Lan Kluwe
Priv.-Doz. Dr. rer. nat.
Lan Kluwe
  • Wissenschaftliche Mitarbeiterin
Arbeitsbereich

Standort

O48 , 4. Etage, Raumnummer 418
Sprachen
Deutsch (Muttersprache)

Tätigkeitsschwerpunkte

Publikationen

Zurück
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
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  • 1998
Vor

Managing NF2-associated vestibular schwannomas in children and young adults: review of an institutional series regarding effects of surgery and bevacizumab on growth rates, tumor volume, and hearing quality
Gugel I, Zipfel J, Hartjen P, Kluwe L, Tatagiba M, Mautner V, Schuhmann M
CHILD NERV SYST. 2020 [Epub ahead of print].

Clinical characterization of children and adolescents with NF1 microdeletions
Kehrer-Sawatzki H, Kluwe L, Salamon J, Well L, Farschtschi S, Rosenbaum T, Mautner V
CHILD NERV SYST. 2020 [Epub ahead of print].

Paeoniflorin inhibits tributyltin chloride-induced apoptosis in hypothalamic neurons via inhibition of MKK4-JNK signaling pathway
Cong C, Kluwe L, Li S, Liu X, Liu Y, Liu H, Gui W, Liu T, Xu L
J ETHNOPHARMACOL. 2019;237:1-8.

Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas
Gugel I, Grimm F, Liebsch M, Zipfel J, Teuber C, Kluwe L, Mautner V, Tatagiba M, Schuhmann M
CANCERS. 2019;11(9):.

Management of NF2-associated vestibular schwannomas in children and young adults: influence of surgery and clinical factors on tumor volume and growth rate
Gugel I, Grimm F, Teuber C, Kluwe L, Mautner V, Tatagiba M, Schuhmann M
J NEUROSURG-PEDIATR. 2019;1-9.

Minimal Effect of Bevacizumab Treatment on Residual Vestibular Schwannomas after Partial Resection in Young Neurofibromatosis Type 2 Patients
Gugel I, Kluwe L, Zipfel J, Teuber C, Tatagiba M, Mautner V, Schuhmann M, Grimm F
CANCERS. 2019;11(12):.

Cytocompatibility of Titanium, Zirconia and Modified PEEK after Surface Treatment Using UV Light or Non-Thermal Plasma
Guo L, Smeets R, Kluwe L, Hartjen P, Barbeck M, Cacaci C, Gosau M, Henningsen A
INT J MOL SCI. 2019;20(22):.

Separating Response of Tumor and non-Tumor Cells to Drug In Vitro by Quantifying a Mutation
Kleinpoppen M, Moebius C, Grupp K, Kluwe L, Blessmann M
ANTICANCER RES. 2019;39(4):1777-1783.

Vitamin D receptor expression and serum 25(OH)D concentration inversely associates with burden of neurofibromas
Kluwe L, Hagel C, Friedrich R, Schnabel C, Schön G, Mautner V
EUR J CANCER PREV. 2019;28(3):220-224.

Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
Kopp A, Smeets R, Gosau M, Friedrich R, Fuest S, Behbahani M, Barbeck M, Rutkowski R, Burg S, Kluwe L, Henningsen A
IN VIVO. 2019;33(3):757-762.

Cerebrovascular Insult as Presenting Symptom of Neurofibromatosis Type 2 in Children, Adolescents, and Young Adults
Gugel I, Mautner V, Kluwe L, Tatagiba M, Schuhmann M
Front Neurol. 2018;9:733.

Plasma Electrolytic Oxidation of Titanium Implant Surfaces: Microgroove-Structures Improve Cellular Adhesion and Viability
Hartjen P, Hoffmann A, Henningsen A, Barbeck M, Kopp A, Kluwe L, Precht C, Quatela O, Gaudin R, Heiland M, Friedrich R, Knipfer C, Grubeanu D, Smeets R, Jung O
IN VIVO. 2018;32(2):241-247.

Phenotypic and genotypic overlap between mosaic NF2 and schwannomatosis in patients with multiple non-intradermal schwannomas
Kehrer-Sawatzki H, Kluwe L, Friedrich R, Summerer A, Schäfer E, Wahlländer U, Matthies C, Gugel I, Farschtschi S, Hagel C, Cooper D, Mautner V
HUM GENET. 2018;137(6-7):543-552.

Enriching Stem/Progenitor Cells from Dental Pulp Cells by Low-density Culturing
Zhao Y, Zheng Y, Eichhorn W, Klatt J, Henningsen A, Kluwe L, Friedrich R, Gosau M, Smeets R
IN VIVO. 2018;33(1):23-29.

Piezosurgery for Sagittal Split Osteotomy: Procedure Duration and Postoperative Sensory Perturbation
Köhnke R, Kolk A, Kluwe L, Ploder O
J ORAL MAXIL SURG. 2017;75(9):1941-1947.

Lack of evidence for prognostic value of epidermal growth factor receptor intron-1 CA repeats for oral carcinomas
Precht C, Blessmann M, Kluwe L, Scheld T, Schön G, Henningsen A, Pflug C, Smeets R, Heiland M, Gröbe A
EUR J ORAL SCI. 2017;125(2):95-101.

Effector T cell subclasses associate with tumor burden in neurofibromatosis type 1 patients
Farschtschi S, Park S, Sawitzki B, Oh S, Kluwe L, Mautner V, Kurtz A
CANCER IMMUNOL IMMUN. 2016;65(9):1113-1121.

Attachment, Viability and Adipodifferentiation of Pre-adipose Cells on Silk Scaffolds with and Without Co-expressed FGF-2 and VEGF.
Hanken H, Göhler F, Smeets R, Heiland M, Gröbe A, Friedrich R, Busch C, Blessmann M, Kluwe L, Hartjen P
IN VIVO. 2016;30(5):567-72.

Postoperative bleeding risk for oral surgery under continued rivaroxaban anticoagulant therapy
Hanken H, Gröbe A, Heiland M, Smeets R, Kluwe L, Wikner J, Koehnke R, Al-Dam A, Eichhorn W
CLIN ORAL INVEST. 2016;20(6):1279-82.

The feasibility of immediately loading dental implants in edentulous jaws
Henningsen A, Smeets R, Wahidi A, Kluwe L, Kornmann F, Heiland M, Gerlach T
J PERIODONTAL IMPLANT SCI. 2016;46(4):234-43.

A novel genetic- and cell-based tool for assessing the efficacy and toxicity of anticancer drugs in vitro
Kluwe L, Wei J, Alster I, Hanken H
BIOMED PAP. 2016;160(1):64-9.

The importance of nerve microenvironment for schwannoma development
Schulz A, Büttner R, Hagel C, Baader S, Kluwe L, Salamon J, Mautner V, Mindos T, Parkinson D, Gehlhausen J, Clapp D, Morrison H
ACTA NEUROPATHOL. 2016;132(2):289-307.

Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy
Eichhorn W, Haase M, Kluwe L, Zeuch J, Smeets R, Hanken H, Wehrmann M, Gröbe A, Heiland M, Birkelbach M, Rendenbach C
BIOMED RES INT . 2015;2015:120903.

Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy
Gröbe A, Fraederich M, Smeets R, Heiland M, Kluwe L, Zeuch J, Haase M, Wikner J, Hanken H, Semmusch J, Al-Dam A, Eichhorn W
BIOMED RES INT . 2015;2015:823651.

Lack of evidence for increased postoperative bleeding risk for dental osteotomy with continued aspirin therapy
Hanken H, Tieck F, Kluwe L, Smeets R, Heiland M, Precht C, Eichhorn M, Eichhorn W
ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL. 2015;119(1):17-9.

Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence?
Hanken H, Wilkens R, Riecke B, Al-Dam A, Tribius S, Kluwe L, Smeets R, Heiland M, Eichhorn W, Gröbe A
J CRANIO MAXILL SURG. 2015;43(3):373-5.

Quantitative associations of scalp and body subcutaneous neurofibromas with internal plexiform tumors in neurofibromatosis 1
Jett K, Nguyen R, Arman D, Birch P, Chohan H, Farschtschi S, Fuensterer C, Kluwe L, Friedman J, Mautner V
AM J MED GENET A. 2015;167(7):1518-24.

Efficacy and side-effects of a semi-individualized Chinese herb mixture "Tiáo Gēng Tāng" for menopausal syndrome in China
Jia M, Kluwe L, Liu H, Tang Q, Liu L, Wang Z, Tian L, Zhao L, Chen Y, Friedrich R, Sun Z, Xu L
IN VIVO. 2015;29(1):109-15.

Optimized in vitro procedure for assessing the cytocompatibility of magnesium-based biomaterials
Jung O, Smeets R, Porchetta D, Kopp A, Ptock C, Müller U, Heiland M, Schwade M, Behr B, Kröger N, Kluwe L, Hanken H, Hartjen P
ACTA BIOMATER. 2015;23:354-363.

Preclinical assessment of the anticancer drug response of plexiform neurofibroma tissue using primary cultures
Wei J, Mautner V, Friedrich R, Kluwe L
J CLIN NEUROL. 2015;11(2):172-7.

Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma
Atac A, Riecke B, Assaf A, Gröbe A, Friedrich R, Heiland M, Izbicki J, Kluwe L, Blessmann M
ANTICANCER RES. 2014;34(1):235-8.

Postoperative bleeding risk for cutaneous surgery in the head and neck region with continued phenprocoumon therapy
Eichhorn W, Barsukov E, Al-Dam A, Gröbe A, Smeets R, Eichhorn M, Heiland M, Kluwe L, Blessmann M
J CRANIO MAXILL SURG. 2014;42(5):608-611.

Lack of evidence for increased risk of postoperative bleeding after cutaneous surgery in the head and neck in patients taking aspirin
Eichhorn W, Kluwe L, Heiland M, Gröbe A
BRIT J ORAL MAX SURG. 2014;52(6):527-529.

Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity
Gröbe A, Blessmann M, Hanken H, Friedrich R, Schön G, Wikner J, Harms-Effenberger K, Kluwe L, Heiland M, Pantel K, Riethdorf S
CLIN CANCER RES. 2014;20(2):425-33.

Immunohistochemical and FISH analysis of EGFR and its prognostic value in patients with oral squamous cell carcinoma
Gröbe A, Eichhorn W, Fraederich M, Kluwe L, Vashist Y, Wikner J, Smeets R, Simon R, Sauter G, Heiland M, Blessmann M
J ORAL PATHOL MED. 2014;43(3):205-10.

P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region
Gröbe A, Hanken H, Al-Dam A, Cachovan G, Smeets R, Krohn A, Clauditz T, Grob T, Simon R, Sauter G, Kluwe L, Heiland M, Blessmann M
CLIN ORAL INVEST. 2014;18(1):211-217.

Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity
Klatt J, Gerich C, Gröbe A, Opitz J, Schreiber J, Hanken H, Salomon G, Heiland M, Kluwe L, Blessmann M
J CRANIO MAXILL SURG. 2014;42(6):852-854.

Differences of 25-hydroxyvitamin D3 concentrations in children and adults with neurofibromatosis type 1
Schnabel C, Dahm S, Streichert T, Thierfelder W, Kluwe L, Mautner V
CLIN BIOCHEM. 2014;47(7-8):560-3.

Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo
Wei J, Freytag M, Schober Y, Nockher W, Mautner V, Friedrich R, Manley P, Kluwe L, Kurtz A
PLOS ONE. 2014;9(10):e107760.

Efficacy and selectivity of nilotinib on NF1-associated tumors in vitro
Wei J, Schnabel C, Spyra M, Mautner V, Friedrich R, Hagel C, Manley P, Kluwe L
J NEURO-ONCOL. 2014;116(2):231-6.

Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC)
Blessmann M, Al-Dam A, Hanken H, Assaf A, Riecke B, Klatt J, Simon R, Sauter G, Heiland M, Kluwe L, Gröbe A
J CRANIO MAXILL SURG. 2013;41(8):845-9.

B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice
Gleiss J, Demestre M, Spyra M, Eschenhagen T, Hagel C, Mautner V, Kluwe L, Friedrich R
IN VIVO. 2013;27(6):723-7.

Immunohistochemical analysis of p16 expression, HPV infection and its prognostic utility in oral squamous cell carcinoma
Gröbe A, Hanken H, Kluwe L, Schöllchen M, Tribius S, Pohlenz P, Clauditz T, Grob T, Simon R, Sauter G, Heiland M, Blessmann M
J ORAL PATHOL MED. 2013;42(9):676-81.

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition
Mohan P, Castellsague J, Jiang J, Allen K, Chen H, Nemirovsky O, Spyra M, Hu K, Kluwe L, Pujana M, Villanueva A, Mautner V, Keats J, Dunn S, Lazaro C, Maxwell C
ONCOTARGET. 2013;4(1):80-93.

Cardiac characterization of 16 patients with large NF1 gene deletions
Nguyen R, Mir T, Kluwe L, Jett K, Kentsch M, Müller G, Kehrer-Sawatzki H, Friedman J, Mautner V
CLIN GENET. 2013;84(4):344-9.

Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors
Park S, Sawitzki B, Kluwe L, Mautner V, Holtkamp N, Kurtz A
BMC MED. 2013;11:109.

Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS
Reuss D, Mucha J, Hagenlocher C, Ehemann V, Kluwe L, Mautner V, von Deimling A
PLOS ONE. 2013;8(2):e57152.

Clinical presentation, immunohistochemistry and electron microscopy indicate neurofibromatosis type 2-associated gliomas to be spinal ependymomas.
Hagel C, Stemmer-Rachamimov A, Bornemann A, Schuhmann M, Nagel C, Huson S, Evans D, Plotkin S, Matthies C, Kluwe L, Mautner V
NEUROPATHOLOGY. 2012;32(6):611-616.

Ferritin light chain and squamous cell carcinoma antigen 1 are coreceptors for cellular attachment and entry of hepatitis B virus.
Hao Z, Zheng L, Kluwe L, Huang W
INT J NANOMED. 2012;7:827-834.

Dissecting the clinical phenotype associated with mosaic type-2 NF1 microdeletions.
Kehrer-Sawatzki H, Vogt J, Mußotter T, Kluwe L, Cooper D, Mautner V
NEUROGENETICS. 2012;13(3):229-236.

Allelic drop-out, allele imbalance, or loss of heterozygosity?
Kluwe L
GENE CHROMOSOME CANC. 2012;51(5):521-523.

Internal tumor burden in neurofibromatosis Type I patients with large NF1 deletions.
Kluwe L, Nguyen R, Vogt J, Bengesser K, Mussotter T, Friedrich R, Jett K, Kehrer-Sawatzki H, Mautner V
GENE CHROMOSOME CANC. 2012;51(5):447-451.

Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions.
Mußotter T, Kluwe L, Högel J, Nguyen R, Cooper D, Mautner V, Kehrer-Sawatzki H
BMC MED GENET. 2012;13:98.

Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1.
Nguyen R, Dombi E, Widemann B, Solomon J, Fuensterer C, Kluwe L, Friedman J, Mautner V
ORPHANET J RARE DIS. 2012;7:75.

Tissue-specific differences in the proportion of mosaic large NF1 deletions are suggestive of a selective growth advantage of hematopoietic del(+/-) stem cells.
Roehl A, Mussotter T, Cooper D, Kluwe L, Wimmer K, Högel J, Zetzmann M, Vogt J, Mautner V, Kehrer-Sawatzki H
HUM MUTAT. 2012;33(3):541-550.

Efficacy and side effects of chinese herbal medicine for menopausal symptoms: a critical review.
Xu L, Jia M, Salchow R, Kentsch M, Cui X, Deng H, Sun Z, Kluwe L
Evid Based Complement Alternat Med. 2012;2012:568106.

Characterization of the nonallelic homologous recombination hotspot PRS3 associated with type-3 NF1 deletions.
Zickler A, Hampp S, Messiaen L, Bengesser K, Mussotter T, Roehl A, Wimmer K, Mautner V, Kluwe L, Upadhyaya M, Pasmant E, Chuzhanova N, Kestler H, Högel J, Legius E, Claes K, Cooper D, Kehrer-Sawatzki H
HUM MUTAT. 2012;33(2):372-383.

Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors.
Beert E, Brems H, Daniëls B, Ivo D, Frank V, Schoenaers J, Debiec-Rychter M, Gevaert O, Thomas D, Annick V, de Ravel T, Cichowski K, Kluwe L, Mautner V, Sciot R, Legius E
GENE CHROMOSOME CANC. 2011;50(12):1021-1032.

Effects of splicing mutations on NF2-transcripts: transcript analysis and information theoretic predictions.
Ellis J, Heinrich B, Mautner V, Kluwe L
GENE CHROMOSOME CANC. 2011;50(8):571-584.

MIA is a potential biomarker for tumour load in neurofibromatosis type 1.
Kolanczyk M, Mautner V, Kossler N, Nguyen R, Kühnisch J, Zemojtel T, Jamsheer A, Wegener E, Thurisch B, Tinschert S, Holtkamp N, Park S, Birch P, Kendler D, Harder A, Mundlos S, Kluwe L
BMC MED. 2011;9:82.

Clinical and healthcare status of patients with neurofibromatosis type 1.
Langenbruch A, Augustin M, Granström S, Kluwe L, Mautner V
BRIT J DERMATOL. 2011;165(1):225-227.

Plexiform neurofibromas in children with neurofibromatosis type 1: frequency and associated clinical deficits
Nguyen R, Kluwe L, Fuensterer C, Kentsch M, Friedrich R, Mautner V
J PEDIATR-US. 2011;159(4):652-5.e2.

Plexiform neurofibromas in children with neurofibromatosis type 1: frequency and associated clinical deficits.
Nguyen R, Kluwe L, Fuensterer C, Kentsch M, Friedrich R, Mautner V
J PEDIATR-US. 2011;159(4):652-652.

Cancer stem cell-like cells derived from malignant peripheral nerve sheath tumors.
Spyra M, Kluwe L, Hagel C, Nguyen R, Panse J, Kurtz A, Mautner V, Rabkin S, Demestre M
PLOS ONE. 2011;6(6):21099.

Monozygotic twins discordant for neurofibromatosis type 1 due to a postzygotic NF1 gene mutation.
Vogt J, Kohlhase J, Morlot S, Kluwe L, Mautner V, Cooper D, Kehrer-Sawatzki H
HUM MUTAT. 2011;32(6):2134-2147.

Delineation of the clinical phenotype associated with non-mosaic type-2 NF1 deletions: two case reports.
Vogt J, Nguyen R, Kluwe L, Schuhmann M, Roehl A, Mußotter T, Cooper D, Mautner V, Kehrer-Sawatzki H
J Med Case Rep. 2011;5(1):577.

Chinese herb mix Tiáo-Gēng-Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats.
Xu L, Kluwe L, Zhang T, Li S, Mou Y, Sang Z, Ma J, Lu X, Sun Z
BMC COMPLEM ALTERN M. 2011;11:137.

Large intragenic deletions of the NF2 gene: breakpoints and associated phenotypes.
Abo-Dalo B, Kutsche K, Mautner V, Kluwe L
GENE CHROMOSOME CANC. 2010;49(2):171-175.

A novel third type of recurrent NF1 microdeletion mediated by nonallelic homologous recombination between LRRC37B-containing low-copy repeats in 17q11.2.
Bengesser K, Cooper D, Steinmann K, Kluwe L, Chuzhanova N, Wimmer K, Tatagiba M, Tinschert S, Mautner V, Kehrer-Sawatzki H
HUM MUTAT. 2010;31(6):742-751.

Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model.
Demestre M, Herzberg J, Holtkamp N, Hagel C, Reuss D, Friedrich R, Kluwe L, Andreas V, Mautner V, Kurtz A
J NEURO-ONCOL. 2010;98(1):11-19.

Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.
Hummel T, Jessen W, Miller S, Kluwe L, Mautner V, Wallace M, Lázaro C, Page G, Worley P, Aronow B, Schorry E, Ratner N
CLIN CANCER RES. 2010;16(20):5048-5057.

Clinical characterisation of 29 neurofibromatosis type-1 patients with molecularly ascertained 1.4 Mb type-1 NF1 deletions.
Mautner V, Kluwe L, Friedrich R, Roehl A, Bammert S, Högel J, Spöri H, Cooper D, Kehrer-Sawatzki H
J MED GENET. 2010;47(9):623-630.

Extended runs of homozygosity at 17q11.2: an association with type-2 NF1 deletions?
Roehl A, Cooper D, Kluwe L, Helbrich A, Wimmer K, Högel J, Mautner V, Kehrer-Sawatzki H
HUM MUTAT. 2010;31(3):325-334.

Intrachromosomal mitotic nonallelic homologous recombination is the major molecular mechanism underlying type-2 NF1 deletions.
Roehl A, Vogt J, Mussotter T, Zickler A, Spöti H, Högel J, Chuzhanova N, Wimmer K, Kluwe L, Mautner V, Cooper D, Kehrer-Sawatzki H
HUM MUTAT. 2010;31(10):1163-1173.

Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden.
Thomas L, Kluwe L, Chuzhanova N, Mautner V, Upadhyaya M
NEUROGENETICS. 2010;11(4):391-400.

CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.
Demestre M, Messerli S, Celli N, Shahhossini M, Kluwe L, Mautner V, Maruta H
PHYTOTHER RES. 2009;23(2):226-230.

Genome-wide high-resolution analysis of DNA copy number alterations in NF1-associated malignant peripheral nerve sheath tumors using 32K BAC array.
Mantripragada K, Ståhl d, Díaz T, Patridge C, Menzel U, Andersson R, Kluwe L, Kluwe L, Mautner V, Mautner V, Dumanski J, Upadhyaya M
GENE CHROMOSOME CANC. 2009;48(10):897-907.

Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform neurofibromas.
Steinmann K, Kluwe L, Friedrich R, Mautner V, Cooper D, Kehrer-Sawatzki H
J INVEST DERMATOL. 2009;129(3):615-621.

The spectrum of somatic and germline NF1 mutations in NF1 patients with spinal neurofibromas.
Upadhyaya M, Spurlock G, Kluwe L, Chuzhanova N, Bennett E, Thomas N, Guha A, Mautner V
NEUROGENETICS. 2009;10(3):251-263.

Ral overactivation in malignant peripheral nerve sheath tumors.
Vidya B, Yamoutpoor F, Pan W, Dudek A, Esfandyari T, Piedra M, Babovick-Vuksanovic D, Woo R, Mautner V, Kluwe L, Vries D, George H, Thomas S, Kurtz A, Parada L, Farassati F
MOL CELL BIOL. 2009;29(14):3964-3974.

Alterations in the SMARCB1 (INI1) tumor suppressor gene in familial schwannomatosis.
Boyd C, Smith M, Kluwe L, Balogh A, Maccollin M, Plotkin S
CLIN GENET. 2008;74(4):358-366.

Correlation of nonsense and frameshift mutations with severity of retinal abnormalities in neurofibromatosis 2.
Feucht M, Kluwe L, Mautner V, Richard G
ARCH OPHTHALMOL-CHIC. 2008;126(10):1376-1380.

Absence of cutaneous neurofibromas in an NF1 patient with an atypical deletion partially overlapping the common 1.4 Mb microdeleted region.
Kehrer-Sawatzki H, Schmid E, Fünsterer C, Kluwe L, Mautner V
AM J MED GENET A. 2008;146(6):691-699.

Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals.
Mantripragada K, Caley M, Stephens P, Jones C, Kluwe L, Guha A, Mautner V, Upadhyaya M
GENE CHROMOSOME CANC. 2008;47(3):238-246.

High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization.
Mantripragada K, Spurlock G, Kluwe L, Chuzhanova N, Ferner R, Frayling I, Dumanski J, Guha A, Mautner V, Upadhyaya M
CLIN CANCER RES. 2008;14(4):1015-1024.

Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1.
Mautner V, Asuagbor F, Dombi E, Fünsterer C, Kluwe L, Wenzel R, Widemann B, Friedman J
NEURO-ONCOLOGY. 2008;10(4):593-598.

Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions.
Steinmann K, Kluwe L, Cooper D, Brems H, Thomas D, Legius E, Mautner V, Kehrer-Sawatzki H
EUR J HUM GENET. 2008;16(5):572-580.

Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).
Upadhyaya M, Kluwe L, Spurlock G, Monem B, Majounie E, Mantripragada K, Ruggieri M, Chuzhanova N, Evans D, Ferner R, Thomas N, Guha A, Mautner V
HUM MUTAT. 2008;29(1):74-82.

Germline and somatic NF1 gene mutations in plexiform neurofibromas.
Upadhyaya M, Spurlock G, Monem B, Thomas N, Friedrich R, Kluwe L, Mautner V
HUM MUTAT. 2008;29(8):103-111.

Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors.
Hagel C, Zils U, Peiper M, Kluwe L, Gotthard S, Friedrich R, Zurakowski D, von Deimling A, Mautner V
J NEURO-ONCOL. 2007;82(2):187-192.

Type 2 NF1 deletions are highly unusual by virtue of the absence of nonallelic homologous recombination hotspots and an apparent preference for female mitotic recombination.
Steinmann K, Cooper D, Kluwe L, Chuzhanova N, Senger C, Serra E, Lazaro C, Gilaberte M, Wimmer K, Mautner V, Kehrer-Sawatzki H
AM J HUM GENET. 2007;81(6):1201-1220.

Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype.
Aghi M, Kluwe L, Webster M, Jacoby L, Barker F, Ojemann R, Mautner V, MacCollin M
J NEUROSURG. 2006;104(2):201-207.

Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1.
Lammert M, Friedman J, Roth H, Friedrich R, Kluwe L, Atkins D, Schooler T, Mautner V
J MED GENET. 2006;43(10):810-813.

MRI growth patterns of plexiform neurofibromas in patients with neurofibromatosis type 1.
Mautner V, Hartmann M, Kluwe L, Friedrich R, Fünsterer C
NEURORADIOLOGY. 2006;48(3):160-165.

Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Miller S, Rangwala F, Williams J, Ackerman P, Kong S, Jegga A, Kaiser S, Aronow B, Frahm S, Kluwe L, Mautner V, Upadhyaya M, Muir D, Wallace M, Hagen J, Quelle D, Watson M, Perry A, Gutmann D, Ratner N
CANCER RES. 2006;66(5):2584-2591.

Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.
Raedt T, Stephens M, Heyns I, Brems H, Thijs D, Messiaen L, Stephens K, Lazaro C, Wimmer K, Kehrer-Sawatzki H, Vidaud D, Kluwe L, Marynen P, Legius E
NAT GENET. 2006;38(12):1419-1423.

Malignant peripheral nerve sheath tumors (MPNST) in neurofibromatosis type 1 (NF1): diagnostic findings on magnetic resonance images and mutation analysis of the NF1 gene
Friedrich R, Kluwe L, Fünsterer C, Mautner V
ANTICANCER RES. 2005;25(3A):1699-702.

Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients
Frahm S, Kurtz A, Kluwe L, Farassati F, Friedrich R, Mautner V
Cancer cell international. 2004;4(1):4.

Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients
Frahm S, Mautner V, Brems H, Legius E, Debiec-Rychter M, Friedrich R, Knöfel W, Peiper M, Kluwe L
NEUROBIOL DIS. 2004;16(1):85-91.

Screening 500 unselected neurofibromatosis 1 patients for deletions of the NF1 gene
Kluwe L, Siebert R, Gesk S, Friedrich R, Tinschert S, Kehrer-Sawatzki H, Mautner V
HUM MUTAT. 2004;23(2):111-6.

Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors
Kurtz A, Lueth M, Kluwe L, Zhang T, Foster R, Mautner V, Hartmann M, Tan D, Martuza R, Friedrich R, Driever P, Wong L
MOL CANCER RES. 2004;2(8):433-41.

Ki-67 proliferation-index (MIB-1) of neurofibromas in neurofibromatosis type 1 patients
Friedrich R, Hagel C, Brehme Z, Kluwe L, Mautner V
ANTICANCER RES. 2003;23(2A):953-5.

Constitutional NF1 mutations in neurofibromatosis 1 patients with malignant peripheral nerve sheath tumors
Kluwe L, Friedrich R, Peiper M, Friedman J, Mautner V
HUM MUTAT. 2003;22(5):420.

Molecular study of frequency of mosaicism in neurofibromatosis 2 patients with bilateral vestibular schwannomas
Kluwe L, Mautner V, Heinrich B, Dezube R, Jacoby L, Friedrich R, MacCollin M
J MED GENET. 2003;40(2):109-14.

NF1 mutations in neurofibromatosis 1 patients with plexiform neurofibromas
Kluwe L, Friedrich R, Korf B, Fahsold R, Mautner V
HUM MUTAT. 2002;19(3):309.

Presymptomatic diagnosis for children of sporadic neurofibromatosis 2 patients: a method based on tumor analysis
Kluwe L, Friedrich R, Tatagiba M, Mautner V
GENET MED. 2002;4(1):27-30.

Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas
Kluwe L, Hagel C, Tatagiba M, Thomas S, Stavrou D, Ostertag H, von Deimling A, Mautner V
J NEUROPATH EXP NEUR. 2001;60(9):917-20.

Mutations and allelic loss of the NF2 gene in neurofibromatosis 2-associated skin tumors
Kluwe L, Friedrich R, Hagel C, Lindenau M, Mautner V
J INVEST DERMATOL. 2000;114(5):1017-21.

Allelic loss of the NF1 gene in NF1-associated plexiform neurofibromas
Kluwe L, Friedrich R, Mautner V
CANCER GENET CYTOGEN. 1999;113(1):65-9.

Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients
Rosenbaum C, Kluwe L, Mautner V, Friedrich R, Müller H, Hanemann C
NEUROBIOL DIS. 1998;5(1):55-64.

Trk A, B, and C are commonly expressed in human astrocytes and astrocytic gliomas but not by human oligodendrocytes and oligodendroglioma
Wang Y, Hagel C, Hamel W, Müller S, Kluwe L, Westphal M
ACTA NEUROPATHOL. 1998;96(4):357-64.

Letzte Aktualisierung aus dem FIS: 05.08.2020 - 00:45 Uhr