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2009
Werner Dammermann, Bo Zhang, Merle Nebel, Chiara Cordiglieri, Francesca Odoardi, Tanja Kirchberger, Naoto Kawakami, James Dowden, Frederike Schmid, Klaus Dornmair, Martin Hohenegger, Alexander Flügel, Andreas H. Guse, and Barry V. L. Potter
NAADP-mediated Ca2 signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist
Proc Natl. Acad. Sci. USA, im Druck
Kirchberger T, Moreau C, Wagner GK, Fliegert R, Siebrands CC, Nebel M, Schmid F, Harneit A, Odoardi F, Flügel A, Potter BV, Guse AH.
8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.
Biochem J. 2009 Jun 3. [Epub ahead of print] PubMed PMID: 19492987
Schwarz N, Fliegert R, Adriouch S, Seman M, Guse AH, Haag F, Koch-Nolte F.
Activation of the P2X7 ion channel by soluble and covalently bound ligands.
Purinergic Signal. 2009 Jun;5(2):139-49. Epub 2009 Mar 3. PubMed PMID: 19255877; PubMed Central PMCID: PMC2686825
Koch-Nolte F, Haag F, Guse AH, Lund F, Ziegler M.
Emerging roles of NAD+ and its metabolites in cell signaling.
Sci Signal. 2009 Feb 10;2(57):mr1. Review. PubMed PMID: 19211509
Lin, H., Fridy, P.C., Ribeiro, A.A., Choi, J.H., Barma, D.K., Vogel, G., Falck, J.R., Shears, S.B., York, J.D., Mayr, G.W.
Structural Analysis and Detection of Biological Inositol Pyrophosphates Reveal That the Family of VIP/Diphosphoinositol Pentakisphosphate Kinases Are 1/3-Kinases. J. Biol. Chem. 284, 1863-72 [Epub ahead of print 2008 Nov 3]
Metzner, A., Precht, C., Fehse, B., Fiedler, W., Stocking, C., Günther, A., Mayr, G.W., Jücker, M.
Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D. Gene Ther. [Epub ahead of print Jan 15. 2009]
Lin, H., Lindner, K., Mayr, G.W.
Synthesis and non-radioactive micro-analysis of diphosphoinositol phosphates by HPLC with post column complexometry. In: Methods in Molecular Biology: Inositol Phosphates and Lipids (Barker, C. J., ed), Humana Press Inc., Totowa, NJ.
2008
Hoxha, E., Fehse, B., Ortmeyer, G., Stocking, C., Mayr, G.W., Jücker, M.
Overexpression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase inhibits GM-CSF-dependent colony formation of CD34+ hematopoietic progenitor cells. Leuk. Lymphoma, 49, 1206-08
Böer, U., Cierny. I., Krause. D., Heinrich, A., Lin, H., Mayr, G., Hiemke, C., Knepel, W.
Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice
Neuropsychopharmacology 33, 2407-15 [Epub ahead of print 2007 Nov 28]
Guse AH, Lee HC
NAADP: a universal Calcium trigger
Sci Signal. 2008
Windhorst S, Blechner C, Lin HY, Elling C, Nalaskowski M, Kirchberger T, Guse AH, Mayr GW.
Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.
Biochem J. 2008 Sep 15;414(3):407-17.
Guse AH.
Back from the dormant stage: second messenger cyclic ADP-ribose essential for Toxoplasma gondii pathogenicity.
Sci Signal. 2008 Apr 29;1(17):pe18. Review.
Zhang B, Wagner GK, Weber K, Garnham C, Morgan AJ, Galione A, Guse AH, Potter BV.
2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.
J Med Chem. 2008 Mar 27;51(6):1623-36. Epub 2008 Feb 28.
Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse AH, Seman M, Haag F, Koch-Nolte F.
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.
FASEB J. 2008 Mar;22(3):861-9. Epub 2007 Oct 10.
Takashi Kudoh, Takashi Murayama, Minako Hashii, Haruhiro Higashida, Takashi Sakurai, Clarisse Maechling, Bernard Spiess, Karin Weber, Andreas H. Guse, Barry V.L. Potter, Mitsuhiro Arisawa, Akira Matsuda and Satoshi Shuto. Design and synthesis of 4#,6#-unsaturated cyclic ADP-carbocyclic-ribose, a Ca2+-mobilizing agent selectively active in T cells, Tetrahedron Volume 64, Issue 41, 2008, 9754-9765
Takashi Kudoh, Karin Weber, Andreas H. Guse, Barry V. L. Potter, Minako Hashii, Haruhiro Higashida, Mitsuhiro Arisawa, Akira Matsuda, Satoshi Shuto, Design and synthesis of 4",6"-unsaturated cyclic ADP-carbocyclic ribose as a Ca2+-mobilizing agent, Tetrahedron Letters 49 (2008) 3976-3979
Wulf A, Wetzel MG, Kebenko M, Kröger M, Harneit A, Merz J, Weitzel JM.
The role of thyroid hormone receptor DNA binding in negative thyroid hormone-mediated gene transcription.
J Mol Endocrinol. 2008 Jul;41(1):25-34.
Wulf A, Harneit A, Kröger M, Kebenko M, Wetzel MG, Weitzel JM.
T3-mediated expression of PGC-1alpha via a far upstream located thyroid hormone response element.
Mol Cell Endocrinol. 2008 Jun 11;287(1-2):90-5. Epub 2008 Feb 3.
Metzner, A., Horstmann, M.A., Fehse, B., Ortmeyer, G., Niemeyer, C.M., Stocking, C., Mayr, G.W., Jücker, M.
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations. Gene Ther. 14, 699-703 [Epub ahead of print 2007 May 22]
Kasten-Pisula, U., Windhorst. S., Dahm-Daphi, J., Mayr, G.W., Dikomey, E.
Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. Radiother. Oncol. 83, 296-303 [Epub ahead of print 2007 May 22]
Seibel NM, Eljouni J, Nalaskowski MM, Hampe W.
Nuclear localization of enhanced green fluorescent protein homomultimers.
Anal Biochem. 2007 Sep 1; 368(1):95-9. Epub 2007 May 26.
Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza-Toledo A, Bhagat H, Walseth TF, Guse AH, Lund FE
Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by ADP-ribose, the major product generated by the CD38 enzyme reaction.
J. Immunol. in press (2007)
Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse AH, Seman M, Haag F, Koch-Nolte F
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.
FASEB J, in press 2007
Kretschmer B, Lüthje K, Guse AH, Ehrlich S, Koch-Nolte F, Haag F, Fleischer B, Breloer M
CD83 Modulates B Cell Function InVitro: Increased IL-10 and Reduced Ig Secretion by CD83Tg B Cells.
PLOS One 2 (1): e755, 2007.
Schwoerer AP, Blutner C, Brandt S, Binder S, Siebrands CC, Ehmke H, Friederich P
Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization.
Anesthesiology. 2007 May;106 (5): 967-76.
Siebrands CC, Friederich P
Structural requirements of human ether-a-go-go-related gene channels for block by bupivacaine.
Anesthesiology. 2007 Mar; 106 (3): 523-31.
Siebrands CC, Friederich P
Inhibition of HERG channels by the local anaesthetic articaine.
Eur J Anaesthesiol. 2007 Feb; 24 (2): 148-53.
Steen M, Kirchberger T, Guse AH
NAADP mobilizes calcium from the endoplasmic reticular Ca2+ store in T-lymphocytes.
J Biol Chem. 2007 Jun 29; 282 (26): 18864-71.
Brehm MA, Schenk TMH, Zhou X, Fanick W, Lin H, Windhorst S, Nalaskowski MM, Mayr GW
Intracellular localization of human Inositol 1,3,4,5,6-pentakisphosphate 2-kinase.
Biochem J. 2007 Dec 15;408(3):335-45
Weidtmann K, Harendza S, Dietsche S, Guse AH, Middendorff R, Schultz J-H, Mihalache I, Frost M, Kuhnigk O
Konzept und studentische Evaluation der integriertn Seminare im Studienabschnitt "Medizin I" der Medizinischen Fakultät der Universität Hamburg
GMS Z. Med. Ausbild 2007; 24(2):Doc105 (20070523)
Gentsch M, Kuschel M, Schlegel S, Barth G
Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica.
FEMS Yeast Res. 2007 Jan 17; [Epub ahead of print]
Zhang L, Guse AH
Cyclic ADP-ribose analogues with minimal structure: synthesis and calcium release activity, in "Drug Discovery Research in the Post Genomic Era".
(Ed. Ziwei Huang), pp 186-202, Wiley-Interscience, Hoboken NJ, 2007, ISBN 978-0-471-67200-5
Fliegert R, Glassmeier G, Schmid F, Cornils K, Genisyuerek S, Harneit A, Schwarz JR, Guse AH
Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b.
FEBS J 274, 704 - 713
Fliegert R, Gasser A, Guse AH
Regulation of calcium signalling by adenine-based second messengers.
Biochem Soc Trans 35, 109 - 114
Xu J, Yang Z, Dammermann W, Zhang L, Guse AH, Zhang LH
Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains.
J Med Chem 49, 5501 - 5512
Moreau C, Wagner GK, Weber K, Guse AH, Potter BVL
Structural determinants for N1/N7 cyclization of nicotinamide hypoxanthine 5'-dinucleotide (NHD+) derivatives by ADP-ribosyl cyclase from aplysia californica: Ca2+-mobilizing activity of 8-substituted cyclic inosine 5'-diphosphoribose analogues in T-lymphocytes.
J Med Chem 49, 5162 - 5176
Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund FE, Zhang L, Potter BVL, Guse AH
Cellular effects and Metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives.
Brit J Pharmacol 149, 337 - 344
Kuhnigk O, Weidtmann K, Dietsche S, Guse AH, Mihalache I, Schultz JH, Middendorff R, Kadula H, Harendza S
Vom "vorklinischen Studienabschnitt" zu "Medizin I"
GMA Zeitschrift Med. Ausbildung - in press
Ehmann F, Horn S, Garcia-Palma L, Wegner W, Fiedler W, Giehl K, Mayr GW, Jücker M
Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
Leukemie Lymphoma - in press
Gasser A, Bruhn S, Guse AH
Second messenger function of nicotinic acid adenine dinucleotide phosphate (NAADP) revealed by an improved enzymatic cycling assay.
J Biol Chem 281, 16906 - 16913
Nalaskowdki N, Windhorst S, Stockebrandt MC, Mayr GW
Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytopasmic shuttling indicates devergent roles of the catalytic and N-terminal domains.
Biol Chem 387, 583 - 593
Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, Hein D, Krueger S, Weber K, Heiner I, Oppenheimer N, Schwarz JR, Guse AH.
Activation of T cell calcium influx by the second messenger ADP-ribose.
J Biol Chem 281, 2489 - 2496
Kudoh T, Fukuoka M, Ichikawa S, Murayama T, Ogawa Y, Hashii M, Higashida H, Kunerth S, Weber K, Guse AH, Potter BVL, Matsuda A, Shuto S
Synthesis of Stable and Cell-type Selective Analogues of Cyclic ADP-Ribose, a Ca2+-Mobilizing Second Messenger. StructureActivity Relationship of the "Northern" Ribose Moiety.
J Am Chem Soc 127, 8846 - 8855
Wagner GK, Guse AH, Potter BVL
Rapid synthetic route towards structurally modified derivatives of cyclic adenosine 5'-diphosphate ribose.
J Org Chem 70, 4810 - 4819
Gasser A, Guse AH
Determination of intracellular concentrations of the TRPM2 agonist ADP-ribose by reversed phase HPLC.
J Chromatogr B 821, 181 - 187
Dammermann W, Guse AH
Functional ryanodine receptor expression is required for NAADP-mediated local CA2+ signaling in T-lymphocytes.
J Biol Chem 280, 21394 - 21399
Guse AH, Gu X, Zhang L, Weber K, Krämer E, Yang Z, Jin H, Li Q, Carrier L, Zhang L
A minimal structural analogue of cyclic ADP-ribose: Synthesis and calcium release activity in mammalian cells.
J Biol Chem 280, 15952-15959
Mayr GW, Windhorst S, Hillemeier K
Antiproliferative Plant and Synthetic Polyphenolics are Specific Inhibitors of Vertebrate Inositol 1,4,5-trisphosphate 3-Kinases and Inositol Polyphosphate Multikinase.
J Biol Chem 280, 13229 - 13240
Horn S, Endl E, Fehse B, Weck M, Mayr GW, Jücker M
Restoration of SHIP activity in a human leukemia cell line down-regulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3ß signaling and leads to an increased transit time through the G1 phase of the cell cycle.
Leukemia 18, 1839 - 1849
Stuermer CAO, Langhorst MF, Wiechers M, Legler DF, Hannbeck von Hanwehr S, Guse AH, Plattner H
PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction.
Faseb J 18, 1731 - 1733
Brehm MA, Schreiber I, Bertsch U, Wegner A, Mayr GW
Identification of the actin-binding domain of inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3K-B).
Biochem J 382, 353 - 362
Gu X, Yang Z, Zhang L, Kunerth S, Fliegert R, Weber K, Guse AH
Synthesis and biological evaluation of novel membrane-permeant cyclic ADP-ribose mimics: N1-[(5''-O-Phosphorylethoxy)-methyl]-5'-O-phosphorylinosine 5',5''-cyclicpyrophosphate (cIDPRE) and 8-Substituted Derivatives.
J Med Chem 47, 5674 - 5682
Lorke DE, Gustke H, Mayr GW
An optimized fixation and extraction technique for high resolution of inositol phosphate signals in rodent brain.
Neurochem Res 29, 1887-1896
Langhorst MF, Schwarzmann N, Guse AH
Ca2+ release via ryanodine receptors and Ca2+ entry: major mechanisms inNAADP-mediated Ca2+ signaling in T-lymphocytes.
Cell Signal 16, 1283-1289
Kunerth S, Langhorst MF, Schwarzmann N, Gu X, Huang L, Yang Z, Zhang L, Mills SJ, Zhang L-h, Potter BVL, Guse AH
Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells.
J Cell Sci 117, 2141-2149
Lin H, Hoffmann F, Rozkov A, Enfors S-O, Rinas U, Neubauer P
Change of Extracellular cAMP Concentration is a Sensitive Reporter für Bacterial Fitness in High-Cell-Density Cultures of Escherichia coli.
Biotechnol Bioeng 87, 602-613
Koch C, Strätling WH
DNA Binding of Methyl-CpG-Binding Protein MeCP2 in Human MCF7 Cells.
Biochemistry 43, 5011 - 5021
Georgieva DN, Genov N, Perbandt M, Voelter W, Betzel C
Contribution of disulfide bonds and calcium to molluscan hemocyanin stability.
Z Naturforsch C 59, 281-287
Burmeister C, Perbandt M, Betzel C, Walter RD, Liebau E
Native and Inhibited Structure of a Mu-Class Glutathione S-Transferase from Plasmodium falciparum.
J Biol Chem 279, 1336-1342
Kuriakose TA, Kalkura SN, Palanichamy M, Arivuoli D, Dierks K, Bocelli G, Betzel C
Synthesis of stoichiometric nano crystalline hydroxyapatite by ethanol-based sol-gel technique at low temperature.
J Cryst Growth 263, 517-523
Georgieva DN, Perbandt M, Rypniewski W, Hristov K, Genov N, Betzel C
The X-ray structure of a snake venom Gln48 phospholipase A(2) at 19 angstrom resolution reveals anion-binding sites.
Biochem Bioph Res Co 316, 33-38
Georgieva D, Genov N, Hristrov K, Dierks K, Betzel C
Interactions of the Neurotoxin Vipoxin in Solution Studied by Dynamic Light Scattering.
Biophys J 86, 92-92
Guse AH
Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR).
Curr Med Chem 11, 847-856
Guse AH
Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR).
Curr Mol Med 4, 239-248
Nalaskowski M, Mayr GW
The families of kinases removing the Ca2+ releasing second messenger Ins(1,4,5)P3.
Curr Mol Med 4, 277-290
Vallazza M, Perbandt M, Klussmann S, Rypniewski W, Einspahr HM, Erdmann VA, Betzel C
First look at RNA in L-configuration.
Acta Crystallogr D 60, 1-7
Betzel C, Singh TP, Genov N
Phospholipase A2.
Handbook of Metalloproteins 3, 677 - 691
Betzel C, Krauspenhaar R, Voelter W, Stoeva S Mikhailov A
Structure of misteltoe I in complex with lactose and galactose.
Biophys J 84, 356-357
Georgieva D, Rypniewski W, Perbandt M, Jain M, Genov N, Betzel C
Crystallisation and preliminary X-ray driffraction studies of a toxic phospholipase A2 from the venom of Vipera ammodytes meridionalis to a synthetic inhibitor.
Biochim Biophys Acta 1650, 1-3
Perbandt M, Tsai I-H, Fuchs A, Banumathi S, Rajashankar KR, Georgieva D, Kalkura N, Genov N, Betzel C
Structure of the heterodimewric neurotoxic Complex Daboiatoxin F (RV-4/RV-7) from the venom of Daboia russelli formosensis (Taiwan Viper) at 19Å Resolution.
Acta Crystallogr D 59, 1679-1687
Burmeister C, Perbandt M, Betzel C, Walter RD, Liebau E
Crystallization and preliminary X-ray diffraction studies of the glutathione S-transferase from Plasmodium falciparum.
Acta Crystallogr D 59, 1469-1471
Bruzzone S, Kunerth S, Zocchi E, De Flora A, Guse AH
Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors.
J Cell Biol 163, 837-845
Sternfeld L, Krause E, Guse AH, Schulz I
Hormonal control of ADP-ribosyl cyclase activity in pancreatic acinar cells from rats.
J Biol Chem 278, 33629-33636
Perbandt M, Guthöhrlein E, Rypniewski W, Idakieva K, Stoeva S, Voelter W, Genov N, Betzel C
The Structure of a Functional Unit from the Wall of a Gastropod Hemocyanin Offers a Possible Mechanism for Cooperativity.
Biochemistry-US 42, 6341-6346
Kunerth S, Mayr GW, Koch-Nolte F, Guse AH
Analysis of subcellular calcium signals in T-lymphocytes.
Cell Signal 15, 783-792
Wagner GK, Riley AM, Rosenberg HJ, Taylor CW, Guse AH, Potter BVL
Analogues of cyclic adenosine 5´-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction.
Nucleic Acids Res 3, 1-2
Wagner GK, Black S, Guse AH, Potter BVL
First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist.
Chem Commun 15, 1944-1945
Heitmann B, Maurer T, Weitzel JM, Strätling WH, Kalbitzer HR, Brunner E
Solution structure of the matrix attachment region-binding domain of chicken MeCP2.
Eur J Biochem 270, 3263-3270
Kumar J, Weber W, Munchau S, Yadav S, Singh SB, Saravanan K, Paramasivam M, Sharma S, Kaur P, Bhushan A, Srinivasan A, Betzel C, Singh TP
Crystal structure of human seminal diferric lactoferrin at 34 angstrom resolution.
Indian J Biochem Bio 40, 14-21
Nalaskowski MM, Bertsch U, Fanick W, Stockebrand MC, Schmale H, Mayr GW
Rat inositol 1,4,5-trisphosphate 3-kinase C is enzymatically specialized for basal cellular inositol trisphosphate phosphorylation and shuttles actively between nucleus and cytoplasm.
J Biol Chem 278, 19765-19776
Perbandt M, Barciszewska MZ, Betzel C, Erdmann VA, Barciszewski J
A critical role of water in the specific cleavage of the anticodon loop of some eukaryotic methionine initiator tRNAs.
Mol Biol Rep 30, 27-31
Georgieva DN, Genov N, Nikolav P, Alesksiev B, Rajashankar KR, Voelter W, Betzel C
Structure-function relationships in the neurotoxin Vipoxin from the venom of Vipera ammodytes meridionalis.
Spectrochim Acta A 59, 617-627
Rajashankar K, Bufe A, Weber W, Eschenburg S, Lindner B, Betzel C
Structure of the functional domain of the major grass-pollen allergen Phlp 5b.
Acta Crystallogr D 58, 1175-1181
Vallazza M, Banumathi S, Perbandt M, Moore K, DeLucas L, Betzel C, Erdmann VA
Crystallization and structure analysis of thermus flavus 5S rRNA helix B.
Acta Crystallogr D 58, 1700-1703
Krauspenhaar R, Rypniewski W, Kalkura N, Moore K, DeLucas L, Stoeva S, Mikhailov A, Voelter W, Betzel C
Crystallisation under microgravity of mistletoe lectin I from Viscum album with adenine monophosphate and the crystal structure at 19 angstrom resolution.
Acta Crystallogr D 58, 1704-1707
Chandra V, Jasti J, Kaur P, Dey S, Srinivasan A, Betzel C, Singh TP
Design of specific peptide inhibitors of phospholipase A(2): structure of a complex formed between Russell´s viper phospholipase A(2) and a designed peptide Leu-Ala-Ile-Tyr-Ser (LAIYS).
Acta Crystallogr D 58, 1813-1819
Stoeva S, Idakieva K, Betzel C, Genov N, Voelter W
Amino acid sequence and glycosylation of functional unit RtH2-e from Rapana thomasiana (gastropod) hemocyanin.
Arch Biochem Biophys 399, 149-158
Nalaskowski MM, Deschermeier C, Fanick W, Mayr GW
The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization.
Biochem J 366, 549-556
Guse AH, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey VC, Matsuda A, Mayr GW, Oppenheimer N, Schuber F, Potter BVL
Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.
Biochemistry-US 41, 6744-6751
Chandra V, Jasti J, Kaur P, Srinivasan A, Betzel C, Singh TP
Structural basis of phospholipase A(2) inhibition for the synthesis of prostaglandins by the plant alkaloid aristolochic acid from a 17 angstrom crystal structure.
Biochemistry-US 41, 10914-10919
Guthöhrlein E, Perbandt M, Rypniewsky W, Stoeva S, Voelter W, Genov N, Betzel C
Structure of a functional unit from the cylindrical wall of a gastropod hemocyanin-RtH2e from Rapana.
Biophys J 82, 1534-1534
Guse AH
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP): novel regulators of Ca2+ signaling and cell functions.
Curr Mol Med 2, 273-282
Friel J, Itoh K, Bergholz U, Jücker M, Stocking C, Harrison P, Ostertag W
Hierarchy of stroma-derived factors in supporting growth of stroma-dependent hemopoietic cells: Membrane-bound SCF is sufficient to confer stroma competence to epithelial cells.
Growth Factors 20, 35-51
Windhorst S, Frank E, Georgieva DN, Genov N, Buck F, Borowski P, Weber W
The major extracellular protease of the nosocomial pathogen Stenotrophomonas maltophilia - Characterization of the protein and molecular cloning of the gene.
J Biol Chem 277, 11042-11049
Zimmermann K, Ahrens K, Matthes S, Buerstedde JM, Strätling WH, Loc PV
Targeted disruption of the GAS41 gene encoding a putative transcription factor indicates that GAS41 is essential for cell viability.
J Biol Chem 277, 18626-18631
Schwarzmann N, Kunerth S, Weber K, Mayr GW, Guse AH
Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the t-cell receptor/CD3 complex.
J Biol Chem 277, 50636-50642
Chandra V, Jasti J, Kaur P, Dey S, Perbandt M, Srinivasan A, Betzel C, Singh TP
Crystal structure of a complex formed between a snake venom phospholipase A(2) and a potent peptide inhibitor Phe-Leu-Ser-Tyr-Lys at 18 A resolution.
J Biol Chem 277, 41079-41085
Chandra V, Jasti J, Kaur P, Betzel C, Srinivasan A, Singh TP
First structural evidence of a specific inhibition of phospholipase A(2) by alpha-tocopherol (vitamin E) and its implications in inflammation: crystal structure of the complex formed between phospholipase A(2) and alpha-tocopherol at 18 angstrom resoluti.
J Mol Biol 320, 215-222
Jeyaprakash AA, Rani PG, Reddy GB, Banumathi S, Betzel C, Sekar K, Surolia A, Vijayan M
Crystal structure of the jacalin-t-antigen complex and a comparative study of lectin-t-antigen complexes.
J Mol Biol 321, 637-645
Guse AH
The role of cADPR and NAADP in T cell Ca2+ signaling and activation in "cyclic ADP-ribose and NAADP: structures, metabolism and functions.
Kluwer Academic Publishers 301-318
Jücker M, Südel K, Horn S, Sickel M, Wegner W, Fiedler W, Feldman RA
Expression of a mutated form of the p85 alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin´s lymphoma-derived cell line (CO).
Leukemia 16, 894-901
Shlyapnikov SV, Lunin VV, Blagova EV, Abaturov LV, Perbandt M, Betzel C, Mikhailov AM
A comparative structure-function analysis and molecular mechanism of action of endonucleases from Serratia marcescens and Physarum polycephalum.
Russ J Bioorg Chem 28, 20-27
Nötzel C, Chandra V, Rajashankar RK, Singh TP, Aleksiev B, Genov N, Betzel C
Enzymatic Activity and Inhibition of the Neurotoxic Complex Vipoxin from the Venom of Vipera ammodytes meridionalis.
Z Naturforsch C 57, 1078-1083
Perbandt M, Vallazza M, Lippmann C, Betzel C, Erdmann VA
Structure of an RNA duplex with an unusual GC pair in wobble-like conformation at 16 A resolution.
Acta Crystallogr D 57, 219-224
Sharma S, Kumar P, Jabeen T, Bredehorst R, Vogel CW, Betzel C, Singh TP
Structural studies of the cobra venom factor: isolation, purification, crystallisation and preliminary crystallographic analysis.
Acta Crystallogr D 57, 596-598
Banumathi S, Rajashankar KR, Nötzel C, Aleksiev B, Singh TP, Genov N, Betzel C
Crystal structure of the neurotoxic complex vipoxin at 14 A resolution.
Acta Crystallogr D 57, 1552-1559
Perbandt M, Chandra V, Rajashankar KR, Idakieva K, Parvanova K, Rypniewski W, Stoeva S, Voelter W, Genov N, Betzel C
Preliminary x-ray diffraction studies of an external functional unit from the rapana thomasiana hemocyanin.
Acta Crystallogr D 57, 1663-1665
Chandra V, Kaur P, Jasti J, Betzel C, Singh TP
Regulation of a catalytic function by molecular association: structure of phospholipase A2 from Daboia russelli pulchella (DPLA2) at 19 A resolution 2.
Acta Crystallogr D 57, 1793-1798
Schweitzer K, Mayr GW, Guse AH
Assay for ADP-ribosyl cyclase by reverse-phase HPLC.
Anal Biochem 299, 218-226
Georgieva DN, Stoeva S, Voelter W, Genov N, Betzel C
Differences in the specificities of the highly alkalophilic proteinases savinase and esperase imposed by changes in the rigidity and geometry of the substrate binding sites.
Arch Biochem Biophys 387, 197-201
Stoeva S, Franz M, Maier T, Wacker R, Krauspenhaar R, Guthöhrlein E, Betzel C, Voelter W
Primary structure, isoforms and molecular modelling of a chitin-binding mistletoe lectin.
Arch Biochem Biophys 392, 23-31
Betzel C, Gourinath S, Kumar P, Kaur P, Perbandt M, Eschenburg S, Singh TP
Structure of a serine protease proteinase K from Tritirachium album limber at 098 A resolution.
Biochemistry-US 40, 3080-3088
Betzel C, Banumathi S, Rajashankar KR, Genov N
Structure of the neurotoxic complex Vipoxin at 14 Angstrom resolution: a unique example of evolution of the catalytic and toxic phospholipase A2 function into inhibitory and nontoxic ones.
Biophys J 80, 1691-1691
Horn S, Fehse B, Endl E, Weck M, Mayr GW, Jücker M
Restoration of SHIP activity in a human leukemia cell line leads to a differential downregulation of the constitutively activated PI3-kinase/Akt/GSK30 signaling pathway and G 1 cell cycle arrest.
Blood 98, 1222-1222
Schöttelndreier H, Potter BVL, Mayr GW, Guse AH
Mechanisms involved in a6ß1-integrin-mediated Ca2+ signalling Cell.
Cell Signal 13, 895-899
Konareva NV, Gabdulkhakov AG, Eschenburg S, Stoeva S, Popov AN, Krauspenhaar R, Andrianova ME, Savochkina Y, Agaov II, Tonevitskii AG, Kornev AN, Kornilov VV, Zaitsev VNM, Voelter W, Betzel C, Nikonov SV, Vainshtein BK, Mikhailov AM
Topology of the polypeptide chain in the complex of agglutinin from castor bean seeds with beta-D-galactose in the crystalline state.
Crystallogr Rep 46, 792-800
Georgieva DN, Stoeva S, Voelter W, Genov N, Betzel C
Substrate specificity of the highly alkalophilic bacterial proteinase esperase: relation to the x-ray structure.
Curr Microbiol 42, 368-371
Pfister M, Ogilvie A, da Silva CP, Grahnert A, Guse AH, Hauschildt S
NAD degradation and regulation of CD38 expression by human monocytes/macrophages.
Eur J Biochem 268, 5601-5608
Yang SN, Yu J, Mayr GW, Hofmann F, Larsson O, Berggren PO
Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.
Faseb J 15, 1753-1763
Gourinath S, Degenhardt M, Eschenburg S, Moore K, DeLucas LJ, Betzel C, Singh TP
Mercury induced modifications in the stereochemistry of the active site through Cyc-73 in a serine protease-crystal structure of the complex of a partially modified porteinase K with mercury at 18 A resolution 2.
Indian J Biochem Bio 38, 298-302
Guse AH, Tsygankov AY, Weber K, Mayr GW
Transient tyrosine phosphorylation of human ryanodine receptor upon T cell stimulation.
J Biol Chem 276, 34722-34727
Betzel C
X-ray structure analysis of food allergens.
J Chromatogr B 756, 179-181
Sharma S, Kumar P, Betzel C, Singh TP
Structure and function of proteins involved in milk allergies.
J Chromatogr B 756, 183-187
Vallazza M, Lippmann C, Perbandt M, Betzel C, Bald R, Erdmann VA
Crystallisation and x-ray diffraction data of thermus flavus 5S rRNA helices 2.
J Cryst Growth 232, 340-351
Perbandt M, Chandra V, Idakieva K, Parvanova K, Rypniewski W, Stoeva S, Voelter W, Genov N, Betzel C
Crystallization, preliminary X-ray analysis and amino acid sequence studies of an "external" functional unit from the Rapana thomasiana grosse (mollusc, gastropod) hemocyanin.
J Cryst Growth 232, 353-360
Barciszewska MZ, Rapp G, Betzel C, Erdmann VA, Barciszewska J
Structural changes of tRNA and 5S rRNA induced with magnesium and visualized with synchrotron mediated hydroxyl radical cleavage.
Mol Biol Rep 28, 103-110
Yu F, Zingler N, Schumann G, Strätling WH
Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription.
Nucleic Acids Res 29, 4493-4501
Singh RK, Gourinath S, Sharma S, Roy I, Gupta MN, Betzel C, Singh TP
Enhancement of enzyme activity through three-phase partitoning: crystal structure of a modified serine proteinase at 15 resolution.
Protein Eng 14, 307-313
Shlyapnikov SV, Lunin VV, Blagova EV, Perbandt M, Betzel C, Mikhailov AM
X-ray analysis of the magnesium-containing endonuclease from Serratio marcescens.
Russ J Bioorg Chem 27, 370-377
Shlyapnikov SV, Lunin VV, Blagova EV, Perbandt M, Betzel C, Abaturov LV, Mikhailov AM
Structure and functional role of protein-bonded magnesium-water cluster of the endonuclease from Serratia marcescens.
Russ J Inorg Chem 46, 1690-1696
Gourinath S, Alam N, Srinivasan A, Betzel C, Singh TP
Structure of the bifunctional inhibitor of trypsin and alpha-amylase from ragi seeds at 22 A resolution.
Acta Crystallogr D 56, 287-293
Lorenz S, Perbandt M, Lippmann C, Moore K, DeLucas LJ, Betzel C, Erdmann VA
Crystallization of engineered thermus flavus 5S rRNA under earth and microgravity conditions.
Acta Crystallogr D 56, 498-500
Shlyapnikov SV, Lunin VV, Perbandt M, Polyakov KM, Lunin VY, Levdikov VM, Betzel C, Mikhailov AM
Atomic structure of the serratia marcescens endonuclease at 11 A resolution and the enzyme reaction mechanism.
Acta Crystallogr D 56, 567-572
da Silva CP, Guse AH
Intracellular Ca2+ release mechanisms: multiple pathways having multiple functions within the same cell type?.
BBA-Mol Cell Res 1498, 122-133
Funari SD, Betzel C, Chandra V, Singh TP, Genov M
Dynamic light scattering (DLS) in protein solutions.
Biophys J 78, 1731-1731
Betzel C, Genov N, Chandra V, Singh TP
PLA2 inhibitor complexes at high resolution.
Biophys J 78, 2443-2443
Laussmann T, Pikzack C, Thiel U, Mayr GW, Vogel G
Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium.
Eur J Biochem 267, 2447-2451
Hilz H, Graefen M, Noldus J, Hammerer P, Knabbe C, Huland E, Huland H
Advanced prostate cancer is associated with a decrease in serum luteinizing hormone.
Eur Urol 38, 243-249
Gallon JR, Cheng JJ, Dougherty LJ, Gallon VA, Hilz H, Pederson DM, Richards HM, Ruggeberg S, Smith CJ
A novel covalent modification of nitrogenase in a cyanobacterium.
FEBS Lett 468, 231-233
Bertsch U, Deschermeier C, Fanick W, Girkontaite I, Hillemeier K, Johnen H, Weglöhner W, Emmrich F, Mayr, GW
The second messenger binding site of inositol 1,4,5-trisphosphate 3-kinase is centred in the catalytic domain and related to the inositol trisphosphate receptor site.
J Biol Chem 275, 1557-1564
Weernink PAO, Schulte P, Guo YJ, Wetzel J, Amano M, Kaibuchi K, Haverland S, Voss M, Schmidt M, Mayr GW, Jakobs KH
Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.
J Biol Chem 275, 10168-10174
Funari SS, Rapp G, Perbandt M, Dierks K, Vallazza M, Betzel C, Erdmann VA, Svergun DI
Structure of free thermus flavus 5 S rRNA at 13 nm resolution from synchrotron x-ray solution scattering.
J Biol Chem 275, 31283-31288
Brunner E, Weitzel J, Heitmann B, Maurer T, Strätling WH, Kalbitzer HR
Letter to the Editor: Sequence-specific H-1, C-13, and N-15 assignments of the MAR-binding domain of chicken MeCP2/ARBP.
J Biomol NMR 17, 175-176
Berg I, Potter BVL, Mayr GW, Guse AH
Nicotinic acid adenine dinucleotide phosphate (NAADP+) is an essential regulator of T-lymphocyte Ca2+-signaling.
J Cell Biol 150, 581-588
Eschenburg S, Degenhardt M, Moore K, DeLucas LJ, Peters K, Fittkau S, Weber W, Betzel C
Crystallization of proteinase K complexed with substrate analogue peptides on US space missions STS-91 and STS-95.
J Cryst Growth 208, 657-664
Guse AH
Cyclic ADP-ribose.
J Mol Med-JMM 78, 26-35
Guse AH
The calcium mobilising second messenger cyclic ADP-ribose in calcium: the molecular basis of calcium action in biology and medicine.
Kluwer Academic Publishers , 109-128
Reichwald K, Thiesen J, Wiehe T, Weitzel J, Strätling WH, Kioschis P, Poustka A, Rosenthal A, Platzer M
Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.
Mamm Genome 11, 182-190
Yu F, Thiesen J, Strätling WH
Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2.
Nucleic Acids Res 28, 2201-2206
Georgieva DN, Betzel C, Aleksiev B, Genov N
Spectroscopic investigation of calcium binding sites in the neurotoxin Vipoxin and ist components-relation with the x-ray structure.
Spectrochim Acta A 56, 2811-2816
Rajashankar KR, Tsai IH, Betzel C
Crystallization and preliminary x-ray diffraction studies of the neurotoxic, heterodimeric phospholipyse A2 from the Taiwan viper (vipera russelli formosensis.
Acta Crystallogr D 55, 1064-1065
Sharma S, Karthikeyan S, Betzel C, Singh TP
Isolation, purification, crystallization and preliminary x-ray analyisis of beta 1-bungarotoxin from bungarus caeruleus (indian common krait).
Acta Crystallogr D 55, 1093-1094
Krauspenhaar R, Eschenburg S, Perbandt M, Kornilov V, Konareva N, Mikailova I, Stoeva S, Wacker R, Maier T, Singh T, Mikhailov A, Voelter W, Betzel C
Crystal structure of mistletoe lectin I from viscum album.
Biochem Bioph Res Co 257, 13418-13424
Gehrmann T, Gülkan H, Suer S, Herberg FW, Balla A, Vereb G, Mayr GW, Heilmeyer LMG
Functional expression and characterization of a new human phosphatidylinositol 4-kinase PIK230.
Biochim Biophys Acta 1437, 341-356
Funari SS, Svergun D, Rapp G, Betzel C, Perbandt M, Erdman VA
Small angle X-ray scattering study on the ribosomal 5S RNA.
Biophys J 76, 315-315
Hohenegger M, Berg I, Weigl L, Mayr GW, Potter BVL, Guse AH
Pharmacological activation of the ryanodine receptor in Jurkat T- lymphocytes.
Brit J Pharmacol 128, 1235-1240
Tanny JC, Dowd GJ, Huang J, Hilz H, Moazed D
An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing.
Cell 99, 735-745
Betzel C, Genov N, Rajashankar KR, Singh TP
Modulation of phospholipase A(2) activity generated by molecular evolution.
Cell Mol Life Sci 56, 384-397
Guse AH
Cyclic ADP-ribose: a novel Ca2+-mobilizing second messenger.
Cell Signal 11, 309-316
Schöttelndreier H, Mayr GW, Guse AH
Beta 1-integrins mediate Ca2+-signalling and T cell spreading via divergent pathways.
Cell Signal 11, 611-619
Vernoslova EA, Konareva NV, Mikhailov AM, Popov AN, Zaitsev VN, Agapov II, Tonevitskii AG, Kirpichnikov MP, Lentzen H, Kornev AN, Kornilov VV, Pfuller U, Betzel C, Mikhailova IV, Voelter W
X-ray diffraction study of native MLI from Viscum album (mistletoe) at a 35 angstrom resolution.
Cristallogr Rep 44, 582-588
Strätling WH, Yu F
Origin and roles of nuclear matrix proteins Specific functions of the MAR-binding protein MeCP2/ARBP.
Crit Rev Eukar Gene 9, 311-318
Hilz H, Noldus J, Hammerer P, Buck F, Luck M, Huland H
Molecular heterogeneity of free PSA in sera of patients with benign and malignant prostate tumors.
Eur Urol 36, 286-292
Bertsch U, Haefs M, Möller M, Deschermeier C, Fanick W, Kitzerow A, Ozaki S, Meyer HE, Mayr GW
A novel A-isoform-like inositol 1,4,5-trisphosphate 3-kinase from chicken erythrocytes exhibits alternative splicing and conservation of intron positions between vertebrates and invertebrates.
Gene 228, 61-71
Mate MJ, Zamocky M, Nykyri LM, Herzog C, Alzari PM, Betzel C, Koller F, Fita I
Structure of catalase-A from saccharomyces cerevisiae.
J Mol Biol 286, 135-149
Guse AH, Kaiser T, Albert C, Mayr GW
Analysis of inositol phospahtes from biological sources by metal-dye detection HPLC in: Proceedings of the workshop on plajnt phytate and phytases.
Kluver-Academic Press , -
Shliapnikov SV, Blagova EV, Levdikov VM, Lunin VI, Lunin VV, Mikhailov AM, Betzel C, Rajashankar KR, Perbandt M
The extracellular endocuclease of Serratia marcescens II Active site Amino acid residues and a hypothetical mechanism of enzyme functioning.
Mol Biol (Mosk) 33, 398-404
Guse AH, da Silva CP, Berg I, Skapenko AL, Weber K, Heyer P, Hoheneger M, Ashamu GA, Schulze-Koops H, Potter BVL, Mayr GW
Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose.
Nature 398, 70-73
Phi-Van L, Strätling WH
An origin of bidirectional DNA replication is located within a CpG island at the 3 ' end of the chicken lysozyme gene.
Nucleic Acids Res 27, 3009-3017
Georgieva DN, Genov N, Rajashankar KR, Aleksiev B, Betzel C
Spectroscopic investigation of phenolic groups ionization in the vipoxin neurotoxic phospholipase A2: comparison with the x-ray structure in the region of the tyrosyl residues.
Spectrochim Acta A 55, 239-244
Georgieva DN, Nikolov P, Ivanova V, Gusterova A, Betzel C
Fluorescence properties of Savinase (R): the x-ray structure in the region of the tryptophyl residues.
Spectrochim Acta A 55, 2309-2319
Degenhardt M, Weber W, Eschenburg S, Dierks K, Funari SS, Rapp G, Betzel C
Crystallization and preliminary X-ray crystallographic analysis of the EGF receptor ectodomain.
Acta Crystallogr D 54, 999-1001
Eschenburg S, Krauspenhaar R, Mikhailov A, Stoeva S, Betzel C, Voelter W
Primary structure and molecular modeling of mistletoe lectin I from Viscum album.
Biochem Bioph Res Co 247, 367-372
Hansen PE, Zhang W, Lauritzen C, Bjorn S, Petersen LC, Norris K, Olsen OH, Betzel C
C-13 NMR, x-ray, and differential scanning calorimetry investigations of truncated BPTI (aprotinin) analogues.
Biochemistry-US 37, 3645-3653
Funari SS, Baboi N, Rapp G, Betzel C
Mixed POPE and surfactant model membranes.
Biophys J 74, 28-28
Meyer J, Jücker M, Ostertag W, Stocking C
Carboxyl-truncated STAT5 beta is generated by a nucleus-associated serine protease in early hematopoietic progenitors.
Blood 91, 1901-1908
Zorb C, Brunner KD, Perbandt M, Betzel C, Wagner G
Cloning, recombinant expression and characterization of wild type-105-Trp-calmodulin of the green alga Mougeotia scalaris.
Botanica acta 111, 346-353
Guse AH
Ca2+-signaling in t-lymphocytes - invited review.
Crit Rev Immunol 18, 419-448
Eschenburg S, Genov N, Peters K, Fittkau S, Stoeva S, Wilson KS, Betzel C
Crystal structure of subtilisin DY, a random mutant of subtilisin Carlsberg.
Eur J Biochem 257, 309-318
Perbandt M, Nolte A, Lorenz S, Bald R, Betzel C, Erdmann VA
Crystal structure of domain E of Thermus flavus 5S rRNA: a helical RNA structure including a hairpin loop.
FEBS Lett 429, 211-215
da Silva CP, Schweitzer K, Heyer P, Malavasi F, Mayr GW, Guse AH
Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-signalling activity of cyclic ADP-ribose in T-lymphocytes are not functionally related.
FEBS Lett 439, 291-296
Phi-van L, Sellke C, von Bodenhausen A, Strätling WH
An initiation zone of chromosomal DNA replication at the chicken lysozyme gene locus.
J Biol Chem 273, 18300-18307
da Silva CP, Potter BVL, Mayr GW, Guse AH
Quantification of intracellular levels of cyclic ADP-ribose by high-performance-liquid chromatography.
J Chromatogr B 707, 43-50
Jun KS, Choi G, Yang S-G, Kim D, Kang N-G, Choi KY, Kim H, Chan GCK, Storm DR, Albert C, Mayr GW, Lee C-J, Shin H-S
Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice.
Learn Memory 5, 317-330
Hamann S, Strätling WH
Specific binding of Drosophila nuclear protein PEP (protein on ecdysone puffs) to hsp70 DNA and RNA.
Nucleic Acids Res 26, 4108-4115
Singh TP, Sharma S, Karthikeyan S, Betzel C, Bhatia KL
Crystal structure of a complex formed between proteolytically-generated lactoferrin fragment and proteinase K.
Proteins 33, 30-38
Georgieva DN, Nikolov P, Betzel C
Steady-state and time-resolved fluorescence of Esperase (R): comparison with the x-ray structure in the region of the two tryptophans.
Spectrochim Acta A 54, 1109-1116
Genov N, Dolashka P, Aleksiev B, Mancheva I, Rajashankar KR, Betzel C
Spectroscopic properties and stability of the neurotoxic complex Vipoxin and its components.
Spectrochim Acta A 54, 1117-1125
Müller U, Weber W, Hoffmann A, Franke S, Lange R & Vieths S
Commercial soybean lecithins: a source of hidden allergens?.
Z Lebensm Unters Forsch 207, 341-351
Hilz, H
ADP-RIBOSE - A historical overview.
Adv Exp Med Biol 419, 15-24
Guse AH, da Silva CP, Potter BVL, Mayr GW
Ca2+-signalling in human T-lymphocytes: potential roles for cyclic ADP-ribose and 2"-phospho-cyclic ADP-ribose in: "ADP-ribosylation in animal tissues:.
Adv Exp Med Biol 419, 431-436
Bandyopadhyay U, Kaiser T, Rudolph MT, Schultz C, Guse AH, Mayr GW
Vicinal thiols are involved in inositol 1,2,3,5,6-pentakisphosphate 5-phosphatase activity from fetal calf thymus.
Biochem Bioph Res Co 240, 146-149
Weitzel J, Strätling WH
The case of chicken ARBP reinforces the importance of prescreening of several libraries for cDNA cloning.
Biochem J 321, 261-262
Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy KK, Falck JR, Bröcker M, Shears SB, Mayr GW
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
Biochem J 327, 553-560
Laggner P, Prassl R, Saxena A, Nigon F, Sara M, Eschenburg S, Betzel C, Chapman JM
Crystallization and preliminary X-ray crystallography of a low density lipoprotein from human plasma.
Biophys J 72, 3-3
Guse AH and Mayr GW
Zyclische ADP-Ribose: ein potentieller second messenger in der Regulation der intrazellulären ca2+-Konzentration.
Biospektrum 4.97, 25-28
Jücker M, Schiffer CA, Feldman RA
A tyrosine phosphorylated protein of 140 kD is constitutively associated with the phosphotyrosine binding domain of Shc and the SH3 domains of Grb2 in acute myeloid leukemia cells.
Blood 89, 2024-2035
Guse AH, de Wit C, Klokow T, Schweitzer K, Mayr GW
Unique properties of the capacitaitve Ca2+-entry antagonist LU52396: Its inhibitory activity depends on the activation state of the cells.
Cell Calcium 22, 91-97
Broecker M, Mayr GW, Derwahl M
Suppression of thyrotropin receptor-G-protein-phospholipase C coupling by activation of protein kinase C in thyroid carcinoma cells.
Endocrinology 138/9, 3787-3796
Guse AH, da Silva CP, Weber K, Armah CN, Ashamu GA, Schulze C, Potter BVL, Mayr GW, Hilz H
1-(5-Phospho-beta-D-ribosyl)2´-phosphoadenosine 5´-phosphate cyclic anhydride induced Ca2+ release in human T-cell lines.
Eur J Biochem 245, 411-417
Hamann S, Strätling WH
Purification and characterization of an scs' binding protein.
Eur J Cell Biol 72, 242-242
Weitzel JM, Strätling WH
The MAR binding domain of chicken attachment region binding protein (cARBP).
Eur J Cell Biol 72, 243-243
Perbandt M, Wilson JC, Eschenburg S, Mancheva I, Aleksiev B, Genov N, Willingmann P, Weber W, Singh TP, Betzel C
Crystal structure of vipoxin at 20 A an example of regulation of a toxic function gererated by molecular evolution.
FEBS Lett 412, 573-577
de Weerth A, von Schrenck T, Pace A, Sievers M, Guse AH, Wolf G, Schulz M, Greten H
The effect of gastrin on murine mesangium cells (MMC): Kinetics of proliferation and effects on intracellular calcium concentration (Ca2+).
Gastroenterology 112, 1142-1142
Guse AH, Berg I, da Silva CP, Potter BVL, Mayr GW
Ca2+-entry induced by cyclic ADP-ribose in intact T-lymphocytes.
J Biol Chem 272, 8546-8550
Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA
The fes protein-tyrosine kinase phosphoylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling.
J Biol Chem 272, 2104-2109
Weismann M, Guse AH, Sorokin L, Bröker B, Frieser M, Hallmann R, Mayr GW
Integrin-mediated intracellular Ca2+ signaling in Jurkat T lymphocytes.
J Immunol 158, 1618-1627
Rudolf MT, Kaiser T, Guse AH, Mayr GW, Schultz C
Synthesis and metabolism of the myo-inositol pentakisphosphates.
Liebigs Ann-Recl 9, 1861-1869
Weitzel JM, Buhrmester H and Strätling WH
Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG binding portein MeCP2.
Mol Cell Biol 17, 5656-5666
Larsson O, Barker CJ, Sjötholm A, Carlqvist H, Michell RH, Bertorello A, Nilsson T, Honkanen RE, Mayr GW, Zwiller J, Berggren P-O
Inhibition of phosphatases and invreased ca2+ channel activity by inositol hexakisphosphate.
Science 278, 471-474
Dauter Z, Betzel C, Genov N, Wilson KS.
The complex between mesentericopeptidase and eglin-C.
Adv Exp Med Biol 379, 1-4
Singh TP, Padmanabhan B, Narula P, Saxena AK, Betzel C, Sharma P, Dey S
Design of specific peptide structures and subtilisin enzyme inhibitors using alpha,beta-dehydro-residues.
Adv Exp Med Biol 379, 11-20
Pfeffer-Hennig S, Dauter Z, Hennig M, Hohne W, Wilson K, Betzel C
Three dimensional structure of the antibiotic bacitracin A complexed to two different subtilisin proteases: novel mode of enzyme inhibition.
Adv Exp Med Biol 379, 29-41
Betzel C, Klupsch S, Branner S, Wilson KS
Crystal structures of the alkaline proteases savinase and esperase from Bacillus lentus.
Adv Exp Med Biol 379, 49-61
Genov N, Nikolov P, Betzel C, Wilson K
Fluorescence decay of tryptophans in serine proteinases from microorganisms: relation to X-ray models.
Adv Exp Med Biol 379, 141-145
Lange G, Betzel C, Wilson K, Branner S
pH dependence of the catalytic activity of a subtilisin-like proteinase.
Adv Exp Med Biol 379, 229-233
Olsen OH, Pedersen JT, Betzel C, Eschenburg S, Branner S, Hastrup S
An investigation of the savinase water channel: implications of cavity mutations.
Adv Exp Med Biol 379, 235-41
Saxena AK, Singh TP, Peters K, Fittkau S, Visanji M, Wilson KS, Betzel C Structure of a ternary complex of proteinase K, mercury, and a substrate-analogue hexa-peptide at 2.2 A resolution.
Proteins 25, 195-201
Bufe A, Betzel C, Schramm G, Petersen A, Becker WM, Schlaak M, Perbandt M, Dauter Z, Weber W
Crystallization and preliminary diffraction data of a major pollen allergen. Crystal growth separates a low molecular weight form with elevated biological activity.
J Biol Chem 271, 27193-27196
Prassl R, Chapman JM, Nigon F, Sara M, Eschenburg S, Betzel C, Saxena A, Laggner P
Crystallization and preliminary X-ray analysis of a low density lipoprotein from human plasma.
J Biol Chem 271, 28731-28733
Saxena AK, Singh TP, Peters K, Fittkau S, Betzel C
Strategy to design peptide inhibitors: structure of a complex of proteinase K with a designed octapeptide inhibitor N-Ac-Pro-Ala-Pro-Phe-DAla-Ala-Ala-Ala-NH2 at 2.5 A resolution.
Protein Sci 5, 2453-2458
Hempel K, Strätling WH
The chicken lysozyme gene 5' MAR and the Drosophila histone SAR are electroelutable from encapsulated and digested nuclei.
Journal of Cell Science 109, 1459-1469
Phi-Van L, Strätling WH
Dissection of the ability of the chicken lysozyme gene 5' MAR to stimulate transgene expression and to dampen position effects.
Biochemistry-US 35, 10735-10742
Sellke C, Hanhua X, Strätling WH and Phi-Van L
DNA replication occurs at the nuclear matrix.
J Anim Breed and Genet 113, 237-241
Borowski P, Kornetzky L, Heiland M, Roloff S, Weber W, Laufs R
Characterization of the C-terminal domain of ras-GTPase-activating protein (ras-GAP) as substrate for epidermal growth factor receptor and p60 c-src kinase.
Biochem Mol Biol Int 39, 635-46
Bufe A, Betzel C, Schramm G, Petersen A, Becker WM, Schlaak M, Perbandt M, Dauter Z and Weber W
Crystallization and preliminary diffraction data of a major pollen allergen: Crystal growth separates a low molecular weight form with elevated biological activity.
J Biol Chem 271, 27193-27196
Guse AH, da Silva CP, Weber K, Ashamu GA, Potter BVL, Mayr GW
Regulation of cyclic ADP-ribose-induced Ca2+-release by Mg2+ and inorganic phosphate.
J Biol Chem 271, 23946-23954
Simbula-Rosenthal CM, Rosenthal DS, Hilz H, Hickey R, Malkas L, Applegren N, Wu Y, Bers G, Smulson ME
The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex.
Biochemistry-US 35, 11622-11633
Genov N, Filippi B, Dolashka P, Wilson KS, Betzel C
Stability of subtilisins and related proteinases (subtilases).
Int J Pept Protein Res 45, 391-400
Bravo J, Verdaguer N, Tormo J, Betzel C, Switala J, Loewen PC, Fita I.
Crystal structure of catalase HPII from Escherichia coli.
Structure 3, 491-502
Nolte A, Klussman S, Lorenz S, Bald R, Betzel C, Dauter Z, Wilson K, Furste JP, Erdmann VA.
Crystallization and preliminary diffraction studies of the structural domain E of Thermus flavus 5S rRNA.
FEBS Lett 374, 292-294
Hartung E, Rübsam B, Koob M, Mayr GW
1,4,5-IP3: A further diagnostic indicator for malignant hyperthermia susceptibility.
Min Anest 60, 79-84
Schrenzel J, Demaurex N, Foti M, Van Delden C, Jaquet J, Mayr GW, Lew DP, Krause KH
Highly cooperative Ca2+-elevations in response to Ins(1,4,5)P3 microperfusion through a pach-clamp pipette.
Biophys J 69, 2375-2391
Guse AH, Goldwich A, Weber K, Mayr GW
Non-radioactive, isomer-specific inositol phosphate mass determinations: micro metal-dye detection-HPLC strongly improves speed and sensitivity of analyses from cells and micro-enzyme assays.
J Chromatogr B 672, 189-198
Guse AH, da Silva CP, Emmrich F, Ashamu GA, Potter BVL, Mayr GW
Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+-release in T-lymphocyte cell lines.
J Immunol 155, 3353-3359
Altrichter J, Guse AH, Resch K, Daeron M, Hückel C
Phosphatidylinositol hydrolysis and an increase in Ca2+ concentration in the signal-transduction process triggered by murine FCgR III are not required for protein kinase C translocation.
Eur J Biochem 228, 587-595
Guse AH
Regulation intrazellulärer Ca2+-Signale in T-Lymphocyten.
BioSpektrum 6, 47-48
Banyeux F, Bertsch U, Kalbach CE, van der Vies SM, Soll J, Gatenby AA
Spinach chloroplast cpn21 co-chaperonin possesses two functional domains fused together in a toroidal structure and exhibits nucleotide-dependent binding to plastid chaperonin 60.
J Biol Chem 270, 10695-10702
Hilz, H
Molekulare Formen des PSA und ihre klinische Signifikanz.
Urologie [A] 34, 275-282
Weber B, Weber W, Buck F, Hilz H.
Isolation of the myc Transcription Factor Nucleoside Diphosphate Kinase and the Multifunctional Enzyme Glyceraldyhyde-3-phosphate Dehydrogenase by cAMP Affinity Chromatography
Int J Biochem Cell Biol 27, 215-224
Bertsch U, Soll J
Functional analysis of isolated cpn10 domains and conserved amino acid residues in spinach chloroplast co-chaperonin by site directed mutagenesis.
Plant Mol Biol 29, 1039-55
Weglöhner W, Kauschmann A, Subramanian AR
Evolution of the NH2- and COOH-terminal extensions of chloroplast ribosomal protein S18.
Biochem Mol Biol Int 36, 265-273
Buhrmester H, von Kries J P, Strätling WH
Nuclear matrix protein ARBP recognizes a novel DNA sequence motif with high affinity.
Biochemistry 34, 4108-4117
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Lange G, Betzel C, Branner S, Wilson KS
Crystallographic studies of Savinase, a subtilisin-like proteinase, at pH 10.5.
Eur J Biochem 224, 507-18.
Betzel C, Lorenz S, Furste JP, Bald R, Zhang M, Schneider TR, Wilson KS, Erdmann VA
Crystal structure of domain A of Thermus flavus 5S rRNA and the contribution of water molecules to its structure.
FEBS Lett 351, 159-164
Weber W, Wenisch E, Gunther N, Marnitz U, Betzel C, Righetti PG.
Protein microheterogeneity and crystal habits: the case of epidermal growth factor receptor isoforms as isolated in a multicompartment electrolyzer with isoelectric membranes.
J Chromatogr A 679, 181-189
Pedersen JT, Olsen OH, Betzel C, Eschenburg S, Branner S, Hastrup S
Cavity mutants of Savinase. Crystal structures and differential scanning calorimetry experiments give hints of the function of the buried water molecules in subtilisins.
J Mol Biol 242(3), 193-202
Gessler K, Krauss N, Steiner T, Betzel C, Sandmann C, Saenger W
Crystal structure of beta-D-cellotetraose hemihydrate with implications for the structure of cellulose II.
Science 266, 1027-1029
DeLisle S, Parys J, Radenberg T, Wintermantel MR, Pittet D, Welsh MJ, Mayr GW
Second messenger specificity of the inositol tris-phos-phate receptor: reappraisal based on novel inositol phosphates.
Am J Physiol 266 (Cell Physiol. 35) C 429-C436
Dryer AL, Van der Kaay J, Mayr GW, Van Haastert PJM
Role of phospholipase C in Dictyostelium. Formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.
EMBO J 13, 1601-1609
Nürnberg B, Spicher K, Harhammer R, Bosserhoff A, Frank R, Hilz H und Schultz G
Purification of a novel G-protein a0-subtype from mammalian brain.
Biochem J 300, 387-394
Dürner J, Böhm I, Hilz H, Böger P
Posttranslational modification of nitrogenase. Differences between the purple bacterium Rhodospirillum rubrum and the cyanobacterium Anabaena rariabilis.
Eur J Biochem 220, 125-130
von Kries J P, Rosorius O, Buhrmester H, Strätling WH
Biochemical properties of attachment region binding protein ARBP.
FEBS Lett 342, 185-188
von Kries J P, Buck F, Strätling WH
Chicken MAR binding protein p120 is identical to human heterogeneous nuclear ribonucleoprotein (hnRNP) U.
Nucleic Acids Res 22, 1215-1220
Ahne B, Strätling WH
Characterization of a myeloid-specific enahncer of the chicken lysozyme gene. A major role for an Ets transcription factor-binding site.
J Biol Chem 269, 17794-17801
Betzel C, Günther N, Poll S, Moore K, DeLucas LJ, Bugg CE, Weber W Crystallization of the EGF receptor ectodomain on US Space Mission STS 47. Microgravity Science and Technology 7, 242-5
Weber W, Wenisch E, Günther N, Marnitz U, Betzel C, Righetti PG
Protein microheterogeneity and crystal habits: the case of epidermal growth fact or receptor isoforms as isolated in a multicompartment electrolyzer with isoelec tric membranes.
J Chromatogr A 679, 181-9
Henning M, Visanji M, Weber W, Janczikowski H, Plaas-Link A, Betzel C
COSIMA-protein crystal grwoth facility for automatic processing on unmanned satellites.
J Cryst Growth 135, 513-22
Borowski P, Medem S, Laufs R, Weber W
Regulation of epidermal growth factor receptor kinase by polyions.
J Biochem 115, 825-29
da Silva CP, Emmrich F, Guse AH
Adriamycin inhibits inositol 1,4,5-triphosphate 3-kinase in vitro and blocks formation of inositol 1,3,4,5-tetrakisphosphate in stimulated Jurkat T cells. Does inositol 1,3,4,5-tetrakiphosphate play a role in Ca2+-entry?
J Biol Chem 269, 12521-12526
Guse AH, Roth E, Emmrich F
Ca++-release and Ca2+-entry induced by rapid cytosolic alkalinization in Jurkat T-lymphocytes.
Biochem J 301, 83-88
Maria A. Brehm, Tobias M. H. Schenk, Xuefei Zhou, Werner
Fanick,
Hongying Ling, Sabine Windhorst, Marcus M. Nalaskowski, Georg W. Mayr
