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| Home > Zentren > Zentrum für Diagnostik > Institut für Medizinische Mikrobiologie, Virologie und Hygiene > Arbeitsgruppe Linder

Group Linder

Our group is interested in the cytoskeleton of primary human cells, especially of monocytic and endothelial cells. We study the dynamic regulation of the actin and tubulin cytoskeletons in the context of cell adhesion, migration, invasion and phagocytosis. These cellular functions are based on closely regulated and spatially restricted reorganization of the cytoskeleton, and play critical roles during physiological or pathological processes such as diapedesis, wound healing, metastasis, or uptake of pathogens.

A detailed study of the molecular mechanisms underlying cytoskeletal dynamics is, therefore, essential for a better understanding of these processes and for the development of specific tools for their therapeutic modulation. Our projects focus on various model systems, which address different aspects of cell adhesion, migration, invasion or phagocytosis, and are all critically regulated by actin and tubulin turnover.

Funding

Current research activities are funded by the Deutsche Forschungsgemeinschaft (LI 925/3-1), the 7th European Commission framework programme Marie Curie Actions (Tissue Transmigration Training Network), and the Wilhelm Sander-Stiftung (2007.20.2).

Membership

The Invadosome Consortium is an open network of laboratories interested in cell adhesion and tissue invasion.

The Tissue Transmigration Training Network is a consortium of European labs, which is funded by the 7th Framework Program of the European Commission. The network is focused on the training of young researchers in innvovative methods and topics in invasive cell migration.

Staff

Position	Name	Phone	Fax	E-Mail
Group leader	Prof. Dr. rer. nat. S. Linder	55175	54881	s.linder@uke.de
Graduate student	M. Sc. K. el Azzouzi	55172		k.el-azzouzi@uke.de
Graduate student	M. Sc. R. Bhuwania	25451		r.bhuwania@uke.de
Graduate student	M. Sc. P. Cervero	55172		p.cervero@uke.de
Postdoc	Dr. rer. nat. M. Himmel	55863		m.himmel@uke.de
MTA	A. Mordhorst	25450		a.mordhorst@uke.de
Graduate student	M. Sc. X. Naj	25451		x.naj@uke.de
Graduate student	Dipl.-Biol. L. Panzer	55172		l.panzer@uke.de
Graduate student	Dipl.-Biol. K. Rehm	25450		k.rehm@uke.de
Graduate student	Dipl.-Biol. L. Trübe	55172		l.truebe@uke.de
Graduate student	Dipl.-Biol. C. Wiesner	25451		c.wiesner@uke.de

Projects

Detailed information on our projects can be found at the Linder Lab website.

	Macrophage adhesion and migration Influence of actin-associated proteins in the turnover of podosomal adhesions.
	Cytoskeletal cooperation at podosomes Dynamic regulation of actin-dependent podosomes by microtubules and molecular motor proteins.
	Regulation of cell invasion Intracellular trafficking of matrix metalloproteinases and their influence on extracellular matrix degradation.
	Processing of pathogens by immune cells Uptake and intracellular handling of Borrelia burgdorferi by human macrophages and dendritic cells.
	Regulation of endothelial integrity Role of RhoGTPase effectors and actin-associated proteins in the dynamic formation of cell-cell contacts.

Recent publications

Linder S, Wiesner C, Himmel M.
Degrading Devices: Invadosomes in Proteolytic Cell Invasion.
Annu Rev Cell Dev Biol. 2011 Nov 10;27:185-211. Epub 2011 Jul 21.

Cornfine S, Himmel M, Kopp P, El Azzouzi K, Wiesner C, Krüger M, Rudel T, Linder S.
The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes.
Mol Biol Cell. 2011 Jan;22(2):202-15. Epub 2010 Nov 30.

Kremerskothen J, Stölting M, Wiesner C, Korb-Pap A, van Vliet V, Linder S, Huber TB, Rottiers P, Reuzeau E, Genot E, Pavenstädt H.
Zona occludens proteins modulate podosome formation and function.
FASEB J. 2011 Feb;25(2):505-14. Epub 2010 Oct 7.

Wiesner C, Faix J, Himmel M, Bentzien F, Linder S.
KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding and extracellular matrix degradation in primary macrophages.
Blood. 2010 Sep 2;116(9):1559-69. Epub 2010 May 26.

Xavier CP, Rastetter RH, Stumpf M, Rosentreter A, Müller R, Reimann J, Cornfine S, Linder S, van Vliet V, Hofmann A, Morgan RO, Fernandez MP, Schröder R, Noegel AA, Clemen CS.
Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle.
J Mol Biol. 2009 Oct 23;393(2):287-99. Epub 2009 Aug 3.

Linder S.
Invadosomes at a glance.
J Cell Sci. 2009 Sep 1;122(Pt 17):3009-13.

Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hofmann F, Feil R.
Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells.
Mol Biol Cell. 2008 Oct;19(10):4434-41. Epub 2008 Aug 6.

Buccione R, Gimona M, Linder S (eds.).
FEBS workshop: invadopodia, podosomes and focal adhesions in tissue invasion.
Eur J Cell Biol 2008; 87 (8-9)

Reichel CA, Rehberg M, Bihari P, Moser CM, Linder S, Khandoga A, Krombach F.
Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus-specificity and a critical role in collagen IV remodeling.
J Leukoc Biol. 2008 Apr;83(4):864-74. Epub 2008 Jan 3.

Gimona M, Buccione R, Courtneidge S, Linder S.
Assembly and biological roles of podosomes and invadopodia.
Curr Opin Cell Biol. 2008 Apr;20(2):235-41. Epub 2008 Mar 11.

Thal DR, Xavier C-P, Rosentreter A, Linder S, Friedrichs B, Waha A, Pietsch T, Stumpf M, Noegel AA, Clemen CS.
Expression of coronin in diffuse gliomas is related to malignancy.
J Pathol. 2008 Mar;214(4):415-24.

Linder S.
Podosomes and invadopodia.
Scirus Topic Page 2008 (http://topics.scirus.com/)

Trasak C, Zenner G, Vogel A, Yüksekdag G, Rost R, Haase I, Fischer M, Israel L, Imhof A, Linder S, Schleicher M, Aepfelbacher M.
Yersinia protein kinase YopO is activated by a novel G-actin binding process.
J Biol Chem. 2007 Jan 26;282(4):2268-77. Epub 2006 Nov 22.

Chellaiah MA, Kuppuswamy D, Lasky L, Linder S.
Role of Src kinase and PTP-PEST in the regulation of phosphorylation of WASP and resulting osteoclast bone resorption.
J Biol Chem. 2007 Mar 30;282(13):10104-16. Epub 2007 Feb 5.

Linder S.
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation.
Trends Cell Biol. 2007 Mar;17(3):107-17. Epub 2007 Feb 1.