Christine Gräfin zu Eulenburg
  • Wissenschaftlerin


W34, EG, Raumnummer 9b
Deutsch (Muttersprache)




Improved risk stratification by circulating tumor cell counts in pancreatic cancer
Effenberger K, Schroeder C, Hanssen A, Wolter S, Eulenburg C, Tachezy M, Gebauer F, Izbicki J, Pantel K, Bockhorn M
CLIN CANCER RES. 2018;24(12):2844-2850.

Associations between adjuvant radiotherapy and different causes of death in a German breast cancer cohort
Obi N, Eulenburg C, Seibold P, Eilber U, Thöne K, Behrens S, Chang-Claude J, Flesch-Janys D
BREAST. 2018;38:75-80.

A weighted combined effect measure for the analysis of a composite time-to-first-event endpoint with components of different clinical relevance
Rauch G, Kunzmann K, Kieser M, Wegscheider K, König J, Eulenburg C
STAT MED. 2018;37(5):749-767.


The role of transvaginal ultrasonography for detecting ovarian cancer in an asymptomatic screening population: a systematic review
Buhling K, Lezon S, Eulenburg C, Schmalfeldt B
ARCH GYNECOL OBSTET. 2017;295(5):1259-1268.

Baseline use of antiarrhythmics in patients given adaptive servoventilation: SERVE-HF-Authors' reply
Eulenburg C, Wegscheider K, Woehrle H, Cowie M
LANCET RESP MED. 2017;5(1):e5.

A lateral cephalometry study of patients with neurofibromatosis type 1
Friedrich R, Lehmann J, Rother J, Christ G, Zu Eulenburg C, Scheuer H, Scheuer H
J CRANIO MAXILL SURG. 2017;45(6):809-820.

Acute versus Chronic Myocardial Infarction: Diagnostic Accuracy of Quantitative Native T1 and T2 Mapping versus Assessment of Edema on Standard T2-weighted Cardiovascular MR Images for Differentiation
Tahir E, Sinn M, Bohnen S, Avanesov M, Säring D, Stehning C, Schnackenburg B, Eulenburg C, Wien J, Radunski U, Blankenberg S, Adam G, Higgins C, Saeed M, Muellerleile K, Lund G
RADIOLOGY. 2017;285(1):83-91.


Duodenal Electric Stimulation: Results of a First-in-Man Study
Aberle J, Busch C, Veigel J, Duprée A, Roesch T, Zu Eulenburg C, Paschen B, Scholz B, Wolter S, Sauer N, Ludwig K, Izbicki J, Mann O
OBES SURG. 2016;26(2):369-75.

A Comprehensive Multistate Model Analyzing Associations of Various Risk Factors With the Course of Breast Cancer in a Population-Based Cohort of Breast Cancer Cases
Eulenburg C, Schroeder J, Obi N, Heinz J, Seibold P, Rudolph A, Chang-Claude J, Flesch-Janys D
AM J EPIDEMIOL. 2016;183(4):325-334.

Mechanisms underlying increased mortality risk in patients with heart failure and reduced ejection fraction randomly assigned to adaptive servoventilation in the SERVE-HF study results of a secondary multistate modelling analysis
Eulenburg C, Wegscheider K, Woehrle H, Angermann C, d'Ortho M, Erdmann E, Levy P, Simonds A, Somers V, Zannad F, Teschler H, Cowie M
LANCET RESP MED. 2016;4(11):873-881.

Einfluss der Familienanamnese auf das Brustkrebsrisiko postmenopausaler Brustkrebspatientinnen – Ergebnisse aus der MARIE-Studie
Krauß K, zu Eulenburg C, Thoene K, Rudolph A, Chang-Claude J, Witzel I
Senologie. 2016 [Epub ahead of print];13(02):.

Radiological Patterns of Brain Metastases in Breast Cancer Patients: A Subproject of the German Brain Metastases in Breast Cancer (BMBC) Registry
Laakmann E, Witzel I, Scriba V, Grzyska U, Zu Eulenburg C, Burchardi N, Hesse T, Würschmidt F, Fehm T, Möbus V, von Minckwitz G, Loibl S, Park-Simon T, Mueller V
INT J MOL SCI. 2016;17(10):E1615.

Effect of Positive Airway Pressure on Cardiovascular Outcomes in Coronary Artery Disease Patients with NonSleepy Obstructive Sleep Apnea:The RICCADSA Randomized Controlled Trial
Peker Y, Glantz H, Eulenburg C, Wegscheider K, Herlitz J, Thunström E
AM J RESPIR CRIT CARE MED. 2016;194(5):613-620.

Patterns of distant metastases in vulvar cancer
Prieske K, Haeringer N, Grimm D, Trillsch F, Eulenburg C, Burandt E, Schmalfeldt B, Mahner S, Mueller V, Woelber L
GYNECOL ONCOL. 2016;142(3):427-34.

Time-dependent postural control adaptations following a neuromuscular warm-up in female handball players: a randomized controlled trial
Steib S, Zahn P, Zu Eulenburg C, Pfeifer K, Zech A
BMC Sports Sci Med Rehabil. 2016;8:33.

E-Cadherin fragments as potential mediators for peritoneal metastasis in advanced epithelial ovarian cancer
Trillsch F, Kuerti S, zu Eulenburg C, Burandt E, Woelber L, Prieske K, Eylmann K, Oliveira-Ferrer L, Milde-Langosch K, Mahner S
BRIT J CANCER. 2016;114(2):213-220.

Linear accuracy and reliability of volume data sets acquired by two CBCT-devices and an MSCT using virtual models: A comparative in-vitro study
Wikner J, Hanken H, zu Eulenburg C, Heiland M, Gröbe A, Assaf A, Riecke B, Friedrich R
ACTA ODONTOL SCAND. 2016;74(1):51-9.

The Risk of Contralateral Non-sentinel Metastasis in Patients with Primary Vulvar Cancer and Unilaterally Positive Sentinel Node
Woelber L, Eulenburg C, Grimm D, Trillsch F, Bohlmann I, Burandt E, Dieckmann J, Klutmann S, Schmalfeldt B, Mahner S, Prieske K
ANN SURG ONCOL. 2016;23(8):2508-14.

Role of tumour-free margin distance for loco-regional control in vulvar cancer-a subset analysis of the Arbeitsgemeinschaft Gynäkologische Onkologie CaRE-1 multicenter study
Woelber L, Griebel L, Eulenburg C, Sehouli J, Jueckstock J, Hilpert F, de Gregorio N, Hasenburg A, Ignatov A, Hillemanns P, Fuerst S, Strauss H, Baumann K, Thiel F, Mustea A, Meier W, Harter P, Wimberger P, Hanker L, Schmalfeldt B, Canzler U, Fehm T, Luyten A, Hellriegel M, Kosse J, Heiss C, Hantschmann P, Mallmann P, Tanner B, Pfisterer J, Richter B, Neuser P, Mahner S
EUR J CANCER. 2016;69:180-188.

Propensity Scoring after Multiple Imputation in a Retrospective Study on Adjuvant Radiation Therapy in Lymph-Node Positive Vulvar Cancer
zu Eulenburg C, Suling A, Neuser P, Reuss A, Canzler U, Fehm T, Luyten A, Hellriegel M, Woelber L, Mahner S
PLOS ONE. 2016;11(11):e0165705.


Sexual Activity and Function in Patients With Gynecological Malignancies After Completed Treatment
Grimm D, Hasenburg A, zu Eulenburg C, Steinsiek L, Mayer S, Eltrop S, Prieske K, Trillsch F, Mahner S, Woelber L
INT J GYNECOL CANCER. 2015;25(6):1134-41.

Sexual activity and function after surgical treatment in patients with (pre)invasive vulvar lesions
Grimm D, zu Eulenburg C, Brummer O, Schliedermann A, Trillsch F, Prieske K, Gieseking F, Selka E, Mahner S, Woelber L
SUPPORT CARE CANCER. 2015;24(1):419-428.

A Systematic Model Specification Procedure for an Illness-Death Model without Recovery
zu Eulenburg C, Mahner S, Woelber L, Wegscheider K
PLOS ONE. 2015;10(4):Art. e0123489.

Agreements and disagreements in exercise therapy prescriptions after hip replacement among rehabilitation professionals: a multicenter survey
zu Eulenburg C, Rahlf A, Kutasow A, Zech A


The use of complementary and alternative medicine by women transitioning through menopause in Germany: results of a survey of women aged 45-60 years
Buhling K, Daniels B, von Studnitz F, zu Eulenburg C, Mueck A
COMPLEMENT THER MED. 2014;22(1):94-98.

Contraceptive counselling and self-prescription of contraceptives of German gynaecologists: results of a nationwide survey
Buhling K, Klovekorn L, Daniels B, Studnitz F, zu Eulenburg C, Mueck A
EUR J CONTRACEP REPR. 2014;19(6):448-456.

Restoration of hip architecture with bipolar hemiarthroplasty in the elderly: does it affect early functional outcome?
Hartel M, Arndt M, Eulenburg C, Petersen J, Rueger J, Hoffmann M
ARCH ORTHOP TRAUM SU. 2014;134(1):31-38.

Long-term follow-up and quality of life in patients with intracranial germinoma
Martens T, Rotermund R, Zu Eulenburg C, Westphal M, Flitsch J
NEUROSURG REV. 2014;37(3):445-451.

Prognostic relevance of glycosylation-associated genes in breast cancer
Milde-Langosch K, Karn T, Schmidt M, Zu Eulenburg C, Oliveira Ferrer L, Wirtz R, Schumacher U, Witzel I, Schütze D, Müller V
BREAST CANCER RES TR. 2014;145(2):295-305.

Time course and dimensions of postural control changes following neuromuscular training in youth field hockey athletes
Zech A, Klahn P, Hoeft J, zu Eulenburg C, Steib S
EUR J APPL PHYSIOL. 2014;114(2):395-403.


Attitude of German women towards hormone therapy: results of a lay survey.
Bühling K, Daniels B, von Studnitz F, zu Eulenburg C, Mueck A
GYNECOL ENDOCRINOL. 2013;29(5):460-464.

Analysis of orbital plain radiographs for orbital deformities in neurofibromatosis type 1 patients, with special reference to alterations of the orbital rim as indicators of adjacent plexiform neurofibroma
Friedrich R, Rother J, Christ G, Lehmann M, zu Eulenburg C, Giese M, Scheuer H
ANTICANCER RES. 2013;33(3):1081-90.

Individually optimized hemodynamic therapy reduces complications and length of stay in the intensive care unit: a prospective, randomized controlled trial
Goepfert M, Richter H, Zu Eulenburg C, Grützmacher J, Rafflenbeul E, Roeher K, von Sandersleben A, Diedrichs S, Reichenspurner H, Goetz A, Reuter D
ANESTHESIOLOGY. 2013;119(4):824-36.

Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer
Henningsen M, zu Eulenburg C, Kolarova T, Qi J, Manivong K, Chalukya M, Dering J, Anderson L, Ginther C, Meuter A, Winterhoff B, Jones S, Velculescu V, Venkatesan N, Rong H, Dandekar S, Udar N, Jänicke F, Los G, Slamon D, Konecny G
MOL CANCER THER. 2013;12(6):1002-15.

Differentiating macrophage activation syndrome in systemic juvenile idiopathic arthritis from other forms of hemophagocytic lymphohistiocytosis
Lehmberg K, Pink I, zu Eulenburg C, Beutel K, Maul-Pavicic A, Janka-Schaub G
J PEDIATR-US. 2013;162(6):1245-51.

Prognostic impact of the time interval between surgery and chemotherapy in advanced ovarian cancer: analysis of prospective randomised phase III trials.
Mahner S, zu Eulenburg C, Staehle A, Wegscheider K, Reuss A, Pujade-Lauraine E, Harter P, Ray-Coquard I, Pfisterer J, du Bois A
EUR J CANCER. 2013;49(1):142-149.

Platelet-derived growth factor receptor beta serum concentrations during first-line therapy in ovarian cancer
Mathey S, Graeser M, Zu Eulenburg C, Woelber L, Trillsch F, Jänicke F, Müller V, Milde-Langosch K, Mahner S
ONCOLOGY. 2013;85(2):69-77.

Increased osteoblast and osteoclast indices in individuals with systemic mastocytosis
Seitz S, Barvencik F, Koehne T, Priemel M, Pogoda P, Semler J, Minne H, Pfeiffer M, Zustin J, Püschel K, zu Eulenburg C, Schinke T, Amling M
OSTEOPOROSIS INT. 2013;24(8):2325-34.

Impaired bone mineralization accompanied by low vitamin D and secondary hyperparathyroidism in patients with femoral neck fracture.
Seitz S, Koehne T, Ries C, Novo De Oliveira A, Barvencik F, Busse B, zu Eulenburg C, Schinke T, Püschel K, Rueger J, Amling M, Pogoda P
OSTEOPOROSIS INT. 2013;24(2):641-649.

Treatment reality in elderly patients with advanced ovarian cancer: a prospective analysis of the OVCAD consortium
Trillsch F, Woelber L, zu Eulenburg C, Braicu I, Lambrechts S, Chekerov R, van Nieuwenhuysen E, Speiser P, Zeimet A, Castillo-Tong D, Concin N, Zeillinger R, Vergote I, Mahner S, Sehouli J
J OVARIAN RES. 2013;6(1):42.

The value of complementary and alternative medicine in the treatment of climacteric symptoms: results of a survey among German gynecologists
von Studnitz F, zu Eulenburg C, Mueck A, Buhling K
COMPLEMENT THER MED. 2013;21(5):492-5.

Progression and Death as Competing Risks in Ovarian Cancer
zu Eulenburg C, Mahner S, Wölber L, Wegscheider K
Int J Stat Med Res. 2013.


Effekte einer multimodalen Intervention zur Primärprävention kardiovaskulärer Krankheiten auf Depressivität, Angst und Typ-D-Muster: Erste Ergebnisse der randomisierten, kontrollierten PräFord-Studie
Albus C, Bjarnson-Wehrens B, Gysan D, Herold G, Schneider C, zu Eulenburg C, Predel H
HERZ. 2012;37(1):59-62.

[The effects of multimodal intervention for the primary prevention of cardiovascular diseases on depression, anxiety, and Type-D pattern: initial results of the randomized controlled PreFord trial].
Albus C, Bjarnson-Wehrens B, Gysan D, Herold G, Schneider C, Zu Eulenburg C, Predel H, PräFord-Studiengruppe [
HERZ. 2012;37(1):59-62.

Diagnostic performance of whole-body MRI for the detection of persistent or relapsing disease in multiple myeloma after stem cell transplantation.
Bannas P, Hentschel H, Bley T, Treszl A, Zu Eulenburg C, Derlin T, Yamamura J, Adam G, Stübig T, Kröger N, Weber C
EUR RADIOL. 2012;22(9):2007-2012.

Use of hormone therapy by female gynecologists and female partners of male gynecologists in Germany 8 years after the Women's Health Initiative study: results of a survey.
Bühling K, Studnitz v, Friederike S, Zu Eulenburg C, Eulenburg C, Mueck A
MENOPAUSE. 2012;19(10):1088-1091.

Attitude of German gynecologists towards prescribing HRT before and after the WHI study.
Bühling K, von Studnitz F, Jantke A, Zu Eulenburg C, Mueck A
CLIMACTERIC. 2012;15(4):326-331.

Prognostic value of perioperative near-infrared spectroscopy during neonatal and infant congenital heart surgery for adverse in-hospital clinical events.
Dodge-Khatami J, Gottschalk U, Zu Eulenburg C, Wendt U, Schnegg C, Rebel M, Reichenspurner H, Dodge-Khatami A
World J Ped Congen Heart Surg. 2012;3(2):221-228.

Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood--a meta-analysis.
Doege K, Grajecki D, Zyriax B, Detinkina E, Zu Eulenburg C, Bühling K
BRIT J NUTR. 2012;107(1):1-6.

Comparison of values in critically ill patients for global end-diastolic volume and extravascular lung water measured by transcardiopulmonary thermodilution: a meta-analysis of the literature.
Eichhorn V, Göpfert M, Zu Eulenburg C, Malbrain M, Reuter D
Med Intensiva. 2012;36(7):467-474.

Disseminated tumor cells in pancreatic cancer-an independent prognosticator of disease progression and survival.
Harms-Effenberger K, Schröder C, Zu Eulenburg C, Reeh M, Tachezy M, Riethdorf S, Vashist Y, Izbicki J, Pantel K, Bockhorn M
INT J CANCER. 2012;131(4):475-483.

Impact of the NK cell receptor LIR-1 (ILT-2/CD85j/LILRB1) on cytotoxicity against multiple myeloma.
Heidenreich S, Zu Eulenburg C, Hildebrandt Y, Stübig T, Sierich H, Badbaran A, Eiermann T, Binder T, Kröger N
Clin Dev Immunol. 2012;2012:652130.

Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review
Laakmann E, Grajecki D, Doege K, zu Eulenburg C, Buhling K
GYNECOL ENDOCRINOL. 2012;28(9):703-9.

Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review.
Laakmann E, Grajecki D, Doege K, Zu Eulenburg C, Bühling K
GYNECOL ENDOCRINOL. 2012;28(9):703-709.

Predictive value of HER2 serum levels in patients treated with lapatinib or trastuzumab -- a translational project in the neoadjuvant GeparQuinto trial.
Witzel I, Loibl S, von Minckwitz G, Eidtmann H, Fehm T, Khandan F, Schmatloch S, Hauschild M, Bischoff J, Fasching P, Mau C, Schem C, Rack B, Meinhold-Heerlein I, Liedtke C, Karn T, Huober J, Zu Eulenburg C, Issa-Nummer Y, Untch M, Müller V
BRIT J CANCER. 2012;107(6):956-960.

EGFR gene copy number increase in vulvar carcinomas is linked with poor clinical outcome.
Wölber L, Hess S, Bohlken H, Tennstedt P, Zu Eulenburg C, Simon R, Gieseking F, Jänicke F, Mahner S, Choschzick M
J CLIN PATHOL. 2012;65(2):133-139.

Prognostic role of lymph node metastases in vulvar cancer and implications for adjuvant treatment
Wölber L, Zu Eulenburg C, Choschzick M, Krüll A, Petersen C, Gieseking F, Jänicke F, Mahner S
INT J GYNECOL CANCER. 2012;22(3):503-508.


B-cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia.
Binder M, Müller F, Jackst A, Lechenne B, Pantic M, Bacher U, Zu Eulenburg C, Veelken H, Mertelsmann R, Pasqualini R, Arap W, Trepel M
CANCER-AM CANCER SOC. 2011;117(9):1891-1900.

MitraClip® therapy in patients with end-stage systolic heart failure.
Franzen O, van der Heyden J, Baldus S, Schlüter M, Schillinger W, Butter C, Hoffmann R, Corti R, Pedrazzini G, Swaans M, Neuss M, Rudolph V, Sürder D, Grünenfelder J, Zu Eulenburg C, Reichenspurner H, Meinertz T, Auricchio A
EUR J HEART FAIL. 2011;13(5):569-576.

Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression pattern.
Harms-Effenberger K, Borgen E, Zu Eulenburg C, Bartkowiak K, Grosser A, Synnestvedt M, Kaaresen R, Brandt B, Nesland J, Pantel K, Naume B
BREAST CANCER RES TR. 2011;125(3):729-738.

Serum carbonic anhydrase IX and its prognostic relevance in vulvar cancer.
Kock L, Mahner S, Choschzick M, Zu Eulenburg C, Milde-Langosch K, Schwarz J, Jänicke F, Müller V, Wölber L
INT J GYNECOL CANCER. 2011;21(1):141-148.

Antibody response after a single dose of an AS03-adjuvanted split-virion influenza A (H1N1) vaccine in heart transplant recipients.
Meyer S, Adam M, Schweiger B, Ilchmann C, Zu Eulenburg C, Sattinger E, Runte H, Schlüter M, Deuse T, Reichenspurner H, Costardt-Jäckle A
TRANSPLANTATION. 2011;91(9):1031-1035.

Prognostic and predictive relevance of CA-125 at primary surgery of ovarian cancer.
Schütze D, Wölber L, Jung S, Zu Eulenburg C, Choschzick M, Witzel I, Schwarz J, Jänicke F, Mahner S
J CANCER RES CLIN. 2011;137(7):1131-1137.

Health-related quality of life and patient-defined benefit of clobetasol 0.05% in women with chronic lichen sclerosus of the vulva.
Schwegler J, Schwarz J, Zu Eulenburg C, Blome C, Henningsen M, Mahner S, Jänicke F, Augustin M, Wölber L
DERMATOLOGY. 2011;223(2):152-160.

Pregnancy in primary sclerosing cholangitis.
Wellge B, Sterneck M, Teufel A, Rust C, Franke A, Schreiber S, Berg T, Günther R, Kreisel W, Zu Eulenburg C, Braun F, Beuers U, Galle P, Lohse A, Schramm C
GUT. 2011;60(8):1117-1121.

Prognostic value of pathological resection margin distance in squamous cell cancer of the vulva.
Wölber L, Choschzick M, Zu Eulenburg C, Hager M, Jänicke F, Gieseking F, Kock L, Henningsen M, Petersen C, Schwarz J, Mahner S
ANN SURG ONCOL. 2011;18(13):3811-3818.


Overexpression of carbonic anhydrase IX (CAIX) in vulvar cancer is associated with tumor progression and development of locoregional lymph node metastases.
Choschzick M, Wölber L, Hess S, Zu Eulenburg C, Schwarz J, Simon R, Mahner S, Jänicke F, Müller V
VIRCHOWS ARCH. 2010;456(5):483-490.

TIMP-1 and VEGF-165 serum concentration during first-line therapy of ovarian cancer patients.
Mahner S, Wölber L, Zu Eulenburg C, Schwarz J, Carney W, Jänicke F, Milde-Langosch K, Müller V
BMC CANCER. 2010;10:139.

Monitoring serum HER2 levels during neoadjuvant trastuzumab treatment within the GeparQuattro trial.
Witzel I, Loibl S, von Minckwitz G, Mundhenke C, Huober J, Hanusch C, Henschen S, Hauschild M, Lantzsch T, Tesch H, Latos K, Just M, Hilfrich J, Barinoff J, Zu Eulenburg C, Roller M, Untch M, Müller V
BREAST CANCER RES TR. 2010;123(2):437-445.

Comparison of microarray-based RNA expression with ELISA-based protein determination of HER2, uPA and PAI-1 in tumour tissue of patients with breast cancer and relation to outcome.
Witzel I, Milde-Langosch K, Wirtz R, Roth C, Henningsen M, Mahner S, Zu Eulenburg C, Jänicke F, Müller V
J CANCER RES CLIN. 2010;136(11):1709-1718.

Perioperative morbidity and outcome of secondary cytoreduction for recurrent epithelial ovarian cancer.
Wölber L, Jung S, Zu Eulenburg C, Müller V, Schwarz J, Jänicke F, Mahner S
EJSO-EUR J SURG ONC. 2010;36(6):583-588.

Serum carbonic anhydrase IX during first-line therapy of ovarian cancer.
Wölber L, Müller V, Zu Eulenburg C, Schwarz J, Carney W, Jänicke F, Milde-Langosch K, Mahner S
GYNECOL ONCOL. 2010;117(2):183-188.


Single nucleotide polymorphism in esophageal cancer related gene 1: an analysis in resected oral squamous cell carcinoma patients.
Blessmann M, Pohlenz P, Atac A, Kaifi J, Zu Eulenburg C, Kalinin V, Merkert P, Smeets R, Heiland M, Blake F, Schmelzle R, Izbicki J
INT J ORAL MAX SURG. 2009;38(7):779-784.

Prognostic Significance of CA-125 in the Management of Patients with Recurrent Epithelial Ovarian Carcinoma Selected for Secondary Cytoreduction.
Mahner S, Wölber L, Jung S, Zu Eulenburg C, Henningsen M, Schwarz J, Sehouli J, Jänicke F
ANTICANCER RES. 2009;29(7):2817-2821.

Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer.
Wölber L, Mahner S, Voelker K, Zu Eulenburg C, Gieseking F, Choschzick M, Jänicke F, Schwarz J
ANTICANCER RES. 2009;29(2):545-552.

Letzte Aktualisierung aus dem FIS: 12.07.2020 - 00:43 Uhr