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A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles. Tromsdorf UI, Bruns OT, Salmen SC, Beisiegel U, Weller H. Nano Lett. 2009 Dec;9(12):4434-40.Abstract...
Role for LAMP-2 in endosomal cholesterol transport. Schneede A, Schmidt CK, Hölttä-Vuori M, Heeren J, Willenborg M, Blanz J, Domanskyy M, Breiden B, Brodesser S, Landgrebe J, Sandhoff K, Ikonen E, Saftig P, Eskelinen EL. J Cell Mol Med. 2009 Nov 19. [Epub ahead of print] Abstract...
Who will be a good physician? Admission procedures for medical and dental students. Hampe W, Hissbach J, Kadmon M, Kadmon G, Klusmann D, Scheutzel P.Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Aug;52(8):821-30.Abstract...
Motivation of young academics for medical research. Position of the German Council of Science and Humanities. Beisiegel U. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2009 Aug;52(8):850-5.Abstract...
Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis. Broedbaek K, Poulsen HE, Weimann A, Kom GD, Schwedhelm E, Nielsen P, Böger RH. Free Radic Biol Med. 2009 Oct 15;47(8):1230-3. Epub 2009 Aug 14.Abstract...
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Linsel-Nitschke P, Heeren J, Aherrahrou Z, Bruse P, Gieger C, Illig T, Prokisch H, Heim K, Doering A, Peters A, Meitinger T, Wichmann HE, Hinney A, Reinehr T, Roth C, Ortlepp JR, Soufi M, Sattler AM, Schaefer J, Stark K, Hengstenberg C, Schaefer A, Schreiber S, Kronenberg F, Samani NJ, Schunkert H, Erdmann J. Atherosclerosis. 2009 Jul 8. [Epub ahead of print] Abstract...
Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. Bruns OT, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Lauterwasser J, Nikolic MS, Mollwitz B, Merkel M, Bigall NC, Sapra S, Reimer R, Hohenberg H, Weller H, Eychmüller A, Adam G, Beisiegel U, Heeren J. Nat Nanotechnol. 2009 Mar;4(3):193-201. Epub 2009 Jan 25. Abstract...
European Lipoprotein Club: report of the 31st ELC Annual Conference, Tutzing, 8-11 September 2008. Bernini F, Freeman D, Groen A, Heeren J, Kalopissis A, Kronenberg F, Lindstedt K, Parini P, Schuster G, Tybjaerg Hansen A, van Dij KW, von Eckardstein A. Atherosclerosis. 2009 Jul;205(1):41-7. Epub 2008 Dec 7.
Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. Laatsch A, Merkel M, Talmud P, Grewal T, Beisiegel U, Heeren J. Atherosclerosis 2009, 204: 105-11. Abstract...
Italian Society of Hematology guidelines for thalassemia and non-invasive iron measurements. Nielsen P, Engelhardt R, Grosse R, Janka G, Harmatz P, Fischer R. Haematologica. 2009 Feb;94(2):294-5; author reply 295-6. Epub 2008 Dec 23.Abstract...
Synthesis of bicyclic 2'-deoxynucleosides with alpha-L-ribo- and beta-D-xylo-configurations and restricted S- and N-type conformations. Shaikh KI, Kumar S, Lundhus L, Bond AD, Sharma PK, Nielsen P. J Org Chem. 2009 Feb 20;74(4):1557-66.Abstract...
Liver TAG Transiently Decreases While PL n-3 and n-6 Fatty Acids are Persistently Elevated in Insulin Resistant Mice. Scheja L, Toedter K, Mohr R, Niederfellner G, Michael MD, Meissner A, Schoettler A, Pospisil H, Beisiegel U, Heeren J. Lipids. 2008 Sep 2. [Epub ahead of print]
Acute-phase serum amyloid A as a marker of insulin resistance in mice. Scheja L, Heese B, Zitzer H, Michael MD, Siesky AM, Pospisil H, Beisiegel U, Seedorf K. Exp Diabetes Res. 2008;2008:230837. Abstract... / freefull text article.
Uptake of Colloidal Polyelectrolyte-Coated Particles and Polyelectrolyte Multilayer Capsules by Living Cells. Alumdena Munoz Javier, Oliver Kreft, Maximilian Semmling, Susanne Kempter, Andre G. Skirtach, Oliver T. Bruns, Pablo del Pino, Mathieu F. Bedard, Joachim Rädler, Josef Käs, Christian Plank, Gleb B. Sukhorukov, and Wolfgang J. Parak. Advanced Materials 10.1002/adma.200703190. Abstract...
Effects of Six APOA5 Variants, Identified in Patients With Severe Hypertriglyceridemia, on In Vitro Lipoprotein Lipase Activity and Receptor Binding. Dorfmeister B, Zeng WW, Dichlberger A, Nilsson SK, Schaap FG, Hubacek JA, Merkel M, Cooper JA, Lookene A, Putt W, Whittall R, Lee PJ, Lins L, Delsaux N, Nierman M, Kuivenhoven JA, Kastelein JJ, Vrablik M, Olivecrona G, Schneider WJ, Heeren J, Humphries SE, Talmud PJ. Arterioscler Thromb Vasc Biol. 2008 Jul 17.; [Epub ahead of print]
The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. Martin AM, Kuhlmann C, Trossbach S, Jaeger S, Waldron E, Roebroek A, Luhmann HJ, Laatsch A, Weggen S, Lessmann V, Pietrzik CU. J Biol Chem. 2008 May 2;283(18):12004-13. Abstract...
Uptake of postprandial lipoproteins into bone in vivo: Impact on osteoblast function. Niemeier A, Niedzielska D, Secer R, Schilling A, Merkel M, Enrich C, Rensen PC, Heeren J. Bone. 2008 Aug;43(2):230-7. Epub 2008 Apr 10. Abstract...
Apoprotein A-V: An important regulator of triglyceride metabolism. Kluger M, Heeren J, Merkel M. J Inherit Metab Dis. 2008 Apr 14. Abstract...
Recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells.Rellin L, Heeren J, Beisiegel U.Biochim Biophys Acta. 2008 May;1781(5):232-8. Epub 2008 Mar 5. Abstract...
European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007. Hofker M, Bernini F, von Eckardstein A, Freeman D, Heeren J, Karpe F, Kalopissis A, Kronenberg F, Kuipers F, Lindstedt K, Parini P, Schuster G, van Dijk KW. Atherosclerosis. 2008 Mar;197(1):471-9.
Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells. Prawitt J, Niemeier A, Kassem M, Beisiegel U, Heeren J. Exp Cell Res. 2008 Feb 15;314(4):814-24. Epub 2007 Nov 22. Abstract...
Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents. Tromsdorf UI, Bigall NC, Kaul MG, Bruns OT, Nikolic MS, Mollwitz B, Sperling RA, Reimer R, Hohenberg H, Parak WJ, Förster S, Beisiegel U, Adam G, Weller H. Nano Lett. 2007 Aug;7(8):2422-7. Epub 2007 Jul 20. Abstract...
Non-transferrin-bound iron in plasma following administration of oral iron drugs. Bernd Dresow, Doerte Petersen, Roland Fischer, Peter Nielsen.Biometals. 2007 Sep 13; [Epub ahead of print]
Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue. El-Armouche A, Singh J, Naito H, Wittköpper K, Didié M, Laatsch A, Zimmermann WH, Eschenhagen T. J Mol Cell Cardiol. 2007 Sep;43(3):371-6. Abstract...
Serum ferritin underestimates liver iron concentration in transfusion independent thalassemia patients as compared to regularly transfused thalassemia and sickle cell patients. Pakbaz Z, Fischer R, Fung E, Nielsen P, Harmatz P, Vichinsky E. Pediatr Blood Cancer. 2007 Sep;49(3):329-32.
Nuclear localization of enhanced green fluorescent protein homomultimers. Nicole Maria Seibel, Jihane Eljouni, Marcus Michael Nalaskowski and Wolfgang Hampe. Anal. Biochem. 2007: 368, 95-99 Abstract...
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer's Disease. Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P. Nat Genet. 2007 Jan; 39:168-177 Abstract
SorLA signaling by regulated intramembrane proteolysis. Bohm C, Seibel N, Henkel B, Steiner H, Haass C, Hampe W. J. Biol. Chem. 281, 14547-14553
Abstract
Comparative Examination of the Stability of Semiconductor Quantum Dots in Various Biochemical Buffers. Klaus Boldt, Oliver T. Bruns, Nikolai Gaponik, and Alexander Eychmüller*. J. Phys. Chem., 110 (5), 1959 -1963, 2006. Abstract / free full text article
Increased urinary excretion of 8-iso-Prostaglandin F2a in patients with HFE-related haemochromatosis. A case-control study Kom GD, Schwedhelm E, Nielsen P, Böger RH.Free Radical Biologie and Medicine 2005, in press
Give me A5 for lipoprotein hydrolysis! Merkel M, Heeren J. J Clin Invest. 2005 Oct;115(10):2694-6. Abstract / free full text article
Quantification of hormone induced atrophy of large myotubes from C2C12 and L6 cells: Atrophy-inducible and atrophy-resistant C2C12 myotubes. Sultan KR, Henkel B, Terlou M, Haagsman HP. Am J Physiol Cell Physiol. 2005 Sep 21; [Epub ahead of print] Abstract
Cultivation of three-dimensional cartilage-carrier-constructs under reduced oxygen tension. Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM, Portner R. J Biotechnol. 2005 Sep 19; [Epub ahead of print] Abstract
Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. Grewal T, Evans R, Rentero C, Tebar F, Cubells L, de Diego I, Kirchhoff MF, Hughes WE, Heeren J, Rye KA, Rinninger F, Daly RJ, Pol A, Enrich C. Oncogene. 2005 Sep 1;24(38):5809-20. Abstract
Bioavailability of oral iron drugs as judged by a 59Fe-whole-body counting technique in patients with iron deficiency anaemia. Therapeutic efficacy of iron(II)-glycine sulfate. Nielsen P, Kongi R, Buggisch P, Fischer R. Arzneimittelforschung. 2005;55(7):376-81. Abstract
Bioreactor cultivation of three-dimensional cartilage-carrier-constructs. Nagel-Heyer S, Goepfert C, Feyerabend F, Petersen JP, Adamietz P, Meenen NM, Portner R. Bioprocess Biosyst Eng. 2005 Jul;27(4):273-80. Epub 2005 Jun 1. Abstract
Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice. Ragozin S, Niemeier A, Laatsch A, Loeffler B, Merkel M, Beisiegel U, Heeren J. Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1433-8. Epub 2005 Apr 21. Abstract
Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase. Merkel M, Loeffler B, Kluger M, Fabig N, Geppert G, Pennacchio LA, Laatsch A, Heeren J. J Biol Chem. 2005 Jun 3;280(22):21553-60. Epub 2005 Mar 17. Abstract
Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation.Christen S, Finckh B, Lykkesfeldt J, Gessler P, Frese-Schaper M, Nielsen P, Schmid ER, Schmitt B. Free Radic Biol Med. 2005 May 15;38(10):1323-32. Abstract
Knockdown of Hepatic ABCA1 by RNA Interference Decreases Plasma HDL Cholesterol Levels and Influences Postprandial Lipemia in Mice. Ragozin S, Niemeier A, Laatsch A, Loeffler B, Merkel M, Beisiegel U, Heeren J. Arterioscler Thromb Vasc Biol. 2005 Apr 21; [Epub ahead of print] Abstract
HU-K4 type is a ubiquitously expressed 2 transmembrane protein associated with the endoplasmic reticulum. Munck A, Bohm C, Seibel NM, Hashemol Hosseini Z, Hampe W. FEBS J. 2005 Apr;272(7):1718-26. Abstract
Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan bound lipoprotein lipase. Merkel M, Loeffler B, Kluger M, Fabig N, Geppert G, Pennacchio LA, Laatsch A, Heeren J. J Biol Chem. 2005 Mar 17; [Epub ahead of print] Abstract
Low-dose adenoviral immunotherapy of rat hepatocellular carcinoma using single-chain interleukin-12. Waehler R, Ittrich H, Mueller L, Krupski G, Ameis D, Schnieders F. Hum Gene Ther. 2005 Mar;16(3):307-17. Abstract
Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunocytochemical analysis. Magens B, Dullmann J, Schumann K, Wulfhekel U, Nielsen P. Acta Histochem. 2005;107(1):57-65. Epub 2005 Mar 17. Abstract
Expression of different p63 variants in healing skin wounds suggests a role of p63 in reepithelialization and muscle repair. Bamberger C, Hafner A, Schmale H, Werner S. Wound Repair Regen. 2005 Jan-Feb;13(1):41-50. Abstract
Increased bone formation in mice lacking apolipoprotein E. Schilling AF, Schinke T, Munch C, Gebauer M, Niemeier A, Priemel M, Streichert T, Rueger JM, Amling M. J Bone Miner Res. 2005 Feb;20(2):274-82. Epub 2004 Nov 1. Abstract
Scavenger Receptor Class B Type I Mediates the Selective Uptake of High-Density Lipoprotein-Associated Cholesteryl Ester by the Liver in Mice. Brundert M, Ewert A, Heeren J, Behrendt B, Ramakrishnan R, Greten H, Merkel M, Rinninger F. Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):143-8. Abstract
Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone. Niemeier A, Kassem M, Toedter K, Wendt D, Ruether W, Beisiegel U, Heeren J. J Bone Miner Res. 2005 Feb;20(2):283-93. Epub 2004 Nov 1. Abstract
Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation. Heeren J, Grewal T, Laatsch A, Becker N, Rinninger F, Rye KA, Beisiegel U. J Biol Chem. 2004 Oct 12 [Epub ahead of print]. Abstract / free full text article
Cell type-specific expression of LINE-1 ORF1 and ORF2 in fetal and adult human tissues. Ergun S, Buschmann C, Heukeshoven J, Dammann K, Schnieders F, Lauke H, Chalajour F, Kilic N, Stratling WH, Schumann GG. J Biol Chem. 2004 Mar 31 [Epub ahead of print].
Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). Laatsch A, Ragozin S, Grewal T, Beisiegel U, Heeren J. Eur J Cell Biol. 2004 Apr; 83 (3): 113-20.
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double deficient fibroblasts. Eskelinen EL, Schmidt CK, Neu S, Willenborg M, Fuertes G, Salvador N, Tanaka Y, Lullmann-Rauch R, Hartmann D, Heeren J, Von Figura K, Knecht E, Saftig P. Mol Biol Cell. 2004 Apr 30.
A sensitive noninvasive method for monitoring successful liver-directed gene transfer of the low-density lipoprotein receptor in Watanabe hyperlipidemic rabbits in vivo. Tietge UJ, Cichon G, Buttner C, Genschel J, Heeren J, Gielow P, Grewe N, Dogar M, Beisiegel U, Manns MP, Lochs H, Burchert W, Schmidt HH. Gene Ther. 2004 Apr; 11 (7):574-80.
Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage. Cichon G, Willnow T, Herwig S, Uckert W, Loser P, Schmidt HH, Benhidjeb T, Schlag PM, Schnieders F, Niedzielska D, Heeren J. J Gene Med. 2004 Feb; 6 (2):166-75.
Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication. Buhmann C, Arlt S, Kontush A, Moller-Bertram T, Sperber S, Oechsner M, Stuerenburg HJ, Beisiegel U. Neurobiol Dis. 2004 Feb; 15 (1):160-70.
Mice expressing only covalent dimeric heparin binding-deficient lipoprotein lipase: muscles inefficiently secrete dimeric enzyme. Lutz EP, Kako Y, Yagyu H, Heeren J, Marks S, Wright T, Melford K, Ben-Zeev O, Radner H, Merkel M, Bensadoun A, Wong H, Goldberg IJ. J Biol Chem. 2004 Jan 2; 279 (1):238-44. Epub 2003 Oct 21.
Monitoring long-term efficacy of iron chelation therapy by deferiprone and desferrioxamine in patients with ß-thalassaemia major: application of SQUID biomagnetic liver susceptometry. Fischer R, Longo F, Nielsen P, Engelhardt R, Hider RC, Piga A. Brit J Haematol 121 :938-948 (2003).
Therapeutic dose of HIV-1 protease inhibitor saquinavir does not permanently influence early insulin signaling. Algenstaedt P, Daneshi S, Schwarzloh B, Hennigs N, Hamann A, Hansen-Algenstaedt N, Beisiegel U.. Exp Clin Endocrinol Diabetes. 2003 Dec; 111 (8):491-8.
Effective treatment of hereditary haemochromatosis with desferrioxamine in selected cases.Effective treatment of hereditary haemochromatosis with desferrioxamine in selected cases. Nielsen P, Fischer R, Buggisch P, Janka-Schaub G. Br J Haematol. 2003 Dec;123(5):952-3.
CSF-tau, CSF-Abeta1-42, ApoE-genotype and clinical parameters in the diagnosis of Alzheimer's disease: combination of CSF-tau and MMSE yields highest sensitivity and specificity. Ganzer S, Arlt S, Schoder V, Buhmann C, Mandelkow EM, Finckh U, Beisiegel U, Naber D, Muller-Thomsen T. J Neural Transm. 2003 Oct; 110 (10):1149-60.
High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras. Grewal T, de Diego I, Kirchhoff MF, Tebar F, Heeren J, Rinninger F, Enrich C. J Biol Chem. 2003 May 9; 278 (19):16478-81.
Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from scavenger reseptor class B type I (SR-BI). Brundert M, Heeren J, Greten H, Rinninger F. J Lipid Res. 2003 May; 44 (5):1020-32.
Recycling of apoprotein E is associated with cholesterol efflux and HDL internalization. Heeren J, Grewal T, Laatsch A, Rottke D, Rinninger F, Enrich C, Beisiegel U. J Biol Chem. 2003 Apr 18; 278 (16):14370-8.
Patterns of oxidized epitopes, but not NF-kappa B expression, change during atherogenesis in WHHL rabbits. Brasen JH, Hakkinen T, Malle E, Beisiegel U, Yla-Herttuala S. Atherosclerosis. 2003 Jan; 166 (1):13-21.
Fatty acids and gene expression. Beisiegel U, Heeren J., Schnieders F. Zempleni J, Daniel H., editors. Molecular Nutrition. CABI publishing, 2003: 121-134.
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