• Partner UKE Overview
  • Partner UKE Overview
    Network at UKE
    The Liquid Biopsy Translational Research Network at UKE
    It is part of the Univerity Cancer Center Hamburg (UCCH), one of the top cancer center ("Onkologisches Spitzenzentren")
    Funding
    Funding
    Individual projects are funded by highly competitive EU grants (ERC, IMI, ERA-Net Transcan, Marie Curie-Sklodowaska Training network).

    The Liquid Biopsy Translational Research Network at UKE has been established by Klaus Pantel and is part of the University Cancer Center Hamburg (UCCH, Director: Prof. Carsten Bokemeyer), one of the top cancer centers („Onkologische Spitzenzentren“) funded by the German Cancer Aid („Deutsche Krebshilfe“) which also funds a novel post-graduate training center for clinical and translational scientists („Mildred-Scheel Nachwuchszentrum“) at UCCH focusing on cancer cell dissemination/metastasis and liquid biopsy. The network has published more than 300 reports (mostly on clinical studies in patients with various types of solid tumors) and individual projects are funded by highly competitive EU grants (ERC, IMI, ERA-Net TRANSCAN, Marie Curie-Sklodowska Training networks).

  • Prof Klaus Pantel

    Prof. Klaus Pantel

    Chairman of Institut of Tumorbiologie

    Martinistr. 52

    20246 Hamburg

    Germany

    pantel@uke.de

    Natalie Reimers

    Natalie Reimers, PhD

    Project manager

    Martinistr. 52

    20246 Hamburg

    Germany

    nreimers@uke.de

  • Cancer typesSolid tumors (e.g., prostate, breast, lung, GI-tract, melanoma, bladder, cervical cancer)
    Clinical applicationEarly detection of primary cancer and relaps (MRD), monitoring of therapy response, identification of therapy targets and resistance mechanisms
    Liquid Biopsy sourceBlood, plasma, bone marrow
    Technologies available for Liquid BiopsyCellSearch; Parsortix; others
    BiobankSolid tumors (CTCs, plasma)
    Key publicationsKeller L, Pantel K. Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells. Nat Rev Cancer 2019;19: 553-67.

    Pantel K, Alix-Panabieres C. Liquid biopsy and minimal residual disease - latest advances and implications for cure. Nat Rev Clin Oncol. 2019;16: 409-24.

    Bidard FC, Michiels S, Riethdorf S, Mueller V, Esserman LJ,...Pierga JY, Pantel K. Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis. JNCI. 2018.

    Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jucker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefstrom J, Wilmanns M, Muller V, Pantel K*, Wikman H*. Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2. Cancer Discov. 2015;5: 506-19. (*shared senior authorship)

    Muller C, Holtschmidt J, Auer M, Heitzer E, Lamszus K, Schulte A, Matschke J, Langer-Freitag S, Gasch C, Stoupiec M, Mauermann O, Peine S, Glatzel M, Speicher MR, Geigl JB, Westphal M, Pantel K*, Riethdorf S. Hematogenous dissemination of glioblastoma multiforme. Sci Transl Med. 2014;6: 247ra101. (*shared senior authorship)