2018

Bönstrup M, Schulz R, Schoen G, Cheng B, Feldheim J, Thomalla G, Gerloff C (2018). Parietofrontal network upregulation after motor stroke. Neuroimage Clin 18: 720-729

Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B, Cheripelli B, Cho TH, Fazekas F, Fiehler J, Ford I, Galinovic I, Gellissen S, Golsari A, Gregori J, Günther M, Guibernau J, Häusler KG, Hennerici M, Kemmling A, Marstrand J, Modrau B, Neeb L, Perez de la Ossa N, Puig J, Ringleb P, Roy P, Scheel E, Schonewille W, Serena J, Sunaert S, Villringer K, Wouters A, Thijs V, Ebinger M, Endres M, Fiebach JB, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Gerloff C, on behalf of the WAKE-UP investigators (2018) MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. N Engl J Med 2018 May 16. doi: 10.1056/NEJMoa1804355

Gromova KV, Muhia M, Rothammer N, Gee, CE, Thies E, Schaefer I, Kress S, Kilimann MW, Shevchuk O, Oertner TG, Kneussel M (2018) Neurobeachin and the Kinesin KIF21B are critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior. Cell Reports 23:2705–2717.

Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M (2018) Muskelin Coordinates PrP(C) Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. Neuron. 99(6):1155-1169.

Ahlbeck, J., Song, L., Chini, M., Bitzenhofer, S.H., Hanganu-Opatz, I.L. (2018) Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse. eLife, pii: e33158.

Mikhaylova M*, Bär J, van Bommel B, Schätzle P, YuanXiang PY, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C, Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR*. Caldendrin directly couples postsynaptic calcium signals to actin-remodeling in dendritic spines. Neuron 2018 Mar 7;97(5):1110-1125.e14. *shared correspondence

Scheib U, Broser M, Constantin OM, Yang S, Gao S, Mukherjee S, Stehfest K, Nagel G, Gee CE*, Hegemann P* (2018) Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain. Nature Communications 9:2046 *equal contrib. FOR 2419

Richter M., Murtaza N., Scharrenberg R., White S.H., Johanns O., Walker S., Yuen R.K., Schwanke B., Bedürftig B., Henis M., Scharf S., Kraus V., Dörk R., Hellmann J., Lindenmaier Z., Ellegood J., Hartung H., Kwan V., Sedlacik J., Fiehler J., Schweizer M., Lerch J.P., Hanganu-Opatz I.L., Morellini F., Scherer S.W., Singh K.K. and Calderon de Anda F. Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling. Molecular Psychiatry, 2018 Feb 21. doi: 10.1038/s41380-018-0025-5. PMID: 29467497

2017

Bitzenhofer, S.H., Ahlbeck J., Wolff, A., Wiegert, J.S., Gee, C.E., Oertner, T.G., Hanganu-Opatz, I.L. (2017) Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nature Comm., 8:14563.

Katrukha EA*, Mikhaylova M*, van Brakel HX, van Bergen En Henegouwen PM, Akhmanova A, Hoogenraad CC, Kapitein LC. Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots. Nat Commun. 2017 Mar 21;8:14772. * shared first authorship

Frese CK*, Mikhaylova M*, Stucchi R*, Gautier V, Liu Q, Mohammed S, Heck AJR, Altelaar AFM, Hoogenraad CC. Quantitative Map of Proteome Dynamics during Neuronal Differentiation. Cell Reports. 2017 Feb 7;18 (6): 1527-42.* shared first authorship

Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR. Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Rep. 2017 pii: e201643519.

Wietek J, Rodriguez-Rozada S, Tutas J, Tenedini F, Grimm C, Oertner TG. Soba P, Hegemann P, Wiegert JS (2017) Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep 7:14957

Wiegert JS, Mahn M, Prigge M, Prinz Y, Yizhar O (2017) Silencing neurons: tools, applications, and experimental constraints. Neuron 95:504-529

Bitzenhofer SH, Ahlbeck J, Wolff A, Wiegert JS, Gee CE, Oertner TG, Hanganu-Opatz IL (2017) Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Commun 8:14563

Zhao B., Meka D.P., Scharrenberg R., König T., Schwanke B., Kobler O., Windhorst S., Kreutz M.R., Mikhaylova M., Calderon de Anda F. Microtubules modulate F-actin dynamics during neuronal polarization. Scientific Reports, 7(2017) 9583.

2016

Schulz R, Buchholz A, Frey BM, Bönstrup M, Cheng B, Thomalla G, Hummel FC, Gerloff C (2016) Enhanced Effective Connectivity Between Primary Motor Cortex and Intraparietal Sulcus in Well-Recovered Stroke Patients. Stroke 47, 482-9

Finger H, Bönstrup M, Cheng B, Messé A, Hilgetag C, Thomalla G, Gerloff C, König P (2016) Modeling of Large-Scale Functional Brain Networks Based on Structural Connectivity from DTI: Comparison with EEG Derived Phase Coupling Networks and Evaluation of Alternative Methods along the Modeling Path. PLoS Comput Biol. 2016 Aug 9;12(8):e1005025. doi: 10.1371/journal.pcbi.1005025

Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M, Holzbaur ELF (2016) Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B. Neuron 92:857-872.

Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T (2016) Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. Neuron 92:845-856.

Muhia M, Thies E, Labonté D, Ghiretti AE, Gromova KV, Xompero F, Lappe-Siefke C, Hermans-Borgmeyer I, Kuhl D, Schweizer M, Ohana O, Schwarz JR, Holzbaur EL, Kneussel M (2016) The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory. Cell Reports 15:968-977.

Takahashi N, Oertner TG, Hegemann P, Larkum ME (2016) Active cortical dendrites modulate perception. Science 354(6319): 1587-1590

Hartung, H., Cichon, N., De Feo, V., Riemann, S., Schildt, S., Lindemann, C., Mulert, C., Gogos, J.A., Hanganu-Opatz, I.L. (2016) From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders. Cereb Cortex 2016 Sep 9.

Hartung, H., Brockmann, M.D., Pöschel, B., De Feo, V., Hanganu-Opatz, I.L. (2016) Thalamic and Entorhinal Network Activity Differently Modulates the Functional Development of Prefrontal-Hippocampal Interactions. J Neurosci 36(13): 3676-90.

Bär J, Kobler O, van Bommel B, Mikhaylova M. Periodic F-actin structures shape the neck of dendritic spines. Sci Rep. 2016 Nov 14;6:37136.

Mikhaylova M, Bera S, Kobler O, Frischknecht R, Kreutz MR. A dendritic Golgi satellite in between ERGIC and retrome. Cell Rep. 2016 Jan 12;14(2):189-99.

Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, Burguière A, Caldarelli A, Genazzani AA, Perroy J, Fagni L, Canonico PL, Kreutz MR*, Gardoni F*, Di Luca M*. Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus. Elife. 2016 5. pii: e12430. *shared correspondence 1*

Mikhaylova, M, Bera, S, Kobler, O, Frischknecht, R, Kreutz, MR (2016) A Dendritic Golgi Satellite between ERGIC and Retromer. Cell Rep 2016 14:189-99.

Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, Yuanxiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D'Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genet. 2016 12(3):e1005907.

Kwan, V., Meka, D.P., White, S., Hung, C. L., Holzapfel, N. T., Walker, S., Murtaza, N., Unda, B., Schwanke, B., Yuen, R.K.C., Habing, K., Milsom, C., Hope, K., Truant, R., Scherer, S.W., Calderon de Anda, F., Singh, K.K. DIXDC1 phosphorylation and control of dendritic morphology is impaired by rare genetic variants. Cell Reports, 7(2016) 1892-1904.

Calderon de Anda F.*, Madabhushi R., Rei D., Meng J., Gräff J., Durak O., Meletis K., Richter M., Schwanke B., Mungenast A., Tsai L.H. Cortical neurons gradually attain a post-mitotic state. Cell Research, 26(2016) 1033-1047. *Corresponding author.

2015

Bönstrup M, Schulz R, Feldheim J, Hummel FC, Gerloff C (2015) Dynamic causal modelling of EEG and fMRI to characterize network architectures in a simple motor task. Neuroimage 124, 498-508

Schulz R, Koch P, Zimerman M, Wessel M, Bönstrup M, Thomalla G, Cheng B, Gerloff C, Hummel FC (2015) Parietofrontal motor pathways and their association with motor function after stroke. Brain 138, 1949-1960.

Hausrat, TJ, Muhia, M, Gerrow, K, Thomas, P, Hirdes, W, Tsukita, S, Heisler, FF, Herich, L, Dubroqua, S, Breiden, P, Feldon, J, Schwarz, JR, Yee, BK, Smart, TG, Triller, A, Kneussel, M (2015) Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Nature Communications 6:6872.

Sieben, K., Bieler, M., Röder, B., Hanganu-Opatz, I.L. (2015) Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing. PLoS Biol 13: e1002304.

Marguet, S.L., Le-Schulte, V.T., Merseburg, A., Neu, A., Eichler, R., Jakovcevski, I., Ivanov, A., Hanganu-Opatz, I.L., Bernard, C., Morellini, F., Isbrandt, D. (2015) Treatment during a vulnerable developmental period rescues a genetic epilepsy. Nature Med 21(12):1436-44.

Bitzenhofer, S.H., Sieben, K., Siebert, K., Spehr, M., Hanganu-Opatz, I.L. (2015) Oscillatory activity in developing prefrontal networks results from theta-gamma modulated synaptic inputs. Cell Reports 11: 486-97.

Mikhaylova M, Cloin BM, Finan K, van den Berg R, Teeuw J, Kijanka MM, Sokolowski M, Katrukha EA, Maidorn M, Opazo F, Moutel S, Vantard M, Perez F, van Bergen En Henegouwen PM, Hoogenraad CC, Ewers H, Kapitein LC. Resolving bundled microtubules using anti-tubulin nanobodies. Nat Commun. 2015 Aug 11;6:7933.

Scheib U*, Stehfest K*, Gee CE*, Körschen HG, Fudim R, Oertner TG, Hegemann P (2015) The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Science Signaling 8(389):rs8. *equal contribution

Wietek J, Beltramo R, Scanziani M, Hegemann P, Oertner TG, Wiegert JS (2015). An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep 5:14807

2014

Heisler FF, Lee HK, Gromova KV, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M (2014) GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites. Proc Natl Acad Sci USA 111:5030-5035.

Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob T, Moss S, Benfenati F, Medini P, Kneussel M, Barberis A (2014) Synaptic recruitment of gephyrin regulates surface GABAA receptors dynamics for the expression of inhibitory LTP. Nature Communications 5: 3921.

Wietek J, Wiegert JS, Adeishvili N, Schneider F, Watanabe H, Tsunoda SP, Vogt A, Elstner M, Oertner TG, Hegemann P (2014) Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344(6182): 409-412

Mikhaylova M, Karpova A, Baer J, Bethge P, YuanXiang P, Chen Y, Zuschratter W, Behnisch T, Kreutz MR. Cellular distribution of the NMDA-receptor activated nucleocytoplasmic messenger Jacob in the rat brain. Brain structure and function. 2014 May;219(3):843-60.

Gee CE*, Peterlik D*, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S, Cryan JF, van der Putten H, Fendt M, Vranesic I, Glatthar R, Flor PJ. (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress and anxiety-related behavior. Journal of Biological Chemistry 289:10975-10987 *equal contribution

Wietek J*, Wiegert JS*, Adeishvili N, Schneider F, Watanabe H, Tsunoda S, Vogt A, Elstner M, Oertner TG, Hegemann P (2014) Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182):409-412, *first 2 authors equally contributing

Durak O.*, Calderon de Anda F.*, Singh K.K., Leussis M.P., Petryshen T.L. Sklar P., Tsai L.H. Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of -catenin. Molecular Psychiatry. Advance online publication, 13 May 2014; doi: 10.1038/mp.2014.42. *Equal contribution.

2013

Engel AK, Gerloff C, Hilgetag CC, Nolte G (2013) Intrinsic coupling modes: multiscale interac-tions in ongoing brain activity. Neuron 80: 867-886

Kneussel M, Wagner W (2013) Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics. Nature Reviews Neuroscience 14:233-247.

Wiegert JS, Oertner TG (2013) Long-term depression triggers the selective elimination of weakly integrated synapses. Proc Natl Acad Sci USA 110(47): E4510-E4519

Rose T, Schoenenberger P, Jezek K, Oertner TG (2013) Developmental refinement of vesicle cycling at Schaffer collateral synapses. Neuron 77(6): 1109-21

Karpova A*, Mikhaylova M*, Bera S, Baer J, Reddy PP, Behnisch T, Rankovic V, Spilker C, Bethge P, Sahin J, Kaushik R, Zuschratter W, Kähne T, Naumann M, Gundelfinger ED, Kreutz MR. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell. 2013 Feb 28;152(5):1119-33. * shared first authorship

van Spronsen M*, Mikhaylova M*, Lipka J*, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J, Kapitein LC, Jaarsma D, Gerritsen HC, Akhmanova A, Hoogenraad CC. TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites. Neuron. 2013 Feb 6;77(3):485-502. * shared first authorship

Karpova, A*, Mikhaylova, M*, Bera, S, Bär, J, Reddy, PP, Behnisch, T, Rankovic, V, Spilker, C, Bethge, P, Sahin, J, Kaushik, R, Zuschratter, W, Kähne, T, Naumann, M, Gundelfinger, ED, Kreutz, MR. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell 152: 1119–1133, 2013. *shared first authorship *Research highlight in Nat. Rev. Neuroscience. 10*, *Hot Topic Neuropsychopharmacology

Hoyer D, Dürst T, Fendt M, Jacobson LH, Betschart C, Hintermann S, Behnke D, Cotesta S, Laue G, Ofner S, Legangneux E, Gee CE (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Frontiers in Neuroscience 7:235

Fendt, M, Imobersteg S, Peterlik D, Chaperon F, Mattes C, Wittmann C, Olpe H-R, Mosbacher J, Vranesic I, van der Putten PH, McAllister KH, Flor PJ, Gee CE (2013) Differential roles of mGlu7 and mGlu8 in amygdala-dependent behavior and physiology. Neuropharmacology 72:215-233

Wiegert JS, Oertner TG (2013). Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 110(47), E4510-E4519.

2012

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Bruck W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA (2012) TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Medicine 18:1805-1811.

Huber D, Gutnisky DA, Peron S, O’Connor DH, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K (2012) Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484: 473–478

Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck St, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM. Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 2012 486(7402):256-60

Chaperon F, Fendt M, Kelly PH, Lingenhoehl K, Mosbacher J, Olpe HR, Schmid P, Sturchler C, McAllister KH, van der Putten PH, Gee CE (2012) Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory. PLoS ONE 7(4): e34963

Mang GM, Dürst T, Bürki H, Imobersteg S, Abramowski D, Schuepbach E, Hoyer D, Fendt M, Gee CE (2012) The dual orexin receptor antagonist almorexant induces sleep and decreases orexin induced locomotion by blocking orexin 2 receptors. SLEEP 35:1625-1635

Huber D, Gutnisky DA, Peron S, O'Connor DH, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484, 473-478.

Calderon de Anda F. et al. An Autism Spectrum Disorder Susceptibility Gene, TAO2, is Important for Basal Dendrite Formation in the Neocortex. Nature Neuroscience 15 (2012) 1022-1031.

2011

Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, Kim JS, Breuer L, Singer OC, Warach S, Christensen S, Treszl A, Forkert ND, Galinovic I, Rosenkranz M, Engelhorn T, Köhrmann M, Endres M, Kang DW, Dousset V, Sorensen AG, Liebeskind DS, Fiebach JB, Fiehler J, Gerloff C (on behalf of the STIR and VISTA Imaging Investigators) (2011) MRI identifies acute ischemic stroke patients within a time window for thrombolysis – a multicentre observational study on the predictive value of DWI-FLAIR mismatch for the identification of acute ischemic stroke patients ≤4.5 h of symptom onset (PRE-FLAIR). Lancet Neurol 10: 978-986

Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovich AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur EL, Schmitz D, Kneussel M (2011) Muskelin regulates actin filamentand microtubule-based GABA-AR transport in neurons. Neuron 70:66-81.

Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG (2011) High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci USA 108(18): 7595-600

Brockmann, M.D., Pöschel, B., Cichon, N., Hanganu-Opatz, I.L. (2011) Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat. Neuron 71: 332-347.

2010

Calderon de Anda F.*, Meletis K., Ge X., Rei D., and Tsai L-H.* Centrosome motility is essential for initial axon formation in the neocortex. J. Neurosci., 30(2010) 10391-10406. *Corresponding authors.

Ge X., Frank C. L., Calderon de Anda F., Tsai L-H. Hook3 interacts with the schizophreniaassociated protein PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron, 65(2010) 191-203.