Publications
In Focus
"Nature Events" recommends the meeting (December 2011) at which the TSI-lab will give insights into their current research
Symposium. Offence is the best Defence: Immunology, Tolerance and Regeneration. 30th November - 2nd December 2011.
Journal of Cell Science, 2011 Sep 1;124(Pt 17):3029-37 [pdf, 158 KB]
Immunobiology of naive and genetically modified HLA-class-I-knockdown human embryonic stem cells by Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer
Newsletter ISHLT, August 2011, Volume 3, Issue 3 [pdf, 5,39 MB]
In this issue (page 10): "Current Challenges and Advancements in Stem Cell Research" by Sonja Schrepfer, MD, PhD
Lebendige Wissenschaft - Spitzenforschung Herz-Kreislaufmedizin, October 2009 [pdf, 428 KB]
"Immunbiologie embryonaler Stammzellen" by Sonja Schrepfer, MD, PhD
Laborwelt, Nr. 4 / 2009 - 10. Jahrgang [pdf, 115 KB]
"Analyse der Tumorigenität, des Überlebens und der Migration von Stammzellen" by Sonja Schrepfer, MD, PhD
All Publications
- Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao M, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. HLA I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival. Circulation 2011 (Oct). In press.
- Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao M, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. Immunobiology of naïve and gene-tically-modified HLA I knockdown human embryonic stem cells. J Cell Science 2011. In press.
- Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins R C, Eschenhagen T, Schrepfer S. Bioluminescence Imaging for Assessment of Immune Responses Following Implantation of Engineered Heart Tissue (EHT). J Vis Exp. 2011 Jun 1;(52).
- Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP. Prevention of transplant coronary artery disease by prenylation inhibitors. J Heart Lung Transplant. 2011 Jul;30(7):761-9.
- Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplant. 2010 Nov 5. In press.
- Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S. Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy. J Vis Exp. 2010 Dec 4;(46).
- Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S. Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting. Circulation. 2010 Sep 14;122(11 Suppl):S170-8.
- Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S. Non-volume-loaded heart provides a more relevant heterotopic transplantation model. Transpl Immunol. 2010;23(1-2):65-70.
- Hoffmann J, Glassford AJ, Doyle TC, Robbins RC, Schrepfer S, Pelletier MP. Angiogenic effects despite limited cell survival of bone marrow-derived mesenchymal stem cells under ischemia. Thorac Cardiovasc Surg. 2010 Apr;58(3):136-42.
- Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease. J Vis Exp. 2010 Jan 20;(35).
- Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. LAD-ligation: a murine model of myocardial infarction. J Vis Exp. 2009 Oct 14;(32).
- Deuse T, Blankenberg F, Haddad M, Reichenspurner H, Phillips N, Robbins RC, Schrepfer S. Mechanisms behind Local Immunosuppression Using Inhaled Tacrolimus in Preclinical Models of Lung Transplantation. Am J Respir Cell Mol Biol. 2010;43(4):403-12.
- Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. LAD-ligation: a murine model of myocardial infarction. J Vis Exp. 2009 Oct 14;(32).
- Govaert JA, Swijnenburg RJ, Schrepfer S, Xie X, van der Bogt KE, Hoyt G, Stein W, Ransohoff KJ, Robbins RC, Wu JC. Poor Functional Recovery After Transplantation of Diabetic Bone Marrow Stem Cells in Ischemic Myocardium. J Heart Lung Transplant. 2009;28(11):1158-1165.e1.
- Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. Circulation. 2009 Sep 15;120(11 Suppl):S247-54.
- Deuse T, Ikeno F, Robbins RC, Schrepfer S. Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.J Vis Exp. 2009 Sep 14;(31).
- Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC, Schrepfer S. A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection. Transplantation. 2009 Mar 15;87(5):653-9.
- Van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC.Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation. 2009 Mar 15;87(5):642-52.
- Van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, Swijnenburg RJ, Pearl J, Lee A, Fischbein M, Contag CH, Robbins RC, Wu JC. Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation. 2008 Sep 30;118(14 Suppl):S121-9.
- Schrepfer S, Swijnenburg RJ, Govaert J, Cao F, Ransohoff K, Sheikh A, Haddad M, Connolly A, Davis M, Robbins RC, Wu J. Immunosupressive therapy mitigates immunological rejection of human embryonic stem cell xenographs. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12991-6.
- Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu J. In Vivo Imaging of Embryonic Stem Cells Reveals Patterns of Survival and Rejection Following Transplantation. Stem Cells Dev. 2008 Dec;17(6):1023-9.
- Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S. Novel Immunosuppression: R348, a JAK3- and Syk-inhibitor, attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27;85(6):885-92.
- Deuse T, Hoyt G, Koyanagi T, Robbins RC, Schrepfer S. Prevention and Inhibition but not Reversion of Chronic Allograft Vasculopathy by FK778. Transplantation. 2008 Mar 27;85(6):870-7.
- Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Bergow C, Pelletier MP, Robbins RC, Schrepfer S. Introducing the first polymer-free leflunomide eluting stent. Atherosclerosis 2008 Sep;200(1):126-34
- Rempf C, Ritter A, Schrepfer S, Freitag M, Standl T, Gottschalk A. Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r). Artif Cells Blood Substit Immobil Biotechnol. 2008;36(1):34-44
- Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. FASEB J. 2008; Feb 13.
- Sheikh AY, Schrepfer S, Stein W, West J, Lombard J, Burdon T, Pinsker B, Pelletier MP. Right atrial mass after primary repair of an atrial septal defect: thrombus masquerading as a myxoma. Ann Thorac Surg. 2007 Nov;84(5):1742-4.
- Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fischbein MP, Robbins RC, Pelletier MP. Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease. Am J Transplant. 2007;7:1733-1742.
- Schrepfer S, Deuse T, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP. Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model? Transpl Immunol. 2007;17(4):255-261.
- Schrepfer S, Deuse T, Reichenspurner H, Fischbein MP, Robbins RC, Pelletier MP. Stem cell transplantation: The lung barrier. Transplant Proc. 2007;39(2):573-6.
- Schrepfer S, Deuse T, Pelletier MP, Fischbein MP, Robbins RC, Reichenspurner H. Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection? Transplant Proc. 2007;39(2):569-72.
- Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP. Simplyfied protocol to isolate, purify, and culture expand mesenchymal stem cells. Stem Cell Dev 2007;16(1):105-7.
- Schrepfer S, Deuse T, Hoyt G, Sheikh AY, Hoffmann J, Reichenspurner H, Robbins RC, Pelletier MP. Experimental orthotopic tracheal transplantation: The Stanford technique. Microsurgery. 2007;27(3):187-9.
- Sydow K, Schrepfer S, Franzen O, Detter C, Willems S, Meinertz T, Reichenspurner H. Coincidence of aortic valve stenosis and regurgitation and multiple cardiac papillary fibroelastomas in a young male adult. J Thorac Cardiovasc Surg. 2007;133(2):564-5.
- Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H. FK778 in experimental xenotransplantation - A detailed analysis of drug efficacy. J Heart Lung Transplant. 2007;26(1):70-7.
- Schrepfer S, Deuse T, Sultan K, Münzel T, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H. Restenosis development after mechanical injury: A new field of application for Malononitrilamides? Cardiology. 2006;108(2):128-137.
- Schrepfer S, Deuse T, Münzel T, Schäfer H, Braendle W, Reichenspurner H. The selective estrogen receptor-b agonist biochanin A shows vasculoprotective effects without uterotrophic activity. Menopause. 2006;13(3):489-99.
- Schrepfer S, Deuse T, Sydow K, Schafer H, Detter C, Reichenspurner H. Tracheal allograft transplantation in rats: the role of different immunosuppressants on preservation of respiratory epithelium. Transplant Proc. 2006;38(3):741-4.
- Schrepfer S, Deuse T, Koch-Nolte F, Detter C, Reichenspurner H.FK778: New Cellular and Molecular Mechanisms of Action. Transplant Proc. 2006;38(3):757-61.
- Baldus S, Rudolph V, Roiss M, Ito W, Rudolph T, Eiserich JP, Sydow K, Kubala L, Berglund L, Schrepfer S, Deuse T, Risius T, Klemm H, Reichenspurner H, Meinertz T, Heitzer T. Heparin increases endothelial nitric oxide bioavailability by mobilizing vessel-adherent myeloperoxidase. Circulation 2006;113(15):1871-8. Epub 2006 Apr 10.
- Schrepfer S, Deuse T, Koch-Nolte F, Haddad M, Schwedhelm E, Böger E, Schäfer H, Detter C, Reichenspurner H. Sirolimus and FK778: Two antiproliferative Immunosuppressants with same efficiency but different mechanisms of action in a rat tracheal transplant model. Transpl Int. 2006;19(4):310-8.
- Schrepfer S, Deuse T, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H, Reichenspurner H. FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation. J Heart Lung Transplant 2005; 24(11):1844-54.
- Schrepfer S, Deuse T, Schafer H, Koch-Nolte F, Braendle W, Reichenspurner H. The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system. Transpl Immunol. 2005;15(1):45-53.
- Schrepfer S, Deuse T, Schafer H, Reichenspurner H. FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival. Transpl Int. 2005;18:215-20.
- Schrepfer S, Deuse T, Reichenspurner H. The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose-dependent. Transplantation. 2004;77:509-13.
- Schrepfer S, Deuse T, Koch-Nolte F, Schäfer H, Böger R, Reichenspurner H. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. Transplantation 2004;78:71-77.
- Schrepfer S, Deuse T, Reichenspurner H. New technique for chest opening in mice: U-sternotomy. Microsurgery. 2003;23:274-5.
- Schrepfer S, Deuse T, Detter C, Treede H, Koops A, Boehm D, Willems S, Lacour-Gayet F, Reichenspurner H. Successful resection of a symptomatic right ventricular lipoma. Ann Thorac Surg. 2003;76:1305-7.
- Deuse T, Schrepfer S, Reichenspurner H. Immunosuppression with FK778 and Mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003;76:1627-9.
- Deuse T, Lange V, Schrepfer S, Eigenthaler M, Walter U, Elert O. Correlation between mononuclear infiltration and changes in VASP phosphorylation patterns after heterotopic cardiac transplantation in the rat. Eur Surg Res. 2003;35:6-13.
- Gulbins H, Schrepfer S, Uhlig A, Goldemund A, Oberhoffer M, Reichenspurner H, Meiser B, Reichart B. Myoblasts survive intracardiac transfer and divide further after transplantation. Heart Surg Forum 2002;5:340-4.
- Gulbins H, Anderson I, Kilian E, Schrepfer S, Uhlig A, Kreuzer E, Reichart B. Five years of experience with mitral valve homografts. Thorac Cardiovasc Surg 2002;50:223-9.
