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Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells. Brundert M, Heeren J, Merkel M, Carambia A, Herkel J, Groitl P, Dobner T, Ramakrishnan R, Moore KJ, Rinninger F.J Lipid Res. 2011 Apr;52(4):745-58. Epub 2011 Jan 9. PubMed PMID: 21217164. ...Abstract
Energy, brown adipose tissue, obesity. Merkel M, Heeren J. Dtsch Med Wochenschr. 2011 Mar;136(11):548-550. Epub 2011 Mar 8. German. PubMed PMID:21387214. ...full text article
Brown adipose tissue activity controls triglyceride clearance. Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG,Tromsdorf UI, Weller H, Waurisch C, Eychmüller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J.Nat Med. 2011 Feb;17(2):200-5. Epub 2011 Jan 23. PubMed PMID: 21258337. ...Abstract
Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo. Prawitt J, Beil FT, Marshall RP, Bartelt A, Ruether W, Heeren J, Amling M, Staels B, Niemeier A. Bone. 2011 Feb 1;48(2):339-46. Epub 2010 Sep 15. ...Abstract
PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication. Cuchet D, Sykes A, Nicolas A, Orr A, Murray J, Sirma H, Heeren J, Bartelt A, Everett RD. J Cell Sci. 2011 Jan 15;124(Pt 2):280-91. Epub 2010 Dec 20.PubMed PMID: 21172801; PubMed Central PMCID: PMC3010193. ...Abstract
Studienbewerberauswahl – Probates Mittel gegen den Ärztemangel? J. Hissbach, W. Hampe (2011). Arzt und Krankenhaus 2: 42-44
Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes. Kotzka J, Knebel B, Avci H, Jacob S, Nitzgen U, Jockenhovel F, Heeren J, Haas J, Muller-Wieland D. Atherosclerosis. 2010 Nov;213(1):156-65. Epub 2010 Aug 19. ...Abstarct
Hypertriglyceridemia in obese subjects: caused by reduced apolipoprotein A5 plasma levels? Heeren J, Merkel M. Atherosclerosis. 2010 Oct;212(2):386-7. Epub 2010 Jun 30. ...Abstract
Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity. Bartelt A, Beil FT, Schinke T, Roeser K, Ruether W, Heeren J, Niemeier A. Bone. 2010 Oct;47(4):736-45. Epub 2010 Jul 12. ...Abstract
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Kjolby M, Andersen OM, Breiderhoff T, Fjorback AW, Pedersen KM, Madsen P, Jansen P, Heeren J, Willnow TE, Nykjaer A. Cell Metab. 2010 Sep 8;12(3):213-23. ...Abstratct
Impact of childhood trauma on hypothalamus-pituitary-adrenal axis activity in alcohol-dependent patients. Schäfer I, Teske L, Schulze-Thüsing J, Homann K, Reimer J, Haasen C, Hissbach J, Wiedemann K. Eur Addict Res. 2010;16(2):108-14. Epub 2010 Mar 11. Abstract...
Attitudes of patients with schizophrenia and depression to psychiatric research: a study in seven European countries. Schäfer I, Burns T, Fleischhacker WW, Galderisi S, Rybakowski JK, Libiger J, Rössler W, Molodynski A, Edlinger M, Piegari G, Hrnciarova J, Gorna K, Jaeger M, Fett AK, Hissbach J, Naber D. Soc Psychiatry Psychiatr Epidemiol. 2011 Feb;46(2):159-65. Epub 2010 Feb 2.Abstract...
Childhood trauma and dissociation in patients with alcohol dependence, drug dependence, or both-A multi-center study. Schäfer I, Langeland W, Hissbach J, Luedecke C, Ohlmeier MD, Chodzinski C, Kemper U, Keiper P, Wedekind D, Havemann-Reinecke U, Teunissen S, Weirich S, Driessen M. (2010). Drug Alcohol Depend. 2010 Jun 1;109(1-3):84-9. Epub 2010 Jan 21.Abstract...
Auswahlverfahren für das Medizinstudium: Kein Ersatz für die Abiturnote W. Hampe, J. Hissbach (2010). Dtsch. Arztebl. 107(26): A-1298 free full text
A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles. Tromsdorf UI, Bruns OT, Salmen SC, Beisiegel U, Weller H. Nano Lett. 2009 Dec;9(12):4434-40.Abstract...
Role for LAMP-2 in endosomal cholesterol transport. Schneede A, Schmidt CK, Hölttä-Vuori M, Heeren J, Willenborg M, Blanz J, Domanskyy M, Breiden B, Brodesser S, Landgrebe J, Sandhoff K, Ikonen E, Saftig P, Eskelinen EL. J Cell Mol Med. 2009 Nov 19. [Epub ahead of print] Abstract...
Who will be a good physician? Admission procedures for medical and dental students. Hampe W, Hissbach J, Kadmon M, Kadmon G, Klusmann D, Scheutzel P.Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Aug;52(8):821-30.Abstract...
Motivation of young academics for medical research. Position of the German Council of Science and Humanities. Beisiegel U. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Aug;52(8):850-5.Abstract...
Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis. Broedbaek K, Poulsen HE, Weimann A, Kom GD, Schwedhelm E, Nielsen P, Böger RH. Free Radic Biol Med. 2009 Oct 15;47(8):1230-3. Epub 2009 Aug 14.Abstract...
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Linsel-Nitschke P, Heeren J, Aherrahrou Z, Bruse P, Gieger C, Illig T, Prokisch H, Heim K, Doering A, Peters A, Meitinger T, Wichmann HE, Hinney A, Reinehr T, Roth C, Ortlepp JR, Soufi M, Sattler AM, Schaefer J, Stark K, Hengstenberg C, Schaefer A, Schreiber S, Kronenberg F, Samani NJ, Schunkert H, Erdmann J. Atherosclerosis. 2009 Jul 8. [Epub ahead of print] Abstract...
Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. Bruns OT, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Lauterwasser J, Nikolic MS, Mollwitz B, Merkel M, Bigall NC, Sapra S, Reimer R, Hohenberg H, Weller H, Eychmüller A, Adam G, Beisiegel U, Heeren J. Nat Nanotechnol. 2009 Mar;4(3):193-201. Epub 2009 Jan 25. Abstract...
European Lipoprotein Club: report of the 31st ELC Annual Conference, Tutzing, 8-11 September 2008. Bernini F, Freeman D, Groen A, Heeren J, Kalopissis A, Kronenberg F, Lindstedt K, Parini P, Schuster G, Tybjaerg Hansen A, van Dij KW, von Eckardstein A. Atherosclerosis. 2009 Jul;205(1):41-7. Epub 2008 Dec 7.
Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. Laatsch A, Merkel M, Talmud P, Grewal T, Beisiegel U, Heeren J. Atherosclerosis 2009, 204: 105-11. Abstract...
Italian Society of Hematology guidelines for thalassemia and non-invasive iron measurements. Nielsen P, Engelhardt R, Grosse R, Janka G, Harmatz P, Fischer R. Haematologica. 2009 Feb;94(2):294-5; author reply 295-6. Epub 2008 Dec 23.Abstract...
Liver TAG Transiently Decreases While PL n-3 and n-6 Fatty Acids are Persistently Elevated in Insulin Resistant Mice. Scheja L, Toedter K, Mohr R, Niederfellner G, Michael MD, Meissner A, Schoettler A, Pospisil H, Beisiegel U, Heeren J. Lipids. 2008 Sep 2. [Epub ahead of print]
Acute-phase serum amyloid A as a marker of insulin resistance in mice. Scheja L, Heese B, Zitzer H, Michael MD, Siesky AM, Pospisil H, Beisiegel U, Seedorf K. Exp Diabetes Res. 2008;2008:230837. Abstract... / freefull text article.
Uptake of Colloidal Polyelectrolyte-Coated Particles and Polyelectrolyte Multilayer Capsules by Living Cells. Alumdena Munoz Javier, Oliver Kreft, Maximilian Semmling, Susanne Kempter, Andre G. Skirtach, Oliver T. Bruns, Pablo del Pino, Mathieu F. Bedard, Joachim Rädler, Josef Käs, Christian Plank, Gleb B. Sukhorukov, and Wolfgang J. Parak. Advanced Materials 10.1002/adma.200703190. Abstract...
Effects of Six APOA5 Variants, Identified in Patients With Severe Hypertriglyceridemia, on In Vitro Lipoprotein Lipase Activity and Receptor Binding. Dorfmeister B, Zeng WW, Dichlberger A, Nilsson SK, Schaap FG, Hubacek JA, Merkel M, Cooper JA, Lookene A, Putt W, Whittall R, Lee PJ, Lins L, Delsaux N, Nierman M, Kuivenhoven JA, Kastelein JJ, Vrablik M, Olivecrona G, Schneider WJ, Heeren J, Humphries SE, Talmud PJ. Arterioscler Thromb Vasc Biol. 2008 Jul 17.; [Epub ahead of print]
The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. Martin AM, Kuhlmann C, Trossbach S, Jaeger S, Waldron E, Roebroek A, Luhmann HJ, Laatsch A, Weggen S, Lessmann V, Pietrzik CU. J Biol Chem. 2008 May 2;283(18):12004-13. Abstract...
Uptake of postprandial lipoproteins into bone in vivo: Impact on osteoblast function. Niemeier A, Niedzielska D, Secer R, Schilling A, Merkel M, Enrich C, Rensen PC, Heeren J. Bone. 2008 Aug;43(2):230-7. Epub 2008 Apr 10. Abstract...
Apoprotein A-V: An important regulator of triglyceride metabolism. Kluger M, Heeren J, Merkel M. J Inherit Metab Dis. 2008 Apr 14. Abstract...
Recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells.Rellin L, Heeren J, Beisiegel U.Biochim Biophys Acta. 2008 May;1781(5):232-8. Epub 2008 Mar 5. Abstract...
European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007. Hofker M, Bernini F, von Eckardstein A, Freeman D, Heeren J, Karpe F, Kalopissis A, Kronenberg F, Kuipers F, Lindstedt K, Parini P, Schuster G, van Dijk KW. Atherosclerosis. 2008 Mar;197(1):471-9.
Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells. Prawitt J, Niemeier A, Kassem M, Beisiegel U, Heeren J. Exp Cell Res. 2008 Feb 15;314(4):814-24. Epub 2007 Nov 22. Abstract...
Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents. Tromsdorf UI, Bigall NC, Kaul MG, Bruns OT, Nikolic MS, Mollwitz B, Sperling RA, Reimer R, Hohenberg H, Parak WJ, Förster S, Beisiegel U, Adam G, Weller H. Nano Lett. 2007 Aug;7(8):2422-7. Epub 2007 Jul 20. Abstract...
Non-transferrin-bound iron in plasma following administration of oral iron drugs. Bernd Dresow, Doerte Petersen, Roland Fischer, Peter Nielsen.Biometals. 2007 Sep 13; [Epub ahead of print]
Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue. El-Armouche A, Singh J, Naito H, Wittköpper K, Didié M, Laatsch A, Zimmermann WH, Eschenhagen T. J Mol Cell Cardiol. 2007 Sep;43(3):371-6. Abstract...
Serum ferritin underestimates liver iron concentration in transfusion independent thalassemia patients as compared to regularly transfused thalassemia and sickle cell patients. Pakbaz Z, Fischer R, Fung E, Nielsen P, Harmatz P, Vichinsky E. Pediatr Blood Cancer. 2007 Sep;49(3):329-32.
Nuclear localization of enhanced green fluorescent protein homomultimers. Nicole Maria Seibel, Jihane Eljouni, Marcus Michael Nalaskowski and Wolfgang Hampe. Anal. Biochem. 2007: 368, 95-99 Abstract...
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer’s Disease. Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P. Nat Genet. 2007 Jan; 39:168-177 Abstract
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