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Impact of maternal immune activation on the interleukin-6/T helper 17 – axis for intestinal tissue development and inflammation in children
Prenatal stressors are linked to functional abdominal pain disorders (FAPD), which involve recurrent abdominal pain and gastrointestinal issues such as constipation and diarrhea. We investigate how early-life stress affects CD4 T cell development and examine how changes in immune maturation influences intestinal development and inflammation, using our expertises in immune cell and intestinal organoid systems.
Hypothesis
Team
Prof. Dr. (M.D./Ph.D.)
Madeleine Bunders
Principal Investigator
Project-related publications
Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The S-MML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ. 2019. Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life. Immunity 50. DOI: 10.1016/j.immuni. 2018.12.010.
Möller KJ, Wegner LHM, Malsy J, Baumdick ME, Borggrewe M, Jordan-Paiz A, Jung JM, Martrus G, Kretschmer P, Sagebiel AF, Schreurs RRCE, Hagen SH, Burmester G, Clauditz TS, Pals ST, Boettcher M, Melling N, Sauter G, Tomuschat C, Königs I, Schumacher U, Altfeld M, Bernink JH, Perez D, Reinshagen K, Bunders MJ. 2023. Expanded ILC2s in human infant intestines promote tissue growth. Mucosal Immunol 16:408–421. DOI: 10.1016/j.mucimm.2023.04.004.
Sagebiel AF, Steinert F, Lunemann S, Körner C, Schreurs RRCE, Altfeld M, Perez D, Reinshagen K, Bunders MJ. 2019. Tissue-resident Eomes + NK cells are the major innate lymphoid cell population in human infant intestine. Nat Commun 10. DOI: 10.1038/s41467-018-08267-7.
Schreurs RRCE, Sagebiel AF, Steinert FL, Highton AJ, Klarenbeek PL, Drewniak A, Bakx R, The SML, Ribeiro CMS, Perez D, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ. 2021. Intestinal CD8+ T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities. Mucosal Immunol 14:605–614. DOI: 10.1038/s41385-021-00382-x.
Jordan-Paiz A, Martrus G, Steinert FL, Kaufmann M, Sagebiel AF, Schreurs RRCE, Rechtien A, Baumdick ME, Jung JM, Möller KJ, Wegner L, Grüttner C, Richert L, Thünauer R, Schroeder-Schwarz J, van Goudoever JB, Geijtenbeek TBH, Altfeld M, Pals ST, Perez D, Klarenbeek PL, Tomuschat C, Sauter G, Königs I, Schumacher U, Friese MA, Melling N, Reinshagen K, Bunders MJ. 2023. CXCR5+PD-1++ CD4+ T cells colonize infant intestines early in life and promote B cell maturation. Cell Mol Immunol 20:201–213. DOI: 10.1038/s41423-022-00944-4.
Jung JM, Ching W, Baumdick ME, Hofmann-Sieber H, Bosse JB, Koyro T, Möller KJ, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen SA, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans CA, Altfeld M*, Belderbos M*, Dobner T*, Bunders MJ*. 2021. KIR3DS1 directs NK cell–mediated protection against human adenovirus infections. Sci Immunol 6. DOI: 10.1126/sciimmunol.abe2942.
Baumdick ME, Niehrs A, Degenhardt F, Schwerk M, Hinrichs O, Jordan-Paiz A, Padoan B, Wegner LHM, Schloer S, Zecher BF, Malsy J, Joshi VR, Illig C, Schröder-schwarz J, Möller KJ, Hamburg Intestinal Study Group, Martin MP. Yuki Y, Ozawa M, Sauter J, Schmidt AH, Perez D, Giannou AD Arrington M, Davis, RS, Schumacher U, Sauter G, Huber S, Puelles VG, Melling N, Franke A, Altfeld M*, Bunders M*. 2023. Natural Killer Cells in Ulcerative Colitis946–962. DOI: 10.1053/j.gastro.2023.06.034.
Zecher BF, Ellinghaus D, Schloer S, Niehrs A, Padoan B, Baumdick ME, Yuki Y, Martin MP, Glow D, Schröder- Schwarz J, Niersch J, Brias S, Müller LM, Habermann R, Kretschmer P, Früh T, Dänekas J, Wehmeyer MH, Poch T, Sebode M, Ellinghaus E, Degenhardt F, Körner C, Hoelzemer A, Fehse B, Oldhafer KJ, Schumacher U, Sauter G, Carrington M, Franke A, Bunders MJ, Schramm C*, Altfeld M*. 2023. HLADPA1∗ 02:01∼B1∗01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells. Gut 73:325–337. DOI: 10.1136/gutjnl-2023-329524.
Bunders MJ, Altfeld M. 2020. Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions. Immunity 53:487–495. DOI: 10.1016/j.immuni.2020.08.003.