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Consequences of maternal immune activation on the postnatal responsiveness of fetal haematopoiesis-derived γδ T cells
Previous research shows that certain innate γδ T cells are generated only before birth and cannot be produced efficiently later. These cells develop in the fetal thymus and prepare the body to fight microbiota and pathogens before, during, and after birth. We now aim to study how maternal immune activation affects the postnatal activity of these fetal-derived γδ T cells.
Hypothesis
Team
Prof. Dr. rer. nat.
Immo Prinz
Principal Investigator
Prof. Ph.D
Sarina Ravens
Principal Investigator
André Miguel Vaz Pinto Santos
PhD Student
Ziqing Wang
PhD Student
Project-related publications
Ravens S, Fichtner AS, Willers M, Torkornoo D, Pirr S, Schöning J et al. Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth. Proc Natl Acad Sci U S A 2020; 117: 18649–18660.
Haas JD, Ravens S, Düber S, Sandrock I, Oberdörfer L, Kashani E et al. Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave. Immunity 2012; 37: 48–59.
Sandrock I, Reinhardt A, Ravens S, Binz C, Wilharm A, Martins J et al. Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. J Exp Med 2018; 215: 3006–3018.
Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, Oberdörfer L et al. Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol 2017; 18: 393–401.
León-Lara X, Fichtner AS, Willers M, Yang T, Schaper K, Riemann L et al. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. J Exp Med 2024; 221. doi:10.1084/jem.20231987.
Ravens S, Hengst J, Schlapphoff V, Deterding K, Dhingra A, Schultze-Florey C et al. Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy. Front Immunol 2018; 9: 510.
Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J et al. Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells. Cell Rep 2019; 27: 3657-3671.e4.
Tan L, Fichtner AS, Bruni E, Odak I, Sandrock I, Bubke A et al. A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood. Sci Immunol 2021; 6. doi:10.1126/sciimmunol.abf0125.
Cramer A, Yang T, Riemann L, Almeida V, Kammeyer C, Abu YE et al. Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease. Nat Commun 2024; 15: 9841.