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During invasion and metastasis, cell surface glycans of tumour cells make contact with glycoreceptors (lectins) of inflammatory cells in the microenvironment. In the current project, tumour cell glycans are characterized by recombinant glycoreceptors, normally expressed in inflammatory and endothelial cells. Binding patterns of the glycan receptors will be correlated with biological properties of the tumours and prognostic parameters of the patients. The glycoproteins carrying glycoreceptor-binding glycans will be isolated and identified. In addition, glycoreceptor binding and non-binding sub-populations of tumour cells will be isolated and characterized. The project focuses on two major questions:
(i) Can new biomarkers be identified by the use of human recombinant glycoreceptors?
(ii) How do glycoreceptors of inflammatory cells in the microenvironment of tumours affect tumour progression?
Sponsor: BMBF, Reference Number 0315500B
PI: Prof. Dr. Christoph Wagener
