Institut für Zelluläre und Molekulare Kognition
Zentrum für Molekulare Neurobiologie
Universitätsklinikum Hamburg-Eppendorf
Martinistr. 52
20246 Hamburg
Tel: +49-40-7410-56277
Fax: +49-40-7410-562xx
Email: kuhl@zmnh.uni-hamburg.de
 

February 1, 1958
 

1977-1983

1984-1988

 
1989-1991

 
1991-1993

 
1994-2002

 
2002-2008

 
2005-2008

2005-2008

 
2006-2008

2007-2008

 
Since 2008

 
Since 2008

Studies of Biology at the J.-W.-Goethe University, Frankfurt

Ph.D. thesis at the Institute for Molecular Biology, University of Zurich, Zurich (Switzerland) with Prof. Dr. C. Weissmann

EMBO Long-term fellow at the College of Physicians and Surgeons, Columbia University, New York (USA) with Prof. Dr. E. Kandel

Research Associate at the Howard Hughes Medical Institute, Columbia University, New York (USA) with Prof. Dr. Eric Kandel

Research group leader at the Center of Molecular Neurobiology (ZMNH), University of Hamburg, Hamburg (Germany)

Full Professor of Molecular Neurobiology and Animal Biochemistry, Faculty of Biology, Chemistry and Pharmacy, FU-Berlin

Member of the Medical Faculty of the Charité University Medicine Berlin

Speaker of the DFG Research Training Program GRK1123, Learning and Memory Consolidation in the Hippocampal Formation

Faculty of the Graduate School ‘Mind and Brain’ (HU-Berlin)

Founding Director of the cluster of excellence ‘Neurocure’ (FUBerlin/HU-Berlin/Charité)

Full Professor of Neuroscience, Director of the Institute for Cellular and Molecular Cognition, University of Hamburg

Director of the Center for Molecular Neurobiology Hamburg (ZMNH)
 

Since 1997 8 PhD-students and 6 MD-students
 

Review editor of Frontiers in Molecular Neuroscience

Member of the Society for Neuroscience

Member of the Molecular and Cellular Cognition Society
 

Mammalian brain neuroplasticity, learning and memory

Regulation of synaptic activity-dependent gene expression

mRNA transport and local translation in dendrites contributing to plasticity and
memory
 

• Qian Z, Gilbert ME, Colicos MA, Kandel ER, Kuhl D (1993) Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature 361:453-457.

• Link W, Konietzko U, Kauselmann G, Krug M, Schwanke B, Frey U, Kuhl D (1995) Somatodendritic expression of an immediate early gene is regulated by synaptic activity. PNAS 92:5734-5738.

• Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D (1999) The polo-like protein kinases Fnk and Snk associate with a Ca2+- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J 18:5528-5539.

• Konietzko U, Kauselmann G, Scafidi J, Staubli U, Mikkers H, Berns A, Schweizer M, Waltereit R, Kuhl D (1999) Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP. EMBO J 18:3359-3369.

• Waltereit R, Dammermann B, Wulff P, Scafidi J, Staubli U, Kauselmann G, Bundman M, Kuhl D (2001) Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation. J Neurosci 21:5484-5493.

• Wulff P, Vallon V, Huang DY, Volkl H, Yu F, Richter K, Jansen M, Schlunz M, Klingel K, Loffing J, Kauselmann G, Bosl MR, Lang F, Kuhl D (2002) Impaired renal Na+ retention in the sgk1-knockout mouse. J Clin Invest 110:1263-1268.

• Chowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF (2006) Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52:445-459.

• Shepherd JD, Rumbaugh G, Wu J, Chowdhury S, Plath N, Kuhl D, Huganir RL, Worley PF (2006) Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron 52:475-484.

• Plath N*, Ohana O*, Dammermann B, Errington ML, Schmitz D, Gross C, Mao XS, Engelsberg A, Mahlke C, Weizl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Boesl MR, Lipp HP, Grant SGN, Bliss TVP, Wolfer DP, Kuhl D (2006) Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron 52:437-444. *The first two authors contributed to an equal extent.

• Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF (2008) Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59:70-83.