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Welcome to the CRC1713
Maternal Immune Activation: Causes and Consequences
“Healthy pregnancies are essential to a healthy society. Maternal immune adaptation sustains the maintenance of healthy pregnancies by mounting immune tolerance towards the fetus. This immune adaptation emerged from the evolution of placental mammals over thousands of years.”
PETRA ARCK, MD – SPEAKER OF THE CRC1713
Department of Obstetrics and Fetal Medicine
“Our aim is to understand the cellular and molecular modulation underlying maternal immune responses during pregnancy and the consequences of Maternal Immune Activation (MIA) for the offspring, specifically fetal immune development and immune response in early childhood.”
ANKE DIEMERT, MD – CO-SPEAKER OF THE CRC1713
Department of Obstetrics and Fetal Medicine
We pursue an interdisciplinary and interprofessional approach, structured in two project areas and. This will enable us to characterize MIA distinctively and to explore the consequences of MIA for the health of pregnant women and their offspring. To address our aims, we will utilize established and novel preclinical models, readily available datasets, and biosamples from longitudinal human pregnancy studies, along with integrated data science approaches.
Our initiative also promotes cross-disciplinary training of early-career scientists, pivotal for advancing the next generation of experts devoted to pregnancy-related research. We envision that our translational approach will enable us to develop accurate and reproducible monitoring tools for immune activation in pregnant women. This will ultimately allow us to translate these findings into practical applications that improve the health and well-being of both mother and child.
Project Areas
Principal Investigators of the CRC1713
Participating Institutions
