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Research Group Schrage
Acute Cardiovascular Care
Aim:
We aim to investigate the epidemiology of acute cardiovascular diseases (particularly acute heart failure, cardiac arrest and cardiogenic shock), explore their pathophysiology, investigate risk stratification and diagnosis, and assess treatment strategies with a focus on advanced therapies such as mechanical circulatory support devices.
Scope of Research
acute heart failure • cardiogenic shock • cardiac arrest • mechanical circulatory support • biomarker
Research Projects
1. Epidemiology:
Using large-scale databases, we investigate the incidence, course and outcomes of acute cardiovascular diseases, with a particular focus on the volume-outcome-association for established and new therapies.
2. Phenotyping:
Based on a prospective registry of patients with acute heart failure and cardiogenic shock, we provide a deep phenotyping of patients, aiming to unravel key pathogenetic axes, to improve the diagnosis and risk stratification in the acute situation, as well as to identify new treatment options.
3. Randomised controlled trials:
We have participated in multiple randomised controlled trials as a study site, among them DanGer Shock (NCT01633502) and ECLS-SHOCK (NCT02544594). We also initiated the ongoing randomized controlled UNLOAD ECMO trial (NCT05577195), which assesses the mortality impact of active left ventricular unloading on top of VA-ECMO vs. VA-ECMO alone in patients with severe cardiogenic shock.
Key Techniques
- Conventional statistics
- machine-based learning
- clinical trials
Group Members
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Publications
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Kidney injury in patients with heart failure-related cardiogenic shock: Results from an international, multicentre cohort study
undermeyer J, Kellner C, Beer BN, Besch L, Dettling A, Bertoldi LF, Blankenberg S, Dauw J, Eckner D, Eitel I, Graf T, Horn P, Jozwiak-Nozdrzykowska J, Kirchhof P, Kluge S, Linke A, Landmesser U, Lüsebrink E, Majunke N, Mangner N, Winkler SM, Nordbeck P, Orban M, Pappalardo F, Pauschinger M, Pazdernik M, Proudfoot A, Kelham M, Rassaf T, Reichenspurner H, Scherer C, Schulze PC, Schwinger RHG, Skurk C, Sramko M, Tavazzi G, Thiele H, Villanova L, Morici N, Winzer EB, Westermann D, Schrage B.
Eur J Heart Fail. 2025 May 28. doi: 10.1002/ejhf.3701. -
Incidence and predictors of weaning failure from veno-arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock
Dettling A, Kellner C, Sundermeyer J, Beer BN, Besch L, Bertoldi LF, Blankenberg S, Dauw J, Eckner D, Eitel I, Graf T, Horn P, Jozwiak-Nozdrzykowska J, Kirchhof P, Kluge S, Krais J, von Lewinski D, Linke A, Luedike P, Lüsebrink E, Nordbeck P, Pappalardo F, Pauschinger M, Proudfoot A, Rassaf T, Reichenspurner H, Sag CM, Scherer C, Schulze PC, Schwinger RHG, Skurk C, Sramko M, Tavazzi G, Thiele H, Morici N, Winzer EB, Westermann D, Schrage B, Mangner N.
Eur J Heart Fail. 2025 May;27(5):832-841. doi: 10.1002/ejhf.3583. -
Timing of veno-arterial extracorporeal membrane oxygenation support in patients with cardiogenic shock
Sundermeyer J, Kellner C, Beer BN, Dettling A, Besch L, Blankenberg S, Eitel I, Frank D, Frey N, Graf T, Kirchhof P, Krais J, von Lewinski D, Mangner N, Möbius-Winkler S, Nordbeck P, Orban M, Pauschinger M, Sag CM, Scherer C, Skurk C, Thiele H, Westermann D, Schrage B.
Eur J Heart Fail. 2025 Jan;27(1):40-50. doi: 10.1002/ejhf.3498. -
Early risk stratification in patients with cardiogenic shock irrespective of the underlying cause – the Cardiogenic Shock Score
Beer BN, Jentzer JC, Weimann J, Dabboura S, Yan I, Sundermeyer J, Kirchhof P, Blankenberg S, Schrage B, Westermann D.
Eur J Heart Fail. 2022 Apr;24(4):657-667. doi: 10.1002/ejhf.2449. -
Left Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation: Results From an International, Multicenter Cohort Study
Schrage B, Becher PM, Bernhardt A, Bezerra H, Blankenberg S, Brunner S, Colson P, Cudemus Deseda G, Dabboura S, Eckner D, Eden M, Eitel I, Frank D, Frey N, Funamoto M, Goßling A, Graf T, Hagl C, Kirchhof P, Kupka D, Landmesser U, Lipinski J, Lopes M, Majunke N, Maniuc O, McGrath D, Möbius-Winkler S, Morrow DA, Mourad M, Noel C, Nordbeck P, Orban M, Pappalardo F, Patel SM, Pauschinger M, Pazzanese V, Reichenspurner H, Sandri M, Schulze PC, H G Schwinger R, Sinning JM, Aksoy A, Skurk C, Szczanowicz L, Thiele H, Tietz F, Varshney A, Wechsler L, Westermann D.
Circulation. 2020 Dec;142(22):2095-2106. doi: 10.1161/CIRCULATIONAHA.120.048792.
Grants/Awards
- UNLOAD ECMO - Left Ventricular Unloading to Improve Outcome in
Cardiogenic Shock Patients on VA-ECMO: a prospective, randomized,
controlled, multi-center trial, unrestricted research grant - Timing of active left ventricular unloading in relation to VA-ECMO for
the treatment of cardiogenic shock - Optimizing the treatment algorithm,
unrestricted research grant - Predicting myocardial infarction and mortality from digital ECG using neural networks, Else Kröner-Fresenius-Stiftung
- Predictors of underutilization of CRT and ICD – Identifying areas for improvement, unrestricted research grant
- Applying Large Language Models to Enhance Data Extraction for Clinical Research, German Centre for Cardiovascular Research
- Advanced mathematical solutions for circulating cardiovascular biomolecules, University of Hamburg
Most important collaboration partners
- Prof. Dr. med. Dirk Westermann, MD (Department of Cardiology and Angiology I, University Heart Center Freiburg / Bad Krozingen, Germany)
- Prof. Gianluigi Savarese, MD, PhD (Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden)
- Prof. Dr. med. Holger Thiele, MD (Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Science, Germany)