2017

Biophysical approaches promote advances in the understanding of von Willebrand factor processing and function
Löf A, Müller J, Benoit M, Brehm M
Adv Biol Regul. 2017;63:81-91.

Mutual A domain interactions in the force sensing protein von Willebrand factor
Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm M, Gruber H, Netz R, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P
J STRUCT BIOL. 2017;197(1):57-64.

2016

von Willebrand factor is dimerized by protein disulfide isomerase
Lippok S, Kolšek K, Löf A, Eggert D, Vanderlinden W, Müller J, König G, Obser T, Röhrs K, Schneppenheim S, Budde U, Baldauf C, Aponte-Santamaría C, Gräter F, Schneppenheim R, Rädler J, Brehm M
BLOOD. 2016;127(9):1183-91.

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami
Obser T, Ledford-Kraemer M, Oyen F, Brehm M, Denis C, Marschalek R, Montgomery R, Sadler J, Schneppenheim S, Budde U, Schneppenheim R
J THROMB HAEMOST. 2016;14(9):1725-35.

Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor
Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm M, Gruber H, Netz R, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P
Data Brief. 2016;8:1080-7.

2015

Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions
Aponte-Santamaria C, Huck V, Posch S, Bronowska A, Grässle S, Brehm M, Obser T, Schneppenheim R, Hinterdorfer P, Schneider S, Baldauf C, Grater F
BIOPHYS J. 2015;108(9):2312-21.

Force-sensitive autoinhibition of the von Willebrand factor mediated by inter-domain interactions
Aponte-Santamaría C, Huck V, Posch S, Bronowska A, Grässle S, Brehm M, Obser T, Schneppenheim R, Hinterdorfer P, Schneider S, Baldauf C, Gräter F
BIOPHYS J. 2015;108(9):2312-21.

2014

von Willebrand disease type 2A phenotypes IIC, IID and IIE: A day in the life of shear-stressed mutant von Willebrand factor
Brehm M, Huck V, Aponte-Santamaría C, Obser T, Grässle S, Oyen F, Budde U, Schneppenheim S, Baldauf C, Gräter F, Schneider S, Schneppenheim R
THROMB HAEMOSTASIS. 2014;112(1):96-108.

Platelet-free shear flow assay facilitates analysis of shear-dependent functions of VWF and ADAMTS13
Kraus E, Kraus K, Obser T, Oyen F, Klemm U, Schneppenheim R, Brehm M
THROMB RES. 2014;134(6):1285-1291.

Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase
Kublun I, Ehm P, Brehm M, Nalaskowski M
BIOCHIMIE. 2014;102:117-23.

2013

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA
Brehm M, Wundenberg T, Williams J, Mayr G, Shears S
J CELL SCI. 2013;126(Pt 2):437-44.

Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation
Windhorst S, Lin H, Blechner C, Fanick W, Brandt L, Brehm M, Mayr G
BIOCHEM J. 2013;450(1):115-25.

2012

Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.
Meyer R, Nalaskowski M, Ehm P, Schröder C, Naj X, Brehm M, Mayr G
BIOL CHEM. 2012;393(3):149-160.

The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei.
Nalaskowski M, Metzner A, Brehm M, Labiadh S, Brauer H, Grabinski N, Mayr G, Jücker M
CELL SIGNAL. 2012;24(3):621-628.

2011

Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
Nalaskowski M, Fliegert R, Ernst O, Brehm M, Fanick W, Windhorst S, Lin H, Giehler S, Hein J, Lin Y, Mayr G
J BIOL CHEM. 2011;286(6):4500-4510.

2007

Cloning and characterization of dihydrofolate reductase from a facultative alkaliphilic and halotolerant bacillus strain
Redecke L, Brehm M, Bredehorst R
Extremophiles : life under extreme conditions. 2007;11(1):75-83.

Letzte Aktualisierung aus dem FIS: 17.07.2017 - 00:04 Uhr