Universitätsklinikum Hamburg-Eppendorf
DFG Heisenberg Team Experimentelle Neuropädiatrie
Klinik für Geburtshilfe, Kinder- & Jugendmedizin
Zentrum für Molekulare Neurobiologie Hamburg
Martinistrasse 52
20246 Hamburg
Tel.: +49-40-7410-56650
Fax: +49-40-7410-56263
Email: isbrandt@uke.de
 

October 03, 1967
 

1989-1996    

1990-1996

 
1997

1996-1997

 
1998

1996-1998

 
1998-2008

 
 
2005-2006

 
since 2009

Study of Medicine, University Hospital Göttingen, Göttingen

Experimental work for doctoral thesis and follow-up studies in the group of Prof. K. von Figura, University of Göttingen

M.D. Thesis defense, University of Göttingen

Children’s Hospital of the University Medical Center Hamburg-Eppendorf, Germany, Arzt im Praktikum (pre-registration house officer)

Full license to Practice Medicine

Research group leader at the Children’s Hospital of the University
Hospital Hamburg-Eppendorf

Head of a research group at the Institute for Neural Signal Transduction of the Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Germany

Visiting scientist in the laboratory of Prof. G. Buzsáki, Center for Molecular and Behavioral Neuroscience, Rutgers University Newark, NJ, USA

DFG Heisenberg Professor for Experimental Neuropediatrics at the Center for Obstetrics and Pediatrics and the Center for Molecular Neurobiology, UKE
 

Since 1999 5 PhD-students, 3 diploma students and 5 MD students
 

Member of the Society for Neuroscience (SFN)

Member of the German Society for Neuroscience

Member of the German Physiological Society
 

The contribution of intrinsic neuronal properties to cortical and hippocampal network activities and their involvement in learning and memory processes

Pathophysiology of channelopathies

Brain energy metabolism
 

• Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bahring R, Priori S, Guicheney P, Monnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D. (2006) C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Hum Mol Genet 15: 2888-2902

• Callsen B, Isbrandt D, Sauter K, Hartmann LS, Pongs O, Bahring R. (2005) Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected]. J Physiol 568: 397-412

• Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D. (2005) Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci 8: 51-60

• ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, Isbrandt D, Wallis J, Neubauer S. (2005) Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation 111: 2477-2485

• Schmidt A, Marescau B, Boehm EA, Renema WK, Peco R, Das A, Steinfeld R, Chan S, Wallis J, Davidoff M, Ullrich K, Waldschutz R, Heerschap A, De Deyn PP, Neubauer S, Isbrandt D. (2004) Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. Hum Mol Genet 13: 905-921

• Steinfeld R, Steinke HB, Isbrandt D, Kohlschütter A, Gartner J. (2004) Mutations in classical late infantile neuronal ceroid lipofuscinosis disrupt transport of tripeptidyl-peptidase I to lysosomes. Hum Mol Genet 13: 2483-2491

• Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D. (2003) Pacemaker channel dysfunction in a patient with sinus node disease. J Clinical Investigation 111: 1537-1545

• Michel U, Kallmann B, Rieckmann P, Isbrandt D. (2002) UM 9(5)h and UM 9(5)p, human and porcine noncoding transcripts with preferential expression in the cerebellum. RNA 8: 1538-1547

• Neu A, Neuhoff H, Trube G, Fehr S, Ullrich K, Roeper J, Isbrandt D. (2002) Activation of GABA_A receptors by guanidinoacetate: a novel pathophysiological mechanism. Neurobiol Dis 11: 298-307

• Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D. (2001) Conserved Kv4 N-terminal domain critical for effects of kv channel- interacting protein 2.2 on channel expression and gating. J Biol Chem 276: 23888-23894.