasc Endovasc Surg. 2019;58:15-22. https://doi.org/10.1016/j.ejvs.2019.06.029

    Behrendt CA, Björck M, Schwaneberg T, Debus ES, Cronenwett J, Sigvant B. Editor's Choice – Recommendations for Registry Data Collection for Revascularisations of Acute Limb Ischaemia: A Delphi Consensus from the International Consortium of Vascular Registries. Eur J Vasc Endovasc Surg. 2019;57:816-821. https://doi.org/10.1016/j.ejvs.2019.02.023

    Behrendt CA, Bischoff MS, Schwaneberg T, Hohnhold R, Diener H, Debus ES, Rieß HC. Population-based analysis of gender disparities in 23,715 percutaneous endovascular revascularisations in the metropolitan area of Hamburg. Eur J Vasc Endovasc Surg. 2019;57:658-665. https://doi.org/10.1016/j.ejvs.2018.10.021

    Rieß HC, Debus ES, Schwaneberg T, Sedrakyan A, Kölbel T, Tsilimparis N, Larena-Avellaneda A, Behrendt CA. Gender disparities in fenestrated and branched endovascular aortic repair. Eur J Cardiothorac Surg. 2019;55:338-344. https://doi.org/10.1093/ejcts/ezy249

    Behrendt CA, Rieß HC, Schwaneberg T, Larena-Avellaneda A, Kölbel T, Tsilimparis N, Spanos K, Debus ES, Sedrakyan A. Incidence, predictors and outcomes of colonic ischaemia in abdominal aortic aneurysm repairs. Eur J Vasc Endovasc Surg. 2018;56:507-513. https://doi.org/10.1016/j.ejvs.2018.06.010

    Behrendt CA, Sedrakyan A, Schwaneberg T, Kölbel T, Spanos K, Debus ES, Rieß HC. Impact of weekend treatment on short-term and long-term survival following urgent repair of ruptured aortic aneurysms in Germany. J Vasc Surg. 2018;69:792-799.e2. https://doi.org/10.1016/j.jvs.2018.05.248

    Behrendt CA, Bertges D, Eldrup N, Beck AW, Mani K, Venermo M, Szeberin Z, Menyhei G, Thomson I, Heller G, Wigger P, Danielsson G, Galzerano G, Lopez C, Altreuther M, Sigvant B, Rieß HC, Sedrakyan A, Beiles B, Björck M, Boyle JR, Debus ES, Cronenwett J. International Consortium of Vascular Registries Consensus Recommendations for Peripheral Revascularization Registry Data Collection. Eur J Vasc Endovasc Surg. 2018;56:217-237. https://doi.org/10.1016/j.ejvs.2018.04.006

    Behrendt CA, Sedrakyan A, Rieß HC, Heidemann F, Kölbel T, Debus ES. Short-term and long-term results of endovascular and open repair of abdominal aortic aneurysms in Germany.J Vasc Surg. 2017;66:1704-1711.e3. https://doi.org/10.1016/j.jvs.2017.04.040

  • Recent Funding:

    • PSI study (B.Braun, 13.000 Euro, PI: C.-A. Behrendt)
    • CORONA study (Deutscher Stifterverband, 751.000 Euro, 2015-2021, Co-PI: C.-A. Behrendt)
    • IDOMENEO study (Innovationsfond des G-BA, 2017-2021, 3.561.000 Euro, PI: C.-A. Behrendt)
    • RABATT study (Innovationsfond des G-BA, 1.528.000 Euro, 2019-2023, PI: C.-A. Behrendt)

Research Team


Statisticians and Epidemiologists:

M.Sc. Frederik Peters, PhD
(Research Group GermanVasc, Christoph-Probst-Weg 1, 20251 Hamburg)

M.Sc. Thea Kreutzburg
(Research Group GermanVasc, Christoph-Probst-Weg 1, 20251 Hamburg)

M.Sc. Jenny Kuchenbecker
(Research Group GermanVasc, Christoph-Probst-Weg 1, 20251 Hamburg);


Study Nurses:

Ms. Sarah Schmidt
(Research Group GermanVasc, Christoph-Probst-Weg 1, 20251 Hamburg)

Ms. Breda Geertz
(Research Group GermanVasc, Christoph-Probst-Weg 1, 20251 Hamburg)

Ms. Nicol Rona
(Research Group GermanVasc, Christoph-Probst-Weg 1, 20251 Hamburg)