Ausgewählte Publikationen

Wang S, Brunne B, Zhao S, Chai X, Li J, Lau J, Failla AV, Zobiak B, Sibbe M, Westbrook GL, Lutz D, Frotscher M (2018) Trajectory analysis unveils Reelin's role in the directed migration of granule cells in the dentate gyrus. J Neurosci 38:137-148

Haumann I, Junghans D, Anstötz M, Frotscher M (2017) Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function in the mammalian retina. PloS ONE 12(2):e0172967.

Lutz D, Sharaf A, Drexler D, Kataria H, Wolters-Eisfeld G, Brunne B, Kleene R, Loers G, Frotscher M, Schachner M (2017) Proteolytic cleavage of transmembrane cell adhesion molecule L1 by extracellular matrix molecule Reelin is important for mouse brain development. Sci Rep 7:15268.

Scharkowski F, Frotscher M, Lutz D, Korte M, Michaelsen-Preusse K (2017) Altered connectivity and synapse maturation of the hippocampal mossy fiber pathway in a mouse model of the fragile X syndrome. Cereb Cortex doi: 10.1093/cercor/bhw408. (Epub ahead of print)

Segal-Salto M, Hansson K, Sapir T, Levy T, Kaplan A, Schweizer M, Frotscher M, James P, Reiner O (2017) Proteomics insights into Infantile Neuronal Ceroid Lipofuscinosis (CLN1) point to the involvement of cilia pathology in the disease. Hum Mol Genet 26:1678.

Chai X, Zhao S, Fan L, Zhang W, Lu X, Shao H, Wang S, Song L, Failla AV, Zobiak B, Mannherz HG, Frotscher M (2016) Reelin and cofilin cooperate during the migration of cortical neurons: a quantitative morphological analysis. Development 143:1029-1040.

Ding Y, Huang L, Xian X, Yuhanna IS, Wasser CR, Frotscher M, Mineo C, Shaul PW, Herz J (2016) Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation. Sci Signal 9:ra29.

Guzman SJ, Schlögl A, Frotscher M, Jonas P (2016) Synaptic mechanisms of pattern completion in the hippocampal CA3 network. Science 353:117-1123.

Chai X, Fan L, Shao H, Lu X, Zhang W, Li J, Wang J, Chen S, Frotscher M, Zhao S (2015) Reelin induces branching of neurons and radial glial cells during corticogenesis. Cereb Cortex 25:3640-3653.

Decker JM, Krüger L, Sydow A, Zhao S, Frotscher M, Mandelkow E, Mandelkow EM (2015) Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation. Acta Neuropathol Commun 3:23. Doi: 10.1186/s40478-015-0193-3.

Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J (2015) Reelin protects against amyloid β toxicity in vivo. Sci Signal 8:ra67.

Singec I, Knoth R, Vida I, Frotscher M (2015) The rostral migratory stream generates hippocampal CA1 pyramidal-like neurons in a novel organotypic slice co-culture model. Biol Open 4:1222-8

Chai X, Münzner G, Zhao S, Tinnes S, Kowalski J, Häussler U, Young C, Haas CA, Frotscher M (2014) Epilepsy-induced motility of differentiated neurons. Cereb Cortex 24: 2130-2140.

Korkotian E, Frotscher M, Segal M (2014) Synaptopodin regulates spine plasticity: mediation by Calcium stores. J Neurosci 34:11641-11651.

Studer D, Zhao S, Chai X, Jonas P, Graber W, Nestel S, Frotscher M (2014) Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue. Nature Protoc 9:1480-1495.

Bouché E, Romero-Ortega MI, Henkemeyer M, Catchpole T, Leemhuis J, Frotscher M, May P, Herz J, Bock HH (2013) Reelin induces EphB activation. Cell Res 23:473-490.

Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu M, Deogracias R, Gundelfinger ED, Kojima M, Nestel S, Frotscher M, Barde Y-A (2012) BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons. J Cell Biol 196:775-788.

Sapir T, Frotscher M, Levy T, Mandelkow E-M, Reiner O (2012) Tau’s role in the developing brain: implications for intellectual disability. Hum Mol Genet 21:1681-1692.

Bähner F, Weiss EK, Birke G, Maier N, Schmitz D, Rudolph U, Frotscher M, Traub RD, Both M, Draguhn A (2011) Cellular correlate of assembly formation in oscillating hippocampal networks in vitro. Proc Natl Acad Sci USA 108:E607-E616.

Hellwig S, Hack I, Kowalski J, Brunne B, Jarowyj J, Unger A, Bock HH, Junghans D, Frotscher M (2011) Role for Reelin in neurotransmitter release. J Neurosci 31:2352-2360.

Frotscher M (2010) Role for Reelin in stabilizing cortical architecture. Trends Neurosci 33:407-414.

Brill MS, Ninkovic J, Winpenny E, Hodge RD, Ozen I, Yang R, Lepier A, Gascón S, Erdelyi F, Szabo G, Parras C, Guillemot F, Frotscher M, Berninger B, Hevner RF, Raineteau O, Götz M (2009) Adult generation of glutamatergic olfactory bulb interneurons. Nat Neurosci 12:1524-1533.

Sibbe M, Förster E, Basak O, Taylor V, Frotscher M (2009) Reelin and Notch1 cooperate in the development of the dentate gyrus. J Neurosci 29:8578-8585.

Chai X, Förster E, Zhao S, Bock HH, Frotscher M (2009) Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J Neurosci 29:288-299.

Bucurenciu I, Kulik A, Schwaller B, Frotscher M, Jonas P (2008) Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse. Neuron 57:536-545.

Hack I, Hellwig S, Junghans D, Brunne B, Bock HH, Zhao S, Frotscher M (2007) Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development 134:3883-3891.

Singec I, Knoth R, Meyer RP, Maciaczyk J, Volk B, Nikkhah G, Frotscher M, Snyder EY (2006) Defining the actual sensitivity and specificity of the cytosphere assay in stem cell biology. Nature Meth 3:801-806.

Förster E, Zhao S, Frotscher M (2006) Laminating the hippocampus. Nature Rev Neurosci 7:259-267.

Knöll B, Kretz O, Fiedler C, Alberti S, Schütz G, Frotscher M, Nordheim A (2006) Serum response factor controls neuronal circuit assembly in the hippocampus. Nature Neurosci 9:195-204.

Beffert U, Weeber EJ, Durudas A, Qiu S, Masiulis I, Sweatt JD, Li W-P, Adelmann G, Frotscher M, Hammer RE, Herz J (2005) Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron 47:567-579.

Alberti S, Krause SM, Kretz O, Philippar U, Lemberger T, Casanova E, Wiebel FF, Schwarz H, Frotscher M, Schütz G, Nordheim A (2005) Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc Natl Acad Sci USA 102:6148-6153.

Zhao S, Chai X, Förster E, Frotscher M (2004) Reelin is a positional signal for the lamination of dentate granule cells. Development 131:5117-5125.

Grunwald IC, Korte M, Adelmann G, Plueck A, Kullander K, Adams RH, Frotscher M, Bonhoeffer T, Klein R (2004) Hippocampal plasticity requires postsynaptic ephrinBs. Nature Neurosci 7:33-40.

Deller T, Korte M, Chabanis S, Drakew A, Schwegler H, Stefani GG, Zuniga A, Schwarz K, Bonhoeffer T, Zeller R, Frotscher M, Mundel P (2003) Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci USA 100:10494-10499.

Zhao S, Förster E, Chai X, Frotscher M (2003) Different signals control laminar specificity of commissural and entorhinal fibers to the dentate gyrus. J Neurosci 23:7351-7357.

Bartos M, Vida I, Frotscher M, Meyer A, Monyer H, Geiger JRP, Jonas P (2002) Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. Proc Natl Acad Sci (USA) 99:13222-13227.

Förster E, Tielsch A, Saum B, Weiss KH, Johanssen C, Graus-Porta D, Müller U, Frotscher M (2002) Reelin, Disabled 1, and beta1 integrins are required for the formation of the radial glial scaffold in the hippocampus. Proc Natl Acad Sci (USA) 99:13178-13183.

Vida I, Frotscher M (2000) A hippocampal interneuron associated with the mossy fiber system. Proc Natl Acad Sci USA 97:1275-1280.

Frotscher M (1998) Cajal-Retzius cells, Reelin, and the formation of layers. Curr Opin Neurobiol 8:570-575.

Geiger JRP, Lübke J, Roth A, Frotscher M, Jonas P (1997) Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron 18:1009-1023.

Frotscher M, Heimrich B, Deller T (1997) Sprouting in the hippocampus is layer-specific. Trends Neurosci 20:218-223.

Del Río JA, Heimrich B, Borrell V, Förster E, Drakew A, Alcántara S, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Derer P, Frotscher M, Soriano E* (1997) A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature 385:70-74.
*The last two authors have equally contributed to this study.

Markram H, Lübke J, Frotscher M, Sakmann B (1997) Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275:213-215.

Frotscher M, Heimrich B (1993) Formation of layer-specific fiber projections to the hippocampus in vitro. Proc Natl Acad Sci USA 90:10400-10403.

Nitsch R, Frotscher M (1992) Reduction of posttraumatic transneuronal "early gene" activation and dendritic atrophy by the N-methyl-D-aspartate receptor antagonist MK-801. Proc Natl Acad Sci USA 89:5197-5200.

Publikationen Michael Frotscher