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The scientific topics of the consortium are all centred on the concept of adaptation. In the nervous system this concept comprises plasticity as (i) the reaction of the organism to the loss of a peripheral sense (e.g. blindness) or a brain lesion (e.g. stroke), but also in neurodegeneration (e.g. AD) or (ii) to a new demand (e.g. structural changes after acquiring a new skill). During development the organism is shaped to cope with the existing environment. Learning is the property of the organism to adapt to changes in the environment. Finally we will investigate the state of the organism when adaptation is compromised as in aging, microvascular disease and neurodegeneration (e.g. AD).
Physiological plasticity
• Microscale i.e. synaptic plasticity (Kneussel, Kuhl)
• Mesoscale i.e. circuits (Engel, Hanganu-Opatz, Isbrandt, Kral)
• Macroscale i.e. human imaging (Büchel, Gerloff, May, Röder)
Lesion induced plasticity
• Stroke (Gerloff, Glatzel, Knecht)
• Sensory deprivation (Büchel, Kral, Röder)
Learning and memory
• Microscale i.e. synaptic plasticity (Kneussel, Kuhl)
• Macroscale i.e. human imaging, robotics (Büchel, Engel, Kalisch, May, Röder, Zhang)
Development
• Animal models (Hanganu-Opatz, Isbrandt, Kral)
• Human models (Kral, Kutsche, Röder)
Neurodegeneration
• Microscale i.e. aggregated proteins (Glatzel, Mandelkow)
• Macroscale i.e. structural neuroimaging (Büchel, May)
