Prenatal stress challenge has been linked to disadvantages for children's health later in life, such as an increased risk for chronic immune diseases. The immune system largely develops during fetal life and hence, fetal immune organs may be a vulnerable for prenatal stress challenges. In turn, the impaired fetal immune development may become clinically evident during childhood by the onset of a chronic immune disease. Despite this growing recognition of an increased risk for chronic immune diseases in children in response to prenatal stress, the identification of pathways causally involved in this association is largely missing. We here focus on the role of key stress hormones and glucocorticoids on fetal immune and organ development.