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Research Group Bannas
Quantitative 4D Flow MRI of Cardiovascular Diseases
Aim:
We aim to visualize and quantify pathological blood flow in cardiovascular diseases using 4D Flow MRI to identify novel diagnostic and prognostic imaging biomarkers.
Scope of Research
4D Flow MRI • cardiovascular imaging • hemodynamics • imaging biomarkers
Research Projects
1. Prognostic Value of 4D Flow MRI in Marfan Syndrome
We investigate whether 4D Flow MRI can predict future aortic dilation in patients with Marfan syndrome. Initial aortic diameters and blood flow patterns are measured, and patients are followed prospectively over several years. The aim is to identify pathological flow patterns as predictive biomarkers for aortic dilation.
2. Prognostic Value of 4D Flow MRI in Surgically Reconstructed Bicuspid Aortic Valves
We perform 4D Flow MRI after surgical reconstruction of bicuspid aortic valves. The goal is to predict, based on initial blood flow patterns, whether valve insufficiency or aortic root dilation will occur over time. The aim is to identify predictive imaging biomarkers for long-term outcomes.
3. Prognostic Value of 4D Flow MRI in Abdominal Aortic Aneurysms
We use 4D Flow MRI to systematically characterize blood flow patterns in abdominal aortic aneurysms. We investigate whether there is a threshold at which flow patterns become pathological. In a long-term study, we also assess whether pathological flow patterns in initially small aneurysms can predict future aneurysm growth.
Key Techniques
- 4D Flow MRI (4D Flow MRI)
- Phase contrast-based flow quantification
- Analysis of hemodynamic imaging biomarkers (e.g., wall shear stress, helical/vortical flow patterns)
Group Members
Publications
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Four-dimensional Flow MRI-based Computational Fluid Dynamics Simulation for Noninvasive Portosystemic Pressure Gradient Assessment in Patients with Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt.
Riedel C, Hoffmann M, Ismahil M, Lenz A, Piecha F, Ristow I, Kluwe J, Schlüter M, Adam G, Schoennagel BP, Reeder SB, Bannas P.
Radiology. 2024 Oct;313(1):e232989. doi: 10.1148/radiol.232989 -
Cluster analysis of 100 Marfan patients based on aortic 4D flow MRI and Z-score: insights into disease heterogeneity and stratification of subgroups.
Lenz A, Bahr F, Riedel C, Wright F, Sinn M, Zhang S, Schuett M, Well L, Adam G, von Kodolitsch Y, Schoennagel BP, Bannas P.
Eur Radiol. 2025 Apr;35(4):2200-2212. doi: 10.1007/s00330-024-11034-6. -
Current Imaging Strategies in Patients with Abdominal Aortic Aneurysms.
Ristow I, Riedel C, Lenz A, Well L, Adam G, Panuccio G, Kölbel T, Bannas P.
Rofo. 2024 Jan;196(1):52-61. doi: 10.1055/a-2119-6448. -
Validation of 4D flow cardiovascular magnetic resonance in TIPS stent grafts using a 3D-printed flow phantom.
Riedel C, Ristow I, Lenz A, Schoennagel BP, Hoffmann M, Piecha F, Adam G, Reeder SB, Bannas P.
J Cardiovasc Magn Reson. 2023 Feb 13;25(1):9. doi: 10.1186/s12968-023-00920-5 -
4D flow cardiovascular magnetic resonance for monitoring of aortic valve repair in bicuspid aortic valve disease.
Lenz A, Petersen J, Riedel C, Weinrich JM, Kooijman H, Schoennagel BP, Adam G, von Kodolitsch Y, Reichenspurner H, Girdauskas E, Bannas P.
J Cardiovasc Magn Reson. 2020 Apr 30;22(1):29. doi: 10.1186/s12968-020-00608-0.
Grants/Awards
- Grant: Evaldas Girdauskas/Peter Bannas
Towards a more standardized bicuspid aortic valve repair: Impact of active aortic annulus remodeling on 4D MRI flow patterns and functional outcome
Else-Kröner-Fresenius-Stiftung
09/2024 - 08/2027
576.418 € - Grant: Peter Bannas/Björn Schönnagel
Fetale 4D Fluss MRT zur Evaluation angeborener Herzfehler mittels MRT-kompatiblem Doppler-Ultraschall-Sensor
DFG
10/2021 - 11/2025
211.650 €