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Maternal Health – Project Area A
The strength of the maternal immune response on maternal health is the amelioration of autoimmune disease activity concurrent with pregnancy. The prevalence of autoimmune disorders has shown a significant increase in recent decades, particularly among females. The onset often occurs during adolescence – typically just a few years before initiating family planning. Several observational studies are available to support that pregnancy is associated with the temporal suppression of inflammatory activity in cell-mediated autoimmune diseases.
This suppression has significant consequences for the course of MS, mirrored by an approx. 80% reduction in relapse rates during the third trimester. Such pregnancy associated reduction exceeds the efficacy of MS treatments available to date. However, a rebound in disease activity is often seen postpartum.
Principal Investigors
Manuel Friese &
Jana Sonner
Principal Investigators
Max Kaufmann &
Stefan Gold
Principal Investigators
Martin Becker &
Jörg Heeren &
Petra Arck
Principal Investigator
Nicola Gagliani
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Principal Investigators
Hans-Willi Mittrücker &
Kristin Thiele
Principal Investigator
Tobias Lenz
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Principal Investigators
Stefan Verlohren &
Sandra M. Blois
Principal Investigator
Silke Meiners
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