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| Home > Zentren > Onkologisches Zentrum > Klinik und Poliklinik für Strahlentherapie und Radioonkologie > Labor für Strahlenbiologie und Experimentelle Radioonkologie > Publikationen

Publikationen

2014


Laban S, Atanackovic D, Luetkens T, Knecht R, Busch CJ, Freytag M, Spagnoli G, Ritter G, Hoffmann TK, Knuth A, Sauter G, Wilczak W, Blessmann M, Borgmann K, Muenscher A, Clauditz TS. Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer.Int J Cancer. 2014; 135:1142-1152


Kötter A, Cornils K, Borgmann K, Dahm-Daphi J, Petersen C, Dikomey E, Mansour WY. Inhibition of PARP1-dependent end joining contributes to olaparib-mediated radiosensitization in tumor cells. Mol Oncol 2014; epup


Reuther S, Szymczak S, Raabe A, Borgmann K, Ziegler A, Petersen C, Dikomey E, Hoeller U. Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity. Strahlenther Onkol 2014; accepted.


Parplys AC, Kratz K, Speed MC, Leung SG, Schild D, Wiese C. RAD51AP1-deficiency in vertebrate cells impairs DNA replication. DNA Repair 2014; accepted.


Güster JD, Weissleder S, Busch CJ, Kriegs M, Tribius S, Knecht R, Petersen C, Dikomey E, Rieckmann. Inhibition of PARP but not EGFR results in radiosensitzation of HPV and p16-positive HNSCC cell lines. Radiother Oncol. Accepted.


 

2013


Mansour WY, Borgmann K, Petersen C, Dikomey E, Dahm-Daphi J. The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining. DNA Repair (Amst). 2013;12:1134-42.


Baumann M, Bodis S, Dikomey E, van der Kogel A, Overgaard J, Rodemann HP, Wouters B. Molecular radiation biology/oncology at its best: Cutting edge research presented at the 13th  International Wolfsberg Meeting on Molecular Radiation Biology/Oncology. Radiother Oncol. 2013;108:357-61.


Busch CJ, Kriegs M, Laban S, Tribius S, Knecht R, Petersen C, Dikomey E, Rieckmann T. HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1. Radiother Oncol. 2013; 108:495-9.


Dikomey E. Predictive marker for acute normal tissue toxicity in radiotherapy of non-small cell lung cancer. Strahlenther Onkol. 2013; 189:806-8.


Reuther S, Reiter M, Raabe A, Dikomey E. Effect of irradiation on the expression of DNA repair genes studied in human fibroblasts by real-time qPCR using three methods of reference gene validation. Radiat Environ Biophys. 2013; 52:463-9.


Rieckmann T, Tribius S, Grob TJ, Meyer F, Busch CJ, Petersen C, Dikomey E, Kriegs M. HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity. Radiother Oncol. 2013; 107:242-6.


Saker J, Kriegs M, Zenker M, Heldt JM, Eke I, Pietzsch HJ, Grénman R, Cordes N, Petersen C, Baumann M, Steinbach J, Dikomey E, Kasten-Pisula U. Inactivation of HNSCC cells by 90Y-labeled cetuximab strictly depends on the number of induced DNA double-strand breaks. J Nucl Med. 2013; 54:416-23.


Mansour WY, Bogdanova NV, Kasten-Pisula U, Rieckmann T, Köcher S, Borgmann K, Baumann M, Krause M, Petersen C, Hu H, Gatti RA, Dikomey E, Dörk T, Dahm-Daphi J. Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma. Radiother Oncol. 2013; 106:147-54.


Tennstedt P, Fresow R, Simon R, Marx A, Terracciano L, Petersen C, Sauter G, Dikomey E, Borgmann K. RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma. Int J Cancer. 2013; 132:2118-26.


Reuther S, Metzke E, Bonin M, Petersen C, Dikomey E, Raabe A. No effect of the transforming growth factor β1 promoter polymorphism C-509T on TGFB1 gene expression, protein secretion, or cellular radiosensitivity. Int J Radiat Oncol Biol Phys. 2013; 85:460-5.


Rieckmann T, Kriegs M, Nitsch L, Hoffer K, Rohaly G, Kocher S, Petersen C, Dikomey E, Dornreiter I, Dahm-Daphi J. p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation. Oncogene. 2013; 32:968-75.


Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H, Winqvist R. Heterozygous mutations in PALB2 cause DNA replication and damage response defects. Nat Commun. 2013;4:2578.


Laban S, Steinmeister L, Gleißner L, Grob TJ, Grénman R, Petersen C, Gal A, Knecht R, Dikomey E, Kriegs M. Sorafenib sensitizes head and neck squamous cell carcinoma cells to ionizing radiation. Radiother Oncol. 2013;109:286-92.


Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Res. 2013; 73:6254-63.


Kari V, Karpiuk O, Tieg B, Kriegs M, Dikomey E, Krebber H, Begus-Nahrmann Y, Johnsen SA. A subset of histone H2B genes produces polyadenylated mRNAs under a variety of cellular conditions. PLoS One. 2013; 8:e63745.


Kluth M, Hesse J, Heinl A, Krohn A, Steurer S, Sirma H, Simon R, Mayer PS, Schumacher U, Grupp K, Izbicki JR, Pantel K, Dikomey E, Korbel JO, Plass C, Sauter G, Schlomm T, Minner S. Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions. Mod Pathol. 2013; 26:975-83.


Clauditz T, Wang CJ, Gontarewicz A, Blessmann M, Tennstedt P, Borgmann K, Tribius A, Sauter G, Dalchow C, Knecht R, Münscher A, Wilczak W. Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck. Oral Pathol Med 2013; 42:125-132


Holmström F, Pasetto A, Nähr V, Brass A, Kriegs M, Hildt E, Broderick KE, Chen M, Ahlén G, Frelin L. A synthetic codon-optimized hepatitis C virus nonstructural 5A DNA vaccine primes polyfunctional CD8+ T cell responses in wild-type and NS5A-transgenic mice. J Immunol. 2013; 190:1113-24.


 

2012


Parplys AC, Petermann E, Petersen C, Dikomey E, Borgmann K. DNA double-strand breaks are the irradiation-induced lesions that interfere most strongly with replication forks. Radiother Oncol. 2012; 102:466-471.


Runge R, Hiemann R, Wendisch M, Kasten-Pisula U, Storch K, Zoephel K, Fritz C, Roggenbuck D, Wunderlich G, Conrad K, Kotzerke J. Fully automated interpretation of ionizing radiation-induced γH2AX foci by the novel pattern recognition system AKLIDES®. Int J Radiat Biol. 2012; 88:439-47.


Köcher S, Rieckmann T, Rohaly G, Mansour WY, Dikomey E, Dornreiter I, Dahm-Daphi J. Radiation-induced double-strand breaks require ATM but not Artemis for Homologous recombination during S-ohase. Nuclear Acids Res, 2012 Jun 22. [Epub ahead of print]


Raabe A, Derda K, Reuther S, Szymczak S, Borgmann K, Hoeller U, Ziegler A, Petersen C, Dikomey E. Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy. Radiother Oncol, 2012: 7:65


Jung H, Beck-Bornholdt H-P, Svoboda V, Alberti W, Herrmann T. Late complications after radiotherapy for prostate cancer. Strahlenther Oncol, 2012; 188:965-974


Dikomey E, Dahm-Daphi J, Distel L. Prädiktion von Normal- und Tumorreaktion nach Strahlentherapie. Strahlenther Onkol 2012; 188:304-307


Dikomey E., Borgmann K., Kriegs M., Mansour W., Rieckmann T. Petersen C. Strahlenempfindlichkeit von Tumorzellen. In: Onkologie: Grundlagen, Diagnostik, Therapie, Entwicklungen (Hrsg. Zeller, zur Hausen), ecomed, München, 2012, pp1-19.


Andreassen CN, Dikomey E, Parliament M, West CML. Will SNPs be useful predictors of normal tissue radiosensitivity in the future? Highlights from a scientific debate held at the ESTRO 31 meeting. Radiother Oncol, 105;283-288.


Barnett GC, Elliott RM, Alsner J, Andreassen CN, Abdelhay O, Burnet NG, Chang-Claude J, Coles CE, Gutiérrez-Enríquez S, Fuentes MJ, Alonso MC, Kerns S, Raabe A, Symonds RP, Seibold P, Talbot CJ, Wenz F, Wilkinson J, Yarnold J, Dunning AM, Rosenstein B, West CML, Bentzen SM. Individual patient data meta-analysis shows no association between a SNP regulating TGF-beta 1 secretion and late radiotherapy toxicity. Radiother Oncol, 105:289-295


Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, Fritsch L, Battisti V, Ait-Si-Ali S, Hoffbeck AS, Soutoglou E, Will H. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res. 2012; 40:11363-79.


 

2010-11


Zschenker O, Raabe A, Böckelmann IK, Borstelmann S, Szymczak, Wellek S, Rades D, Hoeller U, Ziegler A, Dikomey E, Borgmann K, Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. Radiother Oncol 2010; 2010;97:26-32


El-Awady RA, Saleh EM, Dahm-Daphi J, Targeting DNA double-strand break repair: is it the right way for sensitizing cells to 5-fluorouracil? Anti-Cancer Drugs 2010; 21:277-287


Storch K, Eke I, Borgmann K, Krause M, Richter C, Becker K, Schröck E, Cordes N, Three-dimensional cell growth confers radioresistance by chromatin density. Cancer Research 2010; 2010;70:3925-3934


Borgmann K, Raabe A, Reuther S, Szymczak S, Schlomm T, Isbarn H, Gomolka M, Busjahn A, Bonin M, Ziegler A, Dikomey E, The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer. Radiotherapy & Oncology 2010; 96:19-24


Mansour WY, Rhein T, Dahm-Daphi J, The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies. Nucleic Acids Research, 2010;38:6065-6077


Kriegs M, Kasten-Pisula, Rieckmann T, Holst K, Saker J, Dahm-Daphi J, Dikomey E, The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining. DNA Repair 2010, 2010;9:889-897


Steinberg F, Gerber SD, Rieckmann T, Trueb B. Rapid fusion and syncytium formation of heterologous cells upon expression of the FGFRL1 receptor. J Biol Chem 2010, 285:37704-37715.


Dikomey E. Determination of DNA damage in vitro. Nuklearmedizin. 2010;49:S64-S68.


Brassat U, Balabanov S, Bali D, Dierlamm J, Braig M, Hartmann U, Sirma H, Gunes C, Wege H, Fehse B, Gontarewicz A, Dikomey E, Borgmann K, Brummendorf TH. Functional p53 is required for effective execution of telomerase inhibition in BCR-ABL-positive CML cells. Exp Hematol 2011;39:66-76.


Tribius S., Ihloff AS, Rieckmann T, Petersen C, Hoffmann M, Impact of HPV status on treatment of squamous cell cancer of the oropharynx: What we know and what we need to know. Cancer Letters 2011; 304:71-79.


Kachnic LA, Li L, Fournier L, Ferraiolo N, Dahm-Daphi J, Borgmann K, Willers H. FANCD2 but not FANCA promotes cellular resistance to type II topoisomerase poisons. Cancer Letters 2011, 305:86-93.


Meyer-Schwesinger C., Lange C., Bröcker V., Agustian PA., Lehmann U., Raabe A., Brinkmeyer M., Kobayashi E., Schiffer M.,_ Büsche G., Kreipe HH:, Thaiss F, Becker JU, Bone marrow–derived progenitor cells do not contribute to podocyte turnover in the puromycin aminoglycoside and renal ablation models in rats. Am J Pathol 2011, 178; 494-499.


Kasten-Pisula U, Saker J, Eicheler W, Krause M, Yaromina A, Meyer-Staeckling S, Scherkl B, Kriegs M, Brandt B, Petersen C, Baumann M, Dikomey E. Cellular and tumour radiosensitivity is correlated to EGFR protein expression level in tumours without egfr amplification. Int J Radiat Oncol Biol Phys 2011, 80:1181-1188.


Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SH, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky N, van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, Hu MCT, Chen DJ, Oren M, Shiloh Y, Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks. Molecular Cell 2011, 41; 529-542.


Myllynen L, Rieckmann T, Dahm-Daphi J, Kasten-Pisula U, Petersen C, Dikomey E, Kriegs M. In tumour cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status. Radiother Oncol. 2011, 101:147-151.


Wang M., Morsbach F., Sander D., Gheorghiu L., Nanda A., Benes C., Kriegs M., Dikomey E., Dahm-Daphi J., Settleman J., Willers H. Inhibition of the EGFR sensitizes NSCLC cells to radiation and etoposide via DNA double-strand break inducible senescence. Cancer Res, 2011; 71:6261-6269.


Dikomey E., Borgmann K., Raabe A., Reuther S. Individuelle Strahlenempfindlichkeit: Molekulare Mechanismen der Zellinaktivierung. Ver. Strahlenschutzkommission, Band 66: 96-110.

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Letzte Änderung: Dr. Ingo Brammer, 07.11.2014