Analysis of the 4D Cine-MR Cardiac Image Data
Spatial-temporal MR image sequences of the heart contain information about shape and motion changes and pathological structures after myocardial infarction
(see Fig. 1).
Fig. 1: This figure presents five frames of a Cine-MR image sequence (a-e). Infarct area and MO can be identified in the corresponding DE-MR image (f).
In this project a software system called HeAT (Heart Analysis Tool) for quantitative analysis of 4D MR image sequences of infarct patients is presented. HeAT supports interactive segmentation of anatomical and pathological structures. Registration of Cine- and DE-MR image data is applied to enable their combined evaluation during the analysis process (see Fig. 2).
Fig. 2: Visualization of the results of direct contour overlay before (a) and after (b) rigid registration. Segmentation of the infarct area is presented in (c).
Partitioning of the myocardium in segments enables the analysis with high local resolution (see Fig. 3). Corresponding segments are generated and used for inter/intra patient comparison.
Fig. 3: Visualization of the segmented myocardial structure (a) with endocard (green) and epicard (red) and the partitioning in 100 myocardial segments of the myocardium in full (b) and detailed (c) view in Cine-MR.
Quantitative parameters were extracted and visualized (see Fig. 4). Parameters like endocard movement in the infracted area of 10 infarct patients were computed in HeAT.
Fig. 5: Representation of the quantitative parameters for all myocardial segments. The absolute values [mm] of endocardial movement (yellow circles) and the difference in wall thickness between end-diastolic and end-systolic phase (blue triangles) are displayed as well as the transmurality [%] of the infarct area (red diamonds) and the MO (green boxes).
Generally, parameters in the infarct area show the expected dysfunctional characteristics. Based on these parameters passive endocardial movement and myocardial areas with decreased contraction were identified.
Selected Publications
- Dennis Säring, Achim Barmeyer, Alexander Stork, Heinz Handels: Segmentierung des linken Ventrikels in 4D-MR-Bildfolgen unter Verwendung nicht-linearer Registrierung, 41. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik (BMT), Aachen, 2007 (eingereicht).
- Kai Müllerleile, Dennis Säring, Alexander Stork, Paul M. Bansman, Gerhard Adam, Heinz Handels, Gunnar Lund, Thomas Meinertz., Regionales Remodeling nach akutem Myokardinfarkt: Integrierte Analyse von Delayed-Enhancement- und Cine-MRT durch die HeAT-Software, 73. Jahrestagung der Deutschen Gesellschaft für Kardiologie, Clinical Research in Cardiolology, 96, Suppl. 1, 2007 (angenommen).
- Dennis Säring, Jan Ehrhardt, Alexander Stork, Paul M. Bansmann, Gunnar Lund, Heinz Handels(2006): Computer-Assisted Analysis of 4D Cardiac MR Image Sequences after Myocardial Infarction.
Methods of Information in Medicine
- Dennis Säring, Jan Ehrhardt, Alexander Stork, Paul M. Bansmann, Gunnar Lund, Heinz Handels, (2006): Analysis of the Left Ventricle after Myocardial Infarction combining 4D Cine-MR and 3D DE-MR Image Sequences.
In: Handels, H., Erhardt, J., Horsch, A., Meinzer, H.P., Tolxdorff, T. (Hrsg.), Bildverarbeitung für die Medizin 2006, Informatik aktuell, Springer Verlag, Berlin, 56-60.
- Alexander Stork, Dennis Säring, Stephanie Juchheim, Kai Müllerleile, Gunnar Lund, Paul M. Bansmann, Heinz Handels, Gerhard Adam: Heart Analysis Tool: patientenspezifische Segmentierungssoftware für integrierte Delayed-Enhancement- und Cine-MRT-Daten zur Beschreibung myokardialer Umbauprozesse nach akutem Herzinfarkt. Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren,178 Suppl (2006) 193
http://www.thieme-connect.com/ejournals/abstract/roefo/doi/10.1055/s-2006-940707
- Dennis Säring, Jan Ehrhardt, Alexander Stork, Paul M. Bansmann, Gunnar Lund, Heinz Handels: HeAT: A Software Assistant for the Analysis of LV Remodeling After Myocardial Infarction in 4D-MR Follow-Up Studies. In: Hochberger Chr., Liskowsky R. (Hrsg.), Informatik 2006, Lecture Notes in Informatics, 537-543, 2006
- Dennis Säring, Jan Ehrhardt, A. Stork, M.P. Bannsmann, G.K. Lund, Heinz Handels: HeAT -Heart Analysis Tool. 50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie, Freiburg, Tagungsband, 28-30,2005.
Project Team
Dennis SäringHeinz Handels
Cooperation Partners
Dr. Alexander Stork Dr. Paul M. Bansmann
Department of Diagnostic and Interventional Radiology, UK Hamburg-Eppendorf
Dr. Gunnar Lund
Facharzt für Innere Medizin / Kardiologie
Schwerpunkt Kardio-MRT
Roentgeninstitut Düsseldorf Dr. Kai Müllerleile
Herzzentrum, UK Hamburg-Eppendorf
