Max-Planck-Unit for Structural Molecular Biology
c/o DESY, Notkestr. 85
22607 Hamburg
Tel: +49-40-8998-2810
Fax: +49-40-8971-6822
Email: mand@mpasmb.desy.de
 

July 5, 1943
 

1964 – 1969

1970 – 1973

1974 – 1976

1976 – 1985

since 1986

study of physics (Braunschweig, New Orleans, Hamburg)

doctoral thesis in biophysics, MPI for Medical Research, Heidelberg

postdoc, Brandeis University, Boston, USA

group leader, MPI for Medical Research, Heidelberg

director, Max-Planck-Unit for Structural Molecular Biology, Hamburg
 

Since 1999 8 PhD-students and 2 MD students
 

Scientific member of Max-Planck-Society

Member of various German and international societies in biochemistry, biophysics, cell biology, neuroscience
 

 
Structural biology;

Cytoskeleton (structure and function);

Tau protein in Alzheimer disease;
 

• Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E.-M., Mandelkow, E. (1997). MARK - a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89: 297-308

• Kozielski F, Sack S, Marx A, Thormählen M, Schönbrunn E, Biou V, Thompson A, Mandelkow E-M, Mandelkow E (1997) The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell 91: 985-994

• Hoenger A, Sack S, Thormählen M, Marx A, Müller J, Gross H, Mandelkow E (1998) Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: Comparison with X-ray structure and implications for motility. J. Cell Biol. 141: 419-430

• von Bergen M, Friedhoff P, Biernat J, Heberle J, Mandelkow E-M, Mandelkow E (2000) Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif (306-VQIVYK-311) forming beta structure. Proc. Natl. Acad. Sci. USA 97: 5129-5134

• Mandelkow E-M, Thies E, Trinczek B, Biernat B, Mandelkow E (2004) MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J. Cell Biol. 167: 99-110

• Pickhardt M, Gazova Z, von Bergen M, Khlistounova I, Wang Y-P, Hascher A, Mandelkow E-M, Biernat J, Mandelkow E (2005) Anthraquinones inhibit tau aggregation and dissolve Alzheimer paired helical filaments in vitro and in cells. J. Biol. Chem. 280: 3628-3635

• Goldsbury, C., Mocanu, M., Thies, E., Kaether, C., Haass, C., Keller, P., Biernat, J., Mandelkow, E.-M., Mandelkow, E. (2006). Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta. Traffic 7, 873-888.

• Konzack, S., Thies, E., Marx, A., Mandelkow, E.-M., Mandelkow, E. (2007). Swimming against the tide: Mobility of the microtubule-associated protein Tau in neurons. J. Neurosci., 27, 9916-9927.

• Mocanu, M., Nissen, A. Eckermann, K., Khlistunova, I., Biernat, J, Drexler, D., Petrova, O., Schönig, K., Bujard, H., Mandelkow, E., Zhou, L., Rune, G., Mandelkow, E.M. (2008). The potential for beta structure in the repeat domain of Tau protein determines aggregation, synaptic decay, neuronal loss, and co-assembly with endogenous Tau in inducible mouse models of tauopathy. J. Neurosci. 28, 737-748.

• Bulic, B., Pickhardt, M., Schmidt, B., Mandelkow, E.-M., Waldmann, H., Mandelkow, E. (2009). Development of Tau aggregation inhibitors for Alzheimer disease. Angew. Chemie Int. Ed. 48, 2-15.