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Research Group Schnabel
AFHRI Cohort Study
Aim:
The goal of our research group is to detect the predisposition to cardiovascular disease as well as the detection of early, reversible stages of the disease in order to enable prevention and early intervention.
Scope of Research
Generation of guideline-relevant data • Risk scores • Prognostic biomarkers • Therapy monitoring • FAIRification • OMICs • Deep Learning • Digitalization
Research Projects
TrackAF, Translational Research and Training PI Axel Löwe Horizon Europe
Triangular relations heart-brain-arrhythmias Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.)
Co-incidence and risk factors for cardiovascular disease Deutsche Herzstiftung (German Heart Foundation)
Systems medicine-based risk stratification for atrial fibrillation Deutsche Herzstiftung (German Heart Foundation)
Hypermarker, Personalised pharmacometabolomic optimisation of treatment for hypertension Horizon 2020, RIA
Metabolome in Cardiovascular Disease Deutsches Zentrum für Herz-Kreislaufforschung (DZHK e.V.)
EU AFFECT-EU Project, Screening Strategy for Atrial fibrillation (grant agreement no. 847770) Horizon 2020
PARIS EraCoSysMed, artificial intelligence for stroke prediction in atrial fibrillation using imaging and omics Horizon 2020/BMBF
Microbiome in atrial fibrillation Deutsches Zentrum für Herz-Kreislaufforschung (DZHK e.V.)
Artificial intelligence methods for myocardial infarction prediction from the resting ECG Deutsche Herzstiftung, Seefried Projektförderung
e:Med Summer School COME, Systems Medicine Cardiovascular Disease (Prof. T. Zeller) Bundesministerium für Bildung und Forschung (BMBF)
Digital surface electrocardiography, digital rhythm monitoring
Digital blood pressure monitoring
Advanced statistical analysis methods
Blood and tissue OMICs
Machine learning algorithms
Group Members
Prof. Dr. med Renate B. Schnabel
Principal Investigator
B. Sc. Adil Ghrib
Data Manager
Dr. med. Amelie H. Ohlrogge
Assistant physician
Dr. Bastiaan Geelhoed
Team abroad
Dr. med. Christin Börschel
Assistant physician
Christine Richter
Study Nurse
M.Sc. Daniel Engler
Research assistant
Dr. med. Elisabeth Unger
Assistant physician
B.Sc. Ferdinand Seum
Research assistant
Dr. med. Julian Kemper
Assistant physician
Dr. med. Kim Rosebrook
Assistant physician
Dr. med. Laura Hannen
Assistant physician
Dr. med. Meraj Neyazi
Assistant physician
M.Sc. Patricia Schlieker
Research assistant
Publications
Sex differences in the relationship of socioeconomic position with cardiovascular disease, cardiovascular risk factors, and estimated cardiovascular disease risk: results of the German National Cohort. Moreno Velásquez I, Peters SAE, Dragano N, Greiser KH, Dörr M, Fischer B, Berger K, Hannemann A, Schnabel RB, Nauck M, Göttlicher S, Rospleszcz S, Willich SN, Krist L, Schulze MB, Günther K, Brand T, Schikowski T, Emmel C, Schmidt B, Michels KB, Mikolajczyk R, Kluttig A, Harth V, Obi N, Castell S, Klett-Tammen CJ, Lieb W, Becher H, Winkler V, Minnerup H, Karch A, Meinke-Franze C, Leitzmann M, Stein MJ, Bohn B, Schöttker B, Trares K, Peters A, Pischon T. Journal of the American Heart Association, 14(5), p.e038708. doi/10.1161/JAHA.124.038708
Hypertension and Atrial Fibrillation: A Frontier Review From the AF-SCREEN International Collaboration. Niiranen TJ, Schnabel RB, Schutte AE, Biton Y, Boriani G, Buckley C, Cameron AC, Damasceno A, Diederichsen SZ, Doehner W, Guo Y, Hobbs FDR, Joung B, Hankey GJ, Lip GYH, Lobban T, Løchen ML, Mairesse G, Mbakwem A, Noseworthy PA, Ntaios G, Steinhubl S, Stergiou G, Svendsen JH, Tieleman RG, Wang J, Poulter NR, Healey JS, Freedman B. Circulation. 2025 Mar 25;151(12):863-877. doi: 10.1161/CIRCULATIONAHA.124.071047. Epub 2025 Mar 24. PMID: 40127157.
Estimation of inlet flow rate in simulations of left atrial flows: A proposed optimized and reference-based algorithm with application to sinus rhythm and atrial fibrillation. Kjeldsberg HA, Schnabel RB, Sundnes J, Valen-Sendstad K. J Biomech. 2025 Apr;183:112594. doi:10.1016/j.jbiomech.2025.112594. Epub 2025 Mar 1. PMID: 40073693.
Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials. Schnabel RB, Benezet-Mazuecos J, Becher N, McIntyre WF, Fierenz A, Lee SF, Goette A, Atar D, Bertaglia E, Benz AP, Chlouverakis G, Birnie DH, Dichtl W, Blomstrom-Lundqvist C, Camm AJ, Erath JW, Simantirakis E, Kutyifa V, Lip GYH, Mabo P, Marijon E, Rivard L, Schotten U, Alings M, Sehner S, Toennis T, Linde C, Vardas P, Granger CB, Zapf A, Lopes RD, Healey JS, Kirchhof P. Eur Heart J. 2024 Dec 7;45(46):4902-4916. doi:10.1093/eurheartj/ehae596. PMID: 39222018; PMCID: PMC11631065.
Atrial fibrillation burden: a new outcome predictor and therapeutic target. Becher N, Metzner A, Toennis T, Kirchhof P, Schnabel RB. Eur Heart J. 2024 Aug 16;45(31):2824-2838. Doi:10.1093/eurheartj/ehae373. PMID: 38953776; PMCID: PMC11328870.
Grants/Awards
Horizon Europe
Deutsches Zentrum für Herz-Kreislaufforschung (DZHK e.V.)
Horizon 2020
Deutsche Herzstiftung, Seefried Projektförderung
Federal Ministry of Research, Technology and Space (BMFTR)
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