Priv.-Doz. Dr. rer. nat.
Maria Brehm
  • Research assistant
Working area

Location

N21 , 1st Floor
Languages
German (Mother tongue)

Publications

2019

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction
Schneppenheim R, Hellermann N, Brehm M, Klemm U, Obser T, Huck V, Schneider S, Denis C, Tischer A, Auton M, März W, Xu E, Wilmanns M, Zotz R
BLOOD. 2019;133(4):356 - 365.

2018

Genetic and Functional Characterization of ADAMTS13 Variants in a Patient Cohort with Upshaw-Schulman Syndrome Investigated in Germany
Hassenpflug W, Obser T, Bode J, Oyen F, Budde U, Schneppenheim S, Schneppenheim R, Brehm M
THROMB HAEMOSTASIS. 2018;118(4):709-722.

A biophysical view on von Willebrand factor activation
Löf A, Müller J, Brehm M
J CELL PHYSIOL. 2018;233(2):799-810.

2017

Von Willebrand factor processing
Brehm M
HAMOSTASEOLOGIE. 2017;37(1):59-72.

Biophysical approaches promote advances in the understanding of von Willebrand factor processing and function
Löf A, Müller J, Benoit M, Brehm M
Adv Biol Regul. 2017;63:81-91.

Mutual A domain interactions in the force sensing protein von Willebrand factor
Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm M, Gruber H, Netz R, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P
J STRUCT BIOL. 2017;197(1):57-64.

Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping
Tischer A, Machha V, Frontroth J, Brehm M, Obser T, Schneppenheim R, Mayne L, Walter Englander S, Auton M
J MOL BIOL. 2017;429(14):2161-2177.

2016

von Willebrand factor is dimerized by protein disulfide isomerase
Lippok S, Kolšek K, Löf A, Eggert D, Vanderlinden W, Müller J, König G, Obser T, Röhrs K, Schneppenheim S, Budde U, Baldauf C, Aponte-Santamaría C, Gräter F, Schneppenheim R, Rädler J, Brehm M
BLOOD. 2016;127(9):1183-91.

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami
Obser T, Ledford-Kraemer M, Oyen F, Brehm M, Denis C, Marschalek R, Montgomery R, Sadler J, Schneppenheim S, Budde U, Schneppenheim R
J THROMB HAEMOST. 2016;14(9):1725-35.

Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor
Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm M, Gruber H, Netz R, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P
Data Brief. 2016;8:1080-7.

2015

Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions
Aponte-Santamaria C, Huck V, Posch S, Bronowska A, Grässle S, Brehm M, Obser T, Schneppenheim R, Hinterdorfer P, Schneider S, Baldauf C, Grater F
BIOPHYS J. 2015;108(9):2312-21.

Force-sensitive autoinhibition of the von Willebrand factor mediated by inter-domain interactions
Aponte-Santamaría C, Huck V, Posch S, Bronowska A, Grässle S, Brehm M, Obser T, Schneppenheim R, Hinterdorfer P, Schneider S, Baldauf C, Gräter F
BIOPHYS J. 2015;108(9):2312-21.

2014

von Willebrand disease type 2A phenotypes IIC, IID and IIE: A day in the life of shear-stressed mutant von Willebrand factor
Brehm M, Huck V, Aponte-Santamaría C, Obser T, Grässle S, Oyen F, Budde U, Schneppenheim S, Baldauf C, Gräter F, Schneider S, Schneppenheim R
THROMB HAEMOSTASIS. 2014;112(1):96-108.

Platelet-free shear flow assay facilitates analysis of shear-dependent functions of VWF and ADAMTS13
Kraus E, Kraus K, Obser T, Oyen F, Klemm U, Schneppenheim R, Brehm M
THROMB RES. 2014;134(6):1285-1291.

Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase
Kublun I, Ehm P, Brehm M, Nalaskowski M
BIOCHIMIE. 2014;102:117-23.

2013

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA
Brehm M, Wundenberg T, Williams J, Mayr G, Shears S
J CELL SCI. 2013;126(Pt 2):437-44.

Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation
Windhorst S, Lin H, Blechner C, Fanick W, Brandt L, Brehm M, Mayr G
BIOCHEM J. 2013;450(1):115-25.

2012

Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.
Meyer R, Nalaskowski M, Ehm P, Schröder C, Naj X, Brehm M, Mayr G
BIOL CHEM. 2012;393(3):149-160.

The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei.
Nalaskowski M, Metzner A, Brehm M, Labiadh S, Brauer H, Grabinski N, Mayr G, Jücker M
CELL SIGNAL. 2012;24(3):621-628.

2011

Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
Nalaskowski M, Fliegert R, Ernst O, Brehm M, Fanick W, Windhorst S, Lin H, Giehler S, Hein J, Lin Y, Mayr G
J BIOL CHEM. 2011;286(6):4500-4510.

2007

Cloning and characterization of dihydrofolate reductase from a facultative alkaliphilic and halotolerant bacillus strain
Redecke L, Brehm M, Bredehorst R
Extremophiles : life under extreme conditions. 2007;11(1):75-83.

2004

Identification of the actin-binding domain of Ins(1,4,5)P3 3-kinase isoform B (IP3K-B)
Brehm M, Schreiber I, Bertsch U, Wegner A, Mayr G
BIOCHEM J. 2004;382(Pt 1):353-62.

Letzte Aktualisierung aus dem FIS: 15.10.2019 - 04:58 Uhr