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1 Originalarbeiten
Thies A, Mangold U, Moll I, Schumacher U (2001) PAS-positive loops and networks as a prognostic indicator in cutaneous malignant melanoma. J Pathol 195: 537-542.
Thies A, Pfuller U, Schachner M, Horny HP, Molls I, Schumacher U (2001) Binding of mistletoe lectins to cutaneous malignant melanoma: implications for prognosis and therapy. Anticancer Res 21: 2883-2887.
Thies A, Moll I, Berger J, Schumacher U (2001) Lectin binding to cutaneous malignant melanoma: HPA is associated with metastasis formation. Br J Cancer 84:819-823.
Thies A, Schachner M, Moll I, Berger J, Schulze HJ, Brunner G, Schumacher U (2002) Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. Eur J Cancer 38: 1708-1716.
Thies A, Moll I, Berger J, Wagener C, Brummer J, Schulze HJ, Brunner G, Schumacher U (2002) CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease. J Clin Oncol 20: 2530-2536.
Thies A, Schachner M, Berger J, Moll I, Schulze HJ, Brunner G, Schumacher U (2004) The developmentally regulated neural crest-associated glycotope HNK-1 predicts metastasis in cutaneous malignant melanoma. J Pathol 203: 933-939.
Thies A, Nugel D, Pfuller U, Moll I, Schumacher U (2005) Influence of mistletoe lectins and cytokines induced by them on cell proliferation of human melanoma cells in vitro. Toxicology 207: 105-116.
Freudlsperger C, Moll I, Schumacher U, Thies A (2006) Anti-proliferative effect of peroxisome proliferator-activated receptor gamma agonists on human malignant melanoma cells in vitro. Anticancer Drugs 17: 325-332.
Freudlsperger C, Thies A, Pfuller U, Schumacher U (2007) The proteasome inhibitor bortezomib augments anti-proliferative effects of mistletoe lectin-I and the PPAR-gamma agonist rosiglitazone in human melanoma cells. Anticancer Res 27: 207-213.
Thies A, Mauer S, Fodstad O, Schumacher U (2007) Clinically proven markers of metastasis predict metastatic spread of human melanoma cells engrafted in scid mice. Br J Cancer 96: 609-616.
Thies A, Berlin A, Brunner G, Schulze HJ, Moll I, Pfuller U, Wagener C, Schachner M, Altevogt P, Schumacher U (2007) Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases. Cancer Lett 248: 68-80.
Thies A, Dautel P, Meyer A, Pfüller U, Schumacher U (2008) Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model. Br J Cancer 98: 106-112. Epub 2007 Nov 20.
Thies A, Peldschus K, Ittrich H, Adam G, Altevogt P, Wagener C, Schumacher U (2009) Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model. Cancer Lett 274: 194-200. Epub 2008 Oct 14.
Freudlsperger C, Dahl A, Hoffmann J, Reinert S, Schumacher U (2010) Mistletoe lectin-I augments antiproliferative effects of the PPAR# agonist rosiglitazone on human malignant melanoma cells. Phytother Res, Published online. DOI: 10.1002/ptr.3122.
Hadshiew IM, Barre K, Dahl A, Moll I. Telomere-homologue oligonucleotides (T-oligos), all-trans retinoic acid (ATRA) and 1, 25 dihydroxy-Vitamin D3 (VitD3) induce apoptosis and cell- cycle arrest in human melanoma cells. J Invest Dermatol, submitted.
Dahl A, Teegen J, Altevogt P, Löning T, Schumacher U. Glycoconjugate expression in adenoid cystic carcinoma of the salivary glands: upregulation of L1 predicts fatal prognosis. Histopathology, accepted with minor revisions.
2 Publizierte Kongressbeiträge
Thies A, Moll I, Pfüller U, Schumacher U (2001) Lectins as prognostic markers in cutaneous malignant melanoma. 10. Treffen der Ostseeanatomen, Kiel, Ann Anat 183:188.
Thies A, Moll I, Pfüller U, Berger J, Schumacher U (2002) Expression of HPA-binding glycoconjugates is an independent marker for metastasis in primary malignant melanoma. 96. Versammlung der Anatomischen Gesellschaft, Münster, Ann Anat 200:16.
Schumacher U, Mauer S, Moll I, Schachner M, Wagener C, Fodstad O, Thies A (2003) Growth, metastatic spread and marker expression of human cutaneous malignant melanoma cells grown in scid mice. 98. Versammlung der Anatomischen Gesellschaft, Dresden, Ann Anat 185:148.
Thies A, Nugel D, Meyer A, Pfüllere U, Schumacher U (2003) Targeting metastatic cells with ribosome inactivating protein mistletoe lectin I. 98. Versammlung der Anatomischen Gesellschaft, Dresden, Ann Anat 185:149.
Hadshiew IM, Barre K, Thies A, Moll I (2003) Telomer-homologe Oligonucleotide (T-oligos), induzieren Apoptose stärker als All-Trans-Retinsäure (ATRA) und 1,25 Di-Hydroxy-Vitamin D3 (VitD3) in Jurkat und Melanom P1/28, JDDG (1), Suppl 1, 2003.
Hadshiew IM, Barre K, Thies A, Moll I (2003) Induction of apoptosis in melanoma cells by telomere-homologue oligos, retinoic acid and 1,25 (OH)2 Vitamine D3. JEADV, Vol. 17. Suppl 3, FC9-2.
Hadshiew IM, Barre K, Thies A, Moll I (2004) Telomere-homologue oligonucleotides induce apoptosis in human melanoma cells; co-treatment with all-trans retinoic acid or 1,25-dihydroxy-vitamin D3 potentiates this effect. J Invest Dermatol 122: 928.
Hadshiew IM, Barre K, Thies A, Moll I (2004) From melanogenesis to melanoma: Modulation by telomere homologous oligonucleotides (T-oligos). J Invest Dermatol 123: 286.
Freudlsperger C, Thies A, Schumacher U (2005) Peroxisome proliferator activated receptor # agonists ("glitazones") inhibit growth of human malignant melanoma cells in vitro. 100. Versammlung der Anatomischen Gesellschaft Leipzig, Germany; Ann Anat 187: 38.
Thies A, Meyer A, Dautel P, Hirche A, Nugel D, Pfüller U, Schumacher U (2005) Mistletoe lectin I as a new tool in melanoma therapy? In vitro and in vivo studies on a controversial topic. 100. Versammlung der Anatomischen Gesellschaft Leipzig, Germany; Ann Anat 187: 69.
Dahl A, Teegen J, Altevogt P, Löning T, Schumacher U (2010) Glycoconjugate expression in adenoid cystic carcinoma of the salivary glands: L1 upregulation is associated with poor prognosis, DKK Berlin; Onkologie 2010 in press.
3 Vorträge und Poster
Thies A, Moll I, Pfüller U, Schumacher U (2000) Carbohydrate residues as prognostic markers in cutaneous malignant melanoma. 20th International Carbohydrate Symposium - ICS Hamburg, 27. 08. - 01.09. 2000.
Thies A, Moll I, Schumacher U (2000) HPA, but not PHA-L, SNA-I, WGA or MAA, is a prognostic marker in cutaneous malignant melanoma. 30th Annual Meeting of the ESDR, Berlin, 21. - 23. 09. 2000.
Thies A, Moll I, Schachner M, Berger J, Schumacher U (2001) Neoexpression of the neural cell adhesion molecule L1 in malignant melanoma is strongly associated with metastatic spread. Kongress der Arbeitsgemeinschaft Deutsche Krebsforschung (AEK), Heidelberg, 02. - 06. 04. 2001.
Thies A (2002) Glykostrukturen als prognostische Marker beim kutanen malignen Melanom. Treffen der Norddeutschen Pathologen, Hamburg, 17. 01. 2002.
Thies A, Moll I, Schulze HJ, Schumacher U (2002) Glykostrukturen im kutanen malignen Melanom: Hohe prognostische Wertigkeit. 10. Jahrestagung der Arbeitsgemeinschaft Dermatologische Histologie (ADH), Münster, 12. - 14. 02. 2002.
Thies A, Moll I, Schumacher U (2002) Neue prognostische Marker beim kutanen malignen Melanom: Glykostrukturen zeigen hohe prognostische Relevanz und haben vermutlich funktionelle Bedeutung bei der Metastasierung. 11. Hansisches Dermatologentreffen, Lübeck, 21. - 22. 06. 2002.
Thies A, Nugel D, Meyer A, Valentiner U, Pfüller U, Schumacher U, Moll I (2002) Can mistletoe lectins help melanoma patients? In vitro and in vivo studies on a controversal topic. 5th Teupitzer Colloquium. Apoptosis as a Therapeutic Target in Dermatology. Teupitz Juli, 2002.
Schumacher U, Mewe M, Thies A, Schneppenheim R, Pfüller U, Tielker D, Jäger KE (2004) Magic bullets and lectins reunited-Ehrlich`s contribution to lectinology. World Conference on Magic Bullets, Nürnberg, Sept 9-11, 2004.
Schumacher U, Mauer S, Moll I, Schachner M, Wagener C, Fodstad O, Thies A (2006) Growth, metastatic spread and marker expression of human cutaneous malignant melanoma cells grown in scid mice. RAF-USAF, Dresden, 2006.
Freudlsperger C, Thies A, Schumacher U (2005) The influence of proteasome inhibitor bortezomib (Velcade®) on intracytoplasmic proteins acting as anti-proliferative proteins on malignant melanoma. 22. Arbeitstagung der Anatomischen Gesellschaft in Würzburg, 2005.
Thies A, Meyer A, Dautel P, Hirche A, Nugel D, Pfüller U, Schumacher U (2005) Purified mistletoe lectin I as a new tool in melanoma therapy? In vitro and in vivo studies on a controversial topic. 100. Versammlung der Anatomischen Gesellschaft Leipzig, 2005.
Stübke K, Augustin C, Püschel K, Schumacher U, Thies A (2006) Quantitative determination of human tumour load in murine lungs withe real-time PCR using amelogenin primers.
85. Jahrestagung der Deutschen Gesellschaft für Rechtsmedizin und DNA in Forensics 2006, Innsbruck, Österreich.
Freudlsperger C, Schumacher U, Pfüller U, Thies A (2006) The Influence of a combination of mistletoe lectin I and the PPAR# agonist rosiglitazone on the proliferation of human malignant melanoma cells in vitro. Jahrestagung der Anatomischen Gesellschaft, Freiburg, 2006.
Thies A, Berlin A, Brunner G, Schulze HJ, Schumacher U (2006) Glycoconjugate profiling of matched primary melanoma, sentinel node and distant metastases: implications for diagnosis prognosis and therapy, Jahrestagung der Anatomischen Gesellschaft, Freiburg, 2006.
Thies A, Schachner M, Wagener C, Moll I, Pfüller U, Schulz HJ, Brunner G, Altevogt P, Schumacher U (2007) Glycoconjugates as markers of metastasis in cutaneous malignant melanoma, Forschungstag UKE 2007, Hamburg.
Stübke K, Augustin C, Püschel K, Schumacher U, Thies A (2007) Quantification of tumour cell load in lung tissue sections of a human melanoma xenograft scid mouse model using Real-time PCR. 24. Arbeitstagung der Anatomischen Gesellschaft in Würzburg, Sept. 2007.
Teegen J, Fehlauer F, Altevogt P, Löning T, Schumacher U, Thies A (2007) Glycoconjugate expression as prognostic indicator in adenoid cystic carcinoma of the salivary glands. 24. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, Sept. 2007.
Thies A, Peldschus K, Adam G, Ittrich H, Schumacher U (2007) Magnetic resonance imaging of distant metastases in a clinically relevant human melanoma cell xenograft scid mouse model. 24. Arbeitstagung der Anatomischen Gesellschaft, Würzburg Sept. 2007.
Dahl A, Heine M, Horling K, Müller I, Kesel N, Nehmann N, Schmid K, Schröder C, Stübke K, Ullrich S, Valentiner U, Schumacher U (2009) Glucoconjugates as target structures for the defence against the enemy: Clinically relevant animal models. Forschungstag UKE 2009, Hamburg.
Dahl A, Meyer A, Dautel P, Nugel D, Pfüller U, Dander F, Ehm A, Nehmann N, Krieger-Hinck N, Schumacher U (2010) Effects of purified mistletoe lectin I (ML-I) compared with aqueous mistletoe extracts on melanoma growth and metastasis in a scid mouse model. 105. Versammlung der Anatomischen Gesellschaft, März 2010, Hamburg.
