Gisa Tiegs
Prof. Dr. rer. nat.
Gisa Tiegs
  • Director of the institute
  • Project leader
Working area


Campus Forschung N27 , Ground Floor, Room number 00.103
German (Mother tongue)



The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis
Neumann K, Ostmann A, Breda P, Ochel A, Tacke F, Paust H, Panzer U, Tiegs G
SCI REP-UK. 2019;9(1):2038.

Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice
Ravichandran G, Neumann K, Berkhout L, Weidemann S, Langeneckert A, Schwinge D, Poch T, Huber S, Schiller B, Hess L, Ziegler A, Oldhafer K, Barikbin R, Schramm C, Altfeld M, Tiegs G
J HEPATOL. 2019;71(4):773-782.


Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2 mice
Barikbin R, Berkhout L, Bolik J, Schmidt-Arras D, Ernst T, Ittrich H, Adam G, Parplys A, Casar C, Krech T, Karimi K, Sass G, Tiegs G
SCI REP-UK. 2018;8(1):16238.

IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN
Diefenhardt P, Nosko A, Kluger M, Richter J, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell R, Stahl R, Steinmetz O
J AM SOC NEPHROL. 2018;29(7):1825-1837.

CEACAM1 in Liver Injury, Metabolic and Immune Regulation
Horst A, Najjar S, Wagener C, Tiegs G
INT J MOL SCI. 2018;19(10):3110.

Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice
Horst A, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert A, Oldhafer K, Weiler-Normann C, Lang K, Singer B, Altfeld M, Diehl L, Tiegs G
HEPATOLOGY. 2018;68(1):200-214.

NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
Neumann K, Schiller B, Tiegs G
INT J MOL SCI. 2018;19(9):2732.


Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort
Bremer L, Goletzke J, Wiessner C, Pagenkemper M, Gehbauer C, Becher H, Tolosa E, Hecher K, Arck P, Diemert A, Tiegs G
EBioMedicine. 2017;26:146-151.

Heme oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice
Kah J, Volz T, Lütgehetmann M, Groth A, Lohse A, Tiegs G, Sass G, Dandri-Petersen M
LIVER INT. 2017;37(8):1128-1137.

A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury
Kleinschmidt D, Giannou A, McGee H, Kempski J, Steglich B, Huber F, Ernst T, Shiri A, Wegscheid C, Tasika E, Hübener P, Huber P, Bedke T, Steffens N, Agalioti T, Fuchs T, Noll J, Lotter H, Tiegs G, Lohse A, Axelrod J, Galun E, Flavell R, Gagliani N, Huber S
J IMMUNOL. 2017;199(12):4078-4090.

RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses
Kluger M, Nosko A, Ramcke T, Goerke B, Meyer M, Wegscheid C, Luig M, Tiegs G, Stahl R, Steinmetz O
CLIN EXP IMMUNOL. 2017;188(1):63-78.

A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
Neumann K, Karimi K, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst A, Tiegs G
J IMMUNOL. 2017;198(1):128-137.

T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN
Nosko A, Kluger M, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2017;28(1):185-196.


Immunology of hepatic diseases during pregnancy
Bremer L, Schramm C, Tiegs G
SEMIN IMMUNOPATHOL. 2016;38(6):669-685.

CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells
Evers B, Engel D, Böhner A, Tittel A, Krause T, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C
J AM SOC NEPHROL. 2016;27(11):3368-3382.

Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro
Galani B, Sahuc M, Sass G, Njayou F, Loscher C, Mkounga P, Deloison G, Brodin P, Rouillé Y, Tiegs G, Séron K, Moundipa P
ARCH VIROL. 2016;161(5):1169-81.

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells
Horst A, Neumann K, Diehl L, Tiegs G
CELL MOL IMMUNOL. 2016;13(3):277-292.

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
KIDNEY INT. 2016;89(1):158-166.

RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN
Kluger M, Meyer M, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2016;27(2):454-465.

The Limonoids TS3 and Rubescin E Induce Apoptosis in Human Hepatoma Cell Lines and Interfere with NF-κB Signaling
Lange N, Tontsa A, Wegscheid C, Mkounga P, Nkengfack A, Loscher C, Sass G, Tiegs G
PLOS ONE. 2016;11(8):e0160843.

A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker J, Saftig P, Schmidt-Arras D
ONCOTARGET. 2016;7(14):17431-41.

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN
Paust H, Riedel J, Krebs C, Turner J, Brix S, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein S, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H, Steinmetz O, Stahl R, Panzer U
J AM SOC NEPHROL. 2016;27(7):1933-42.

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, Logsdon M, Brandner J, Tiegs G, Beauchemin N, Wagener C, Deppert W, Horst A
ONCOTARGET. 2016;7(39):63730-63746.


Acetaminophen/Paracetamol: A history of errors, failures and false decisions
Brune K, Renner B, Tiegs G
EUR J PAIN. 2015;19(7):953-965.

Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring
Karimi K, Keßler T, Thiele K, Ramisch K, Erhardt A, Hübener P, Barikbin R, Arck P, Tiegs G
J HEPATOL. 2015;62(5):1085-91.

Testosterone Suppresses Hepatic Inflammation by the Downregulation of IL-17, CXCL-9, and CXCL-10 in a Mouse Model of Experimental Acute Cholangitis
Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
J IMMUNOL. 2015;194(6):2522-30.

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis
Stoyanov E, Ludwig G, Mizrahi L, Olam D, Schnitzer-Perlman T, Tasika E, Sass G, Tiegs G, Jiang Y, Nie T, Kohler J, Schinazi R, Vertino P, Cedar H, Galun E, Goldenberg D
ONCOTARGET. 2015;6(13):11047-60.

Prenatal Acetaminophen Affects Maternal Immune and Endocrine Adaptation to Pregnancy, Induces Placental Damage, and Impairs Fetal Development in Mice
Thiele K, Solano M, Huber S, Flavell R, Kessler T, Barikbin R, Jung R, Karimi K, Tiegs G, Arck P
AM J PATHOL. 2015;185(10):2805-2818.


Hepatocytes induce Foxp3⁺ regulatory T cells by Notch signaling
Burghardt S, Claass B, Erhardt A, Karimi K, Tiegs G
J LEUKOCYTE BIOL. 2014;96(4):571-7.

Anti-hepatitis C virus activity of crude extract and fractions of Entada africana in genotype 1b replicon systems
Galani Tietcheu B, Sass G, Njayou N, Mkounga P, Tiegs G, Moundipa P
AM J CHINESE MED. 2014;42(4):853-68.

Stat3 Programs Th17-Specific Regulatory T Cells to Control GN
Kluger M, Luig M, Wegscheid C, Goerke B, Paust H, Brix S, Yan I, Mittrücker H, Hagl B, Renner E, Tiegs G, Wiech T, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2014;25(6):1291-302.

B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis
Kluger M, Ostmann A, Luig M, Meyer M, Goerke B, Paust H, Meyer-Schwesinger C, Stahl R, Panzer U, Tiegs G, Steinmetz O
EUR J IMMUNOL. 2014;44(3):683-693.

Identification of HO-1/CO-induced tumor protective genes in HCC
Loscher C, Barikbin R, Schildgen J, Wulf J, Tiegs G, Sass G
2014. Zeitschrift für Gastroenterologie. .

CEACAM1 confers resistance toward oxygen-induced vessel damage in a mouse model of retinopathy of prematurity
Ludewig P, Flachsbarth K, Wegscheid C, Tiegs G, Richard G, Wagener C, Bartsch U, Horst A
INVEST OPHTH VIS SCI. 2014;55(12):7950-7960.

Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia
Rissiek A, Schulze C, Bacher U, Schieferdecker A, Thiele B, Jacholkowski A, Flammiger A, Horn C, Haag F, Tiegs G, Zirlik K, Trepel M, Tolosa E, Binder M
INT J CANCER. 2014;135(10):2370-2379.

New problems arising from old drugs: second-generation effects of acetaminophen
Tiegs G, Karimi K, Brune K, Arck P
Exp Rev Clin Pharmacol. 2014;7(5):655-62.

Hepatic CD141⁺IFNλ⁺ DC subset: one against all?
Wegscheid C, Karimi K, Tiegs G
J HEPATOL. 2014;60(1):9-11.

Matrix Conditions and KLF2-Dependent Induction of Heme Oxygenase-1 Modulate Inhibition of HCV Replication by Fluvastatin
Wüstenberg A, Kah J, Singethan K, Sirma H, Keller A, Perez Rosal S, Schrader J, Loscher C, Volz T, Bartenschlager R, Lohmann V, Protzer U, Dandri M, Lohse A, Tiegs G, Sass G
PLOS ONE. 2014;9(5):e96533.


Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
J IMMUNOL. 2013;191(11):5574-82.

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
Carambia A, Frenzel C, Bruns O, Schwinge D, Reimer R, Hohenberg H, Huber S, Tiegs G, Schramm C, Lohse A, Herkel J
J HEPATOL. 2013;58(1):112-8.

Increased expression of complement regulators CD55 and CD59 on peripheral blood cells in patients with EAHEC O104:H4 infection
Dammermann W, Schipper P, Ullrich S, Zimmermann-Fraedrich K, Schulze Zur Wiesch J, Fründt T, Tiegs G, Lohse A, Lüth S
PLOS ONE. 2013;8(9):e74880.

Inhibition of WNT signalling interferes with HCV replication
Loscher C, Keller A, Perez Rosal S, Lohmann V, Bartenschlager R, Tiegs G, Sass G
2013. Zeitschrift für Gastroenterologie. .

Regulatory T Cell-Derived IL-10 Ameliorates Crescentic GN.
Ostmann A, Paust H, Panzer U, Wegscheid C, Kapffer S, Huber S, Flavell R, Erhardt A, Tiegs G
J AM SOC NEPHROL. 2013;24(6):930-942.

Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation-mediated hepatocarcinogenesis
Potikha T, Stoyanov E, Pappo O, Frolov A, Mizrahi L, Olam D, Shnitzer-Perlman T, Weiss I, Barashi N, Peled A, Sass G, Tiegs G, Poirier F, Rabinovich G, Galun E, Goldenberg D
HEPATOLOGY. 2013;58(1):192-204.

Acetaminophen and pregnancy: short- and long-term consequences for mother and child
Thiele K, Kessler T, Arck P, Erhardt A, Tiegs G
J REPROD IMMUNOL. 2013;97(1):128-39.

Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5)
Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T
J BONE MINER RES. 2013;28(10):2070-80.


Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice
Barikbin R, Neureiter D, Wirth J, Erhardt A, Schwinge D, Kluwe J, Schramm C, Tiegs G, Sass G
HEPATOLOGY. 2012;55(2):553-62.

Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice.
Barikbin R, Neureiter D, Wirth J, Erhardt A, Schwinge D, Kluwe J, Schramm C, Tiegs G, Sass G
HEPATOLOGY. 2012;55(2):553-562.

IL-33--a cytokine which balances on a knife's edge?
Erhardt A, Tiegs G
J HEPATOL. 2012;56(1):7-10.

Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression.
Kah J, Wüstenberg A, Keller A, Sirma H, Montalbano R, Ocker M, Volz T, Dandri-Petersen M, Tiegs G, Sass G
ONCOL REP. 2012;28(3):1077-1083.

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication
Loscher C, Wüstenberg A, Keller A, Lehmann E, Sirma H, Bartenschlager R, Lohmann V, Dandri-Petersen M, Tiegs G, Sass G
2012. Zeitschrift für Gastroenterologie. .

Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN.
Riedel J, Paust H, Turner J, Tittel A, Krebs C, Disteldorf E, Wegscheid C, Tiegs G, Velden J, Mittrücker H, Garbi N, Stahl R, Steinmetz O, Kurts C, Panzer U
J AM SOC NEPHROL. 2012;23(12):1987-2000.

The multiple functions of heme oxygenase-1 in the liver.
Sass G, Barikbin R, Tiegs G
Z GASTROENTEROL. 2012;50(1):34-40.

Sharpin contributes to TNFα dependent NFκB activation and anti-apoptotic signalling in hepatocytes.
Sieber S, Lange N, Kollmorgen G, Erhardt A, Quaas A, Gontarewicz A, Sass G, Tiegs G, Kreienkamp H
PLOS ONE. 2012;7(1):29993.

[Hepatology: from basic science to the clinic].
Thimme R, Tiegs G
Z GASTROENTEROL. 2012;50(1):19.

Preface. Inflammation and cancer.
Tiegs G
DIGEST DIS. 2012;30(5):443-444.


CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.
Erhardt A, Wegscheid C, Claaß B, Carambia A, Herkel J, Mittrücker H, Panzer U, Tiegs G
J IMMUNOL. 2011;186(9):5284-5293.

Transcription factor Fra-1 induces cholangitis and liver fibrosis.
Kireva T, Erhardt A, Tiegs G, Tilg H, Denk H, Haybaeck J, Aigner E, Moschen A, Distler J, Schett G, Zwerina J
HEPATOLOGY. 2011;53(4):1259-1269.

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.
Mayer B, Rehberg M, Erhardt A, Wolf A, Reichel C, Kracht M, Krombach F, Tiegs G, Zahler S, Vollmar A, Fürst R
ARTERIOSCL THROM VAS. 2011;31(10):2240-2250.

Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
Paust H, Ostmann A, Erhardt A, Turner J, Velden J, Mittrücker H, Sparwasser T, Panzer U, Tiegs G
KIDNEY INT. 2011;80(2):154-164.

Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT.
Sass G, Klinger N, Sirma H, Hashemolhosseini S, Hellerbrand C, Neureiter D, Wege H, Ocker M, Tiegs G
INT J ONCOL. 2011;39(2):433-442.

Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9.
Schmerwitz U, Sass G, Khandoga A, Joore J, Mayer B, Berberich N, Totzke F, Krombach F, Tiegs G, Zahler S, Vollmar A, Fürst R
ARTERIOSCL THROM VAS. 2011;31(2):280-288.


Tolerance induction in response to liver inflammation.
Erhardt A, Tiegs G
DIGEST DIS. 2010;28(1):86-92.

Immune-mediated liver injury.
Lohse A, Weiler-Normann C, Tiegs G
J HEPATOL. 2010;52:136-144.

Immune tolerance: what is unique about the liver.
Tiegs G, Lohse A
J AUTOIMMUN. 2010;34:1-6.

CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
Turner J, Paust H, Steinmetz O, Peters A, Riedel J, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker H, Tiegs G, Stahl R, Panzer U
J AM SOC NEPHROL. 2010;21(6):974-985.


Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity.
Biburger M, Theiner G, Schädle M, Schuler G, Tiegs G

Do distinct populations of dorsal root ganglion neurons account for the sensory peptidergic innervation of the kidney?
Ditting T, Tiegs G, Rodionova K, Reeh P, Neuhuber W, Freisinger W, Veelken R
AM J PHYSIOL-RENAL. 2009;297(5):1427-1434.

Autonomous innervation in renal inflammatory disease-innocent bystander or active modulator?
Ditting T, Tiegs G, Veelken R
J MOL MED. 2009;87(9):865-870.

Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia.
Eberhardt M, Neeb L, Vogel E, Tiegs G, Reuter U, Messlinger K, Fischer M
NEUROPEPTIDES. 2009;43(6):483-489.

Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival.
Haimerl F, Erhardt A, Sass G, Tiegs G
J BIOL CHEM. 2009;284(1):495-504.

A novel technique for selective NF-kappaB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion.
Hoffmann F, Sass G, Zillies J, Zahler S, Tiegs G, Hartkorn A, Fuchs S, Wagner J, Winter G, Coester C, Gerbes A, Vollmar A
GUT. 2009;58(12):1670-1678.

The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice.
Kroeger I, Erhardt A, Abt D, Fischer M, Biburger M, Rau T, Neuhuber W, Tiegs G
J HEPATOL. 2009;51(2):342-353.

The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response.
Lehmann E, El-Tantawy W, Ocker M, Bartenschlager R, Lohmann V, Hashemolhosseini S, Tiegs G, Sass G
HEPATOLOGY. 2009;51(2):398-404.


Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors.
Biburger M, Tiegs G
J LEUKOCYTE BIOL. 2008;84(1):264-279.

Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice.
Sass G, Leukel P, Schmitz V, Raskopf E, Ocker M, Neureiter D, Meissnitzer M, Tasika E, Tannapfel A, Tiegs G
INT J CANCER. 2008;123(6):1269-1277.

Autonomic renal denervation ameliorates experimental glomerulonephritis.
Veelken R, Vogel E, Hilgers K, Amann K, Hartner A, Sass G, Neuhuber W, Tiegs G
J AM SOC NEPHROL. 2008;19(7):1371-1378.


IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice.
Erhardt A, Biburger M, Papadopoulos T, Tiegs G
HEPATOLOGY. 2007;45(2):475-485.

Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection.
Protzer U, Seyfried S, Quasdorff M, Sass G, Svorcova M, Webb D, Bohne F, Hösel M, Schirmacher P, Tiegs G
GASTROENTEROLOGY. 2007;133(4):1156-1165.

TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax.
Sass G, Shembade N, Haimerl F, Lamoureux N, Hashemolhosseini S, Tannapfel A, Tiegs G
J IMMUNOL. 2007;179(10):7042-7049.

Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines.
Schmöcker C, Weylandt K, Kahlke L, Wang J, Lobeck H, Tiegs G, Berg T, Kang J
HEPATOLOGY. 2007;45(4):864-869.

Cellular and cytokine-mediated mechanisms of inflammation and its modulation in immune-mediated liver injury.
Tiegs G
Z GASTROENTEROL. 2007;45(1):63-70.


A CD40-CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95.
Assohou-Luty C, Gerspach J, Siegmund D, Müller N, Huard B, Tiegs G, Pfizenmaier K, Wajant H
J MOL MED. 2006;84(9):785-797.


Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells.
Biburger M, Tiegs G
J IMMUNOL. 2005;175(3):1540-1550.

Metalloporphyrins inactivate caspase-3 and -8.
Blumenthal S, Kiemer A, Tiegs G, Seyfried S, Höltje M, Brandt B, Höltje H, Zahler S, Vollmar A
FASEB J. 2005;19(10):1272-1279.

Immune-mediated liver injury.
Herkel J, Schuchmann M, Tiegs G, Lohse A
J HEPATOL. 2005;42(6):920-923.

Kupffer cell-expressed membrane-bound TNF mediates melphalan hepatotoxicity via activation of both TNF receptors.
Kresse M, Latta M, Künstle G, Riehle H, van Rooijen N, Hentze H, Tiegs G, Biburger M, Lucas R, Wendel A
J IMMUNOL. 2005;175(6):4076-4083.

Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling.
Sass G, Shembade N, Tiegs G
BIOCHEM J. 2005;385(Pt 2):537-544.


Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage.
Bang R, Biburger M, Neuhuber W, Tiegs G
J PHARMACOL EXP THER. 2004;308(3):1174-1180.

NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice.
Mühlen K, Schümann J, Wittke F, Stenger S, Nico V, Luc V, Tiegs G
J IMMUNOL. 2004;172(5):3034-3041.

Innervation of immune cells: evidence for neuroimmunomodulation in the liver.
Neuhuber W, Tiegs G
ANAT REC PART A. 2004;280(1):884-892.

Cooperative effect of biliverdin and carbon monoxide on survival of mice in immune-mediated liver injury.
Sass G, Seyfried S, Miguel P, Yamashita K, Kaczmarek E, Neuhuber W, Tiegs G
HEPATOLOGY. 2004;40(5):1128-1135.


Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury.
Bang R, Sass G, Kiemer A, Vollmar A, Neuhuber W, Tiegs G
J PHARMACOL EXP THER. 2003;305(1):31-39.

Close apposition of dynorphin-positive nerve fibres to lymphocytes in the liver suggests opioidergic neuroimmunomodulation.
Kaiser M, Tiegs G, Neuhuber W
Histochem Cell Biol. 2003;120(3):213-221.

The flame retardants tetrabromobisphenol A and tetrabromobisphenol A-bisallylether suppress the induction of interleukin-2 receptor alpha chain (CD25) in murine splenocytes.
Pullen S, Boecker R, Tiegs G
TOXICOLOGY. 2003;184(1):11-22.

Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation.
Samel D, Muller D, Gerspach J, Assohou-Luty C, Sass G, Tiegs G, Pfizenmaier K, Wajant H
J BIOL CHEM. 2003;278(34):32077-32082.

Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice.
Sass G, Soares M, Yamashita K, Seyfried S, Zimmermann W, Eschenhagen T, Kaczmarek E, Ritter T, Volk H, Tiegs G
HEPATOLOGY. 2003;38(4):909-918.

Parenchymal, but not leukocyte, TNF receptor 2 mediates T cell-dependent hepatitis in mice.
Schümann J, Mühlen K, Kiemer A, Vollmar A, Tiegs G
J IMMUNOL. 2003;170(4):2129-2137.

Silibinin protects mice from T cell-dependent liver injury.
Schümann J, Prockl J, Kiemer A, Vollmar A, Bang R, Tiegs G
J HEPATOL. 2003;39(3):333-340.

NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells.
Zhou J, Fandrey J, Schümann J, Tiegs G, Brüne B
AM J PHYSIOL-CELL PH. 2003;284(2):439-446.


In vivo regulation of inducible no synthase in immune-mediated liver injury in mice.
Koerber K, Sass G, Kiemer A, Vollmar A, Tiegs G
HEPATOLOGY. 2002;36(5):1061-1069.

Cytokine expression in three mouse models of experimental hepatitis.
Sass G, Heinlein S, Agli A, Bang R, Schümann J, Tiegs G
CYTOKINE. 2002;19(3):115-120.

TNF tolerance and cytotoxicity in the liver: the role of interleukin-1beta, inducible nitric oxide-synthase and heme oxygenase-1 in D-galactosamine-sensitized mice.
Sass G, Koerber K, Tiegs G
INFLAMM RES. 2002;51(5):229-235.

NFkappaB and caspase-3 activity in apoptotic hepatocytes of galactosamine-sensitized mice treated with TNFalpha.
Tapalaga D, Tiegs G, Angermüller S
J HISTOCHEM CYTOCHEM. 2002;50(12):1599-1609.

Cytokine modulation and suppression of liver injury by a novel analogue of thalidomide.
Thiele A, Bang R, Gütschow M, Rossol M, Loos S, Eger K, Tiegs G, Hauschildt S
EUR J PHARMACOL. 2002;453(2-3):325-334.


Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice.
Sass G, Koerber K, Bang R, Guehring H, Tiegs G
J CLIN INVEST. 2001;107(4):439-447.

Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in Con A-induced liver failure.
Streetz K, Fregien B, Plümpe J, Körber K, Kubicka S, Sass G, Bischoff S, Manns M, Tiegs G, Trautwein C
J IMMUNOL. 2001;167(1):514-523.

Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells.
Willuweit A, Sass G, Schöneberg A, Eisel U, Tiegs G, Clauss M
J IMMUNOL. 2001;167(7):3944-3952.

Low-molecular-weight hyaluronic acid induces nuclear factor-kappaB-dependent resistance against tumor necrosis factor alpha-mediated liver injury in mice.
Wolf D, Schümann J, Koerber K, Kiemer A, Vollmar A, Sass G, Papadopoulos T, Bang R, Klein S, Brüne B, Tiegs G
HEPATOLOGY. 2001;34(3):535-547.


Synergism of Pseudomonas aeruginosa exotoxin A with endotoxin, superantigen, or TNF results in TNFR1- and TNFR2-dependent liver toxicity in mice.
Schümann J, Bluethmann H, Tiegs G
IMMUNOL LETT. 2000;74(2):165-172.

Importance of Kupffer cells for T-cell-dependent liver injury in mice.
Schümann J, Wolf D, Pahl A, Brune K, Papadopoulos T, van Rooijen N, Tiegs G
AM J PATHOL. 2000;157(5):1671-1683.


Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice.
Angermüller S, Schümann J, Fahimi H, Tiegs G
ANN NY ACAD SCI. 1999;887:12-17.

Concanavalin A hepatotoxicity in mice: tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation.
Künstle G, Hentze H, Germann P, Tiegs G, Meergans T, Wendel A
HEPATOLOGY. 1999;30(5):1241-1251.

Pathophysiological mechanisms of TNF during intoxication with natural or man-made toxins.
Schümann J, Tiegs G
TOXICOLOGY. 1999;138(2):103-126.

Requirement of peptidergic sensory innervation for disease activity in murine models of immune hepatitis and protection by beta-adrenergic stimulation.
Tiegs G, Bang R, Neuhuber W
J NEUROIMMUNOL. 1999;96(2):131-143.


Pre-apoptotic alterations in hepatocytes of TNFalpha-treated galactosamine-sensitized mice.
Angermüller S, Künstle G, Tiegs G
J HISTOCHEM CYTOCHEM. 1998;46(10):1175-1183.

Immunomodulating properties of the antibiotic novobiocin in human monocytes.
Lührmann A, Thölke J, Behn I, Schumann J, Tiegs G, Hauschildt S
ANTIMICROB AGENTS CH. 1998;42(8):1911-1916.

Acute hepatotoxicity of Pseudomonas aeruginosa exotoxin A in mice depends on T cells and TNF.
Schümann J, Angermüller S, Bang R, Lohoff M, Tiegs G
J IMMUNOL. 1998;161(10):5745-5754.

Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury.
Tiegs G, Küsters S, Künstle G, Hentze H, Kiemer A, Wendel A
J PHARMACOL EXP THER. 1998;287(3):1098-1104.

Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice.
Trautwein C, Rakemann T, Brenner D, Streetz K, Licato L, Manns M, Tiegs G
GASTROENTEROLOGY. 1998;114(5):1035-1045.

Concanavalin A-induced liver injury triggers hepatocyte proliferation.
Trautwein C, Rakemann T, Malek N, Plümpe J, Tiegs G, Manns M
J CLIN INVEST. 1998;101(9):1960-1969.

Quantification of apoptotic and lytic cell death by video microscopy in combination with artificial neural networks.
Weisser M, Tiegs G, Wendel A, Uhlig S
Cytometry. 1998;31(1):20-28.


Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors.
Gantner F, Küsters S, Wendel A, Hatzelmann A, Schudt C, Tiegs G
J PHARMACOL EXP THER. 1997;280(1):53-60.

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.
Küsters S, Tiegs G, Alexopoulou L, Pasparakis M, Douni E, Künstle G, Bluethmann H, Wendel A, Pfizenmaier K, Kollias G, Grell M
EUR J IMMUNOL. 1997;27(11):2870-2875.

Experimental hepatitis and role of cytokines.
Tiegs G
ACTA GASTRO-ENT BELG. 1997;60(2):176-179.

Ebselen--an in vivo immune response modifier.
Wendel A, Kuesters S, Tiegs G
BIOMED ENVIRON SCI. 1997;10(2-3):253-259.


DNA fragmentation in mouse organs during endotoxic shock.
Bohlinger I, Leist M, Gantner F, Angermüller S, Tiegs G, Wendel A
AM J PATHOL. 1996;149(4):1381-1393.

T cell stimulus-induced crosstalk between lymphocytes and liver macrophages results in augmented cytokine release.
Gantner F, Leist M, Küsters S, Vogt K, Volk H, Tiegs G
EXP CELL RES. 1996;229(1):137-146.

Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice.
Knolle P, Gerken G, Loser E, Dienes H, Gantner F, Tiegs G, Meyer Zum Buschenfelde K, Lohse A
HEPATOLOGY. 1996;24(4):824-829.

Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A.
Küsters S, Gantner F, Künstle G, Tiegs G
GASTROENTEROLOGY. 1996;111(2):462-471.

The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure.
Leist M, Gantner F, Künstle G, Bohlinger I, Tiegs G, Bluethmann H, Wendel A
MOL MED. 1996;2(1):109-124.

Immunotoxicology of T cell-dependent experimental liver injury.
Tiegs G, Gantner F
EXP TOXICOL PATHOL. 1996;48(5):471-476.


Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-alpha.
Barsig J, Küsters S, Vogt K, Volk H, Tiegs G, Wendel A
EUR J IMMUNOL. 1995;25(10):2888-2893.

Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha-induced liver injury through distinct pathways.
Bohlinger I, Leist M, Barsig J, Uhlig S, Tiegs G, Wendel A
HEPATOLOGY. 1995;22(6):1829-1837.

Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice: the role of nitric oxide.
Bohlinger I, Leist M, Barsig J, Uhlig S, Tiegs G, Wendel A
TOXICOL LETT. 1995;82-83:227-231.

Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice.
Gantner F, Leist M, Jilg S, Germann P, Freudenberg M, Tiegs G
GASTROENTEROLOGY. 1995;109(1):166-176.

Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.
Leist M, Gantner F, Bohlinger I, Tiegs G, Germann P, Wendel A
AM J PATHOL. 1995;146(5):1220-1234.

Letzte Aktualisierung aus dem FIS: 13.12.2019 - 06:15 Uhr