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Research Group Magnussen
Aim
We aim to improve cardiovascular risk prediction with a strong focus on public health,big data analysis and global-scale epidemiological efforts.
Scope of Research
Global population science • Classical and emerging cardiovascular risk factors• Age- and sex-specific predictions
Research Projects
1. Simulation of Glucagon-like peptide-1 receptor agonists (GLP1-RA) effects in the primary prevention setting: GLP-1RA have demonstrated significant cardiovascular benefits in individuals with established cardiovascular disease (CVD). However, their potential in the primary prevention of CVD remains largely unexplored. This study aimes to model the potential effect of GLP-1RA therapy on incident CVD events and mortality in a population without pre-existing CVD, using effect estimates derived from the SELECT trial.
2. Itemizing residual CVD risk by integrated analysis of exposomal, genetic and classical cardiovascular risk factors for CVD and mortality. Classical risk factors explain about half of the global 10-year CVD risk. However, substantial residual risk remains. Using the Global Cardiovascular Risk Consortium (GCVRC) dataset, this project aims to assess the relative contributions of exposomal, genetic, and classical risk factors to CVD and all-cause mortality.
3. Sex-specific cardiovascular risk prediction utilizing machine learning to identify exposomal, blood-based, and imaging biomarkers: Women and men differ in incidence, symptoms and prognosis of different CVD subtypes. This project aims to improve early, personalized CVD prediction by developing multimodal, data-driven models that incorporate emerging risk factors and account for sex-specific differences. Key goals include identifying novel exposomal, blood-based, and imaging predictors, quantifying their impact, and translating findings into pragmatic clinical risk prediction tools.
Group Members
Elisa Großmann,
PhD student;
Aisouda Hoshiyar,
statistician;
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Julia Munzinger,
epidemiologist, PhD student;
Thiess Lorenz,
head of data centre, epidemiologist, PhD student;
Publications
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Global Effect of cardiovascular risk factors on lifetime estimates.
Magnussen C, (...), Ojeda F*, Blankenberg S*.
N Engl J Med. Mar 30 2025. DOI:10.1056/NEJMoa2415879 -
Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality
Magnussen C, Ojeda FM, Leong DP, (...), Blankenberg S
N Engl J Med. 2023;389(14):1273-1285. DOI: 10.1056/NEJMoa2206916. -
Prognostic Value of Cardiovascular Biomarkers in the Population.
Neumann JT, (...), Magnussen C, (...) Ojeda F.
1. JAMA 2024;331(22):1898-1909. DOI: 10.1001/jama.2024.5596. -
Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme
Petersen EL, (...), Magnussen C, (...) Blankenberg S.
1. Eur Heart J 2022. DOI: 10.1093/eurheartj/ehab914 -
Early Rhythm Control Therapy in Patients With Atrial Fibrillation and Heart Failure.
Rillig A, Magnussen C, (...), Kirchhof P.
Circulation 2021;144(11):845-858. DOI: 10.1161/CIRCULATIONAHA.121.056323.
Grants/Awards
- German Center for Cardiovascular Research (DZHK; Promotion of women scientists programme; FKZ81X3710112)
- Deutsche Stiftung für Herzforschung
- Dr. Rolf M. Schwiete Stiftung
Prizes
- Becht Research Award of the German Heart Research Foundation (September 2024)
Most important collaboration partners
- The Global Cardiovascular Risk Consortium Investigators
- Max Delbrück Center Berlin
- GCCC cohorts